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BACKGROUND: IGTS is a rare phenomenon of paradoxical germ cell tumor (GCT) growth during or following treatment despite normalization of tumor markers. We sought to evaluate the frequency, clinical characteristics and outcome of IGTS in patients in 21 North-American and Australian institutions. METHODS: Patients with IGTS diagnosed from 2000-2017 were retrospectively evaluated. RESULTS: Out of 739 GCT diagnoses, IGTS was identified in 33 patients (4.5%). IGTS occurred in 9/191 (4.7%) mixed-malignant GCTs, 4/22 (18.2%) immature teratomas (ITs), 3/472 (0.6%) germinomas/germinomas with mature teratoma, and in 17 secreting non-biopsied tumours. Median age at GCT diagnosis was 10.9 years (range 1.8-19.4). Male gender (84%) and pineal location (88%) predominated. Of 27 patients with elevated markers, median serum AFP and Beta-HCG were 70 ng/mL (range 9.2-932) and 44 IU/L (range 4.2-493), respectively. IGTS occurred at a median time of 2 months (range 0.5-32) from diagnosis, during chemotherapy in 85%, radiation in 3%, and after treatment completion in 12%. Surgical resection was attempted in all, leading to gross total resection in 76%. Most patients (79%) resumed GCT chemotherapy/radiation after surgery. At a median follow-up of 5.3 years (range 0.3-12), all but 2 patients are alive (1 succumbed to progressive disease, 1 to malignant transformation of GCT). CONCLUSION: IGTS occurred in less than 5% of patients with GCT and most commonly after initiation of chemotherapy. IGTS was more common in patients with IT-only on biopsy than with mixed-malignant GCT. Surgical resection is a principal treatment modality. Survival outcomes for patients who developed IGTS are favourable.
In the spring of 1267 Abbot Philip of Clairvaux, visiting the Cistercian abbey of Herkenrode in the diocese of Liège, was informed of the exceptionally holy conduct of a woman living a few miles away, in the village of Spalbeek. Philip went to see her and was greatly impressed, for, as he wrote upon his return to Clairvaux,
The combination of strong gravitational lensing and stellar kinematics provides a powerful and robust method to investigate the mass and dynamical structure of early-type galaxies. We demonstrate this approach by analysing two massive ellipticals from the XLENS Survey for which both high-resolution HST imaging and X-Shooter spectroscopic observations are available. We adopt a flexible axisymmetric two-component mass model for the lens galaxies, consisting of a generalised NFW dark halo and a realistic self-gravitating stellar mass distribution. For both systems, we put constraints on the dark halo inner structure and flattening, and we find that they are dominated by the luminous component within one effective radius. By comparing the tight inferences on the stellar mass from the combined lensing and dynamics analysis with the values obtained from stellar population studies, we conclude that both galaxies are characterised by a Salpeter-like stellar initial mass function.
We present first results from the Intermediate Redshift OSIRIS Chemo-Kinematic Survey (IROCKS) of z ∼ 1 star forming galaxies (Mieda et al. in prep). We have targeted Hα and [NII] emission lines in J-band and have spatially resolved the galaxies at sub-kilo parsec scale. We have combined our sample with deep HST continuum images, and are able to reveal the dynamics, morphologies, metallicity distribution, emission-line diagnostics, and star formation rates of galaxies spanning this crucial z ∼ 1 epoch.
We present the KMOS (K-band Multi-Object Spectrograph) Cluster and VIRIAL (VLT IRIFU Absorption Line) Guaranteed Time Observation (GTO) programs. KMOS provides 24 arms each feeding an integral field unit (14×14 spaxels of 0.2″ pixels) for IZ, YJ, H and K band near infrared (NIR) medium resolution spectroscopy (R ∼ 3500). Targets are selected from a 7.2′ diameter patrol field. Ultra-deep spectroscopy of ∼ 80 early-type cluster galaxies (∼ 20hr on source) and ∼ 200 (∼ 10hr on source) early-type field galaxies at 1 < z < 2 will dramatically improve the situation at z > 1 for which measurements of stellar velocity dispersions and absorption indices are limited to a few, often relatively young passively evolving galaxies (e.g. Bezanson 2013). In ESO Periods P92 and P93, 15 nights worth of data has been collected for KMOS-Clusters and 6 nights for VIRIAL: this will be supplemented with more data in upcoming semesters. All galaxies have multiband HST imaging including existing or upcoming WFC3 IR imaging, providing stellar mass maps and sizes. Combined with our dispersion measurements, this will allow us to examine the fundamental plane and the dynamical mass of a large sample of z > 1 galaxies for the first time, for both cluster and field galaxies.
Observations and simulations indicate that bars are important agents to transfer material towards galaxy centers. However, observational studies devoted to investigate the effects of bars in galaxy centers are not yet conclusive. We have used a sample (Coelho & Gadotti 2011) of nearby face–on galaxies with available spectra (SDSS database) to investigate the footprints of bars in galaxy centers by analysing the central ionized gas properties of barred and unbarred galaxies separately. We find statistically significant differences in the Hβ Balmer extinction, star formation rate per unit area, in the [S ii]λ6717/[S ii]λ6731 line ratio, and notably in the N2 parameter (N2 = log([N ii]λ6583/Hα)). A deeper analysis reflects that these differences are only relevant for the less massive bulges (≲1010M⊙). These results have important consequences for studies on bulge formation and galaxy evolution.
Methods to recover the fossil record of galaxy evolution encoded in their optical spectra have been instrumental in processing the avalanche of data from mega-surveys along the last decade, effectively transforming observed spectra onto a long and rich list of physical properties: from stellar masses and mean ages to full star formation histories. This promoted progress in our understanding of galaxies as a whole. Yet, the lack of spatial resolution introduces undesirable aperture effects, and hampers advances on the internal physics of galaxies. This is now changing with 3D surveys. The mapping of stellar populations in data-cubes allows us to figure what comes from where, unscrambling information previously available only in integrated form. This contribution uses our starlight-based analysis of 300 CALIFA galaxies to illustrate the power of spectral synthesis applied to data-cubes. The selected results highlighted here include: (a) The evolution of the mass-metallicity and mass-density-metallicity relations, as traced by the mean stellar metallicity. (b) A comparison of star formation rates obtained from Hα to those derived from full spectral fits. (c) The relation between star formation rate and dust optical depth within galaxies, which turns out to mimic the Schmidt-Kennicutt law. (d) PCA tomography experiments.
We resolve spatially the star formation history of 300 nearby galaxies from the CALIFA integral field survey to investigate: a) the radial structure and gradients of the present stellar populations properties as a function of the Hubble type; and b) the role that plays the galaxy stellar mass and stellar mass surface density in governing the star formation history and metallicity enrichment of spheroids and the disks of galaxies. We apply the fossil record method based on spectral synthesis techniques to recover spatially and temporally resolved maps of stellar population properties of spheroids and spirals with galaxy mass from 109 to 7×1011 M⊙. The individual radial profiles of the stellar mass surface density (μ⋆), stellar extinction (AV), luminosity weighted ages (〈logage〉L), and mass weighted metallicity (〈log Z/Z⊙〉M) are stacked in seven bins of galaxy morphology (E, S0, Sa, Sb, Sbc, Sc and Sd). All these properties show negative gradients as a sight of the inside-out growth of massive galaxies. However, the gradients depend on the Hubble type in different ways. For the same galaxy mass, E and S0 galaxies show the largest inner gradients in μ⋆; and Andromeda-like galaxies (Sb with log M⋆ (M⊙) ∼ 11) show the largest inner age and metallicity gradients. In average, spiral galaxies have a stellar metallicity gradient ∼ −0.1 dex per half-light radius, in agreement with the value estimated for the ionized gas oxygen abundance gradient by CALIFA. A global (M⋆-driven) and local (μ⋆-driven) stellar metallicity relation are derived. We find that in disks, the stellar mass surface density regulates the stellar metallicity; in spheroids, the galaxy stellar mass dominates the physics of star formation and chemical enrichment.
We present stellar mass maps for the S4G sample based on imaging at 3.6 μm that we correct for the presence of non-stellar emission using an ICA technique. Our dust-free images can be readily converted into stellar mass maps, and this important legacy dataset will be made public through IRSA.
Two new integral field units (IFUs) were installed recently on the WIYN Observatory's 3.5-meter telescope at Kitt Peak. These unique IFUs contain fibers of different sizes in the same head. This design allows smaller fibers to sample regions of higher surface brightness, providing higher spatial resolution while maintaining adequate signal-to-noise (S/N). Conversely, larger fibers maintain S/N at the expense of spatial resolution in the lower surface brightness regions of galaxies. The new IFUs were built with funds from NSF award ATI-0804576.
Context: we present a study of the central 200 pc of NGC 6951, in the optical and NIR, taken with the Gemini North Telescope integral field spectrographs, with resolution of ~ 0”.1 Methods: we used a set of image processing techniques, as the filtering of high spatial and spectral frequencies, Richardson-Lucy deconvolution and PCA Tomography (Steiner et al.2009) to map the distribution and kinematics of the emission lines. Results: we found a thick molecular disk, with the ionization cone highly misaligned.