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To develop a pediatric research agenda focused on pediatric healthcare-associated infections and antimicrobial stewardship topics that will yield the highest impact on child health.
The study included 26 geographically diverse adult and pediatric infectious diseases clinicians with expertise in healthcare-associated infection prevention and/or antimicrobial stewardship (topic identification and ranking of priorities), as well as members of the Division of Healthcare Quality and Promotion at the Centers for Disease Control and Prevention (topic identification).
Using a modified Delphi approach, expert recommendations were generated through an iterative process for identifying pediatric research priorities in healthcare associated infection prevention and antimicrobial stewardship. The multistep, 7-month process included a literature review, interactive teleconferences, web-based surveys, and 2 in-person meetings.
A final list of 12 high-priority research topics were generated in the 2 domains. High-priority healthcare-associated infection topics included judicious testing for Clostridioides difficile infection, chlorhexidine (CHG) bathing, measuring and preventing hospital-onset bloodstream infection rates, surgical site infection prevention, surveillance and prevention of multidrug resistant gram-negative rod infections. Antimicrobial stewardship topics included β-lactam allergy de-labeling, judicious use of perioperative antibiotics, intravenous to oral conversion of antimicrobial therapy, developing a patient-level “harm index” for antibiotic exposure, and benchmarking and or peer comparison of antibiotic use for common inpatient conditions.
We identified 6 healthcare-associated infection topics and 6 antimicrobial stewardship topics as potentially high-impact targets for pediatric research.
Gamma-ray burst host galaxies are deficient in molecular gas, and show anomalous metal-poor regions close to GRB positions. Using recent Australia Telescope Compact Array (ATCA) Hi observations we show that they have substantial atomic gas reservoirs. This suggests that star formation in these galaxies may be fuelled by recent inflow of metal-poor atomic gas. While this process is debated, it can happen in low-metallicity gas near the onset of star formation because gas cooling (necessary for star formation) is faster than the Hi-to-H2 conversion.
REM (Rapid Eye Mount) is a fully robotized fast slewing telescope equipped with a high throughput Near InfraRed (Z′, J, H, K′) camera (REMIR) and an optical slitless spectrograph (ROSS). A dedicated software for data reduction and software (AQuA) has been developed to extract scientific information from REM images without any human intervent. REM is installed in La Silla (Chile) and dedicated to detect and study the prompt optical/IR afterglow of Gamma Ray Bursts with the ambitious project of discovering objects at extremely high redshift. The synergy between REMIR camera and ROSS makes REM a powerful observing tool for any kind of fast transient phenomena.
Preliminary results of the 4He relative abundance determination from Radio Recombination Lines observations at different frequencies in the Orion, Rosette and W3 HII regions are presented. The Orion HII region has been mapped at both 22 GHz and 36 GHz with the same beamwidth (2 arcmin) using the Medicina and Puschino radio telescopes respectively. The RRLs parameters, together with their variation with frequency and with distance were determined by centering the map on the star θ1OriC. Three positions were observed in the Rosette HII region at 8.3 GHz leading to the first detection in this region of the transition He92α. The derived 4He relative abundance is considerably greater than the ones obtained from previous measurements. The W3 HII region was observed at 36 GHz and the 4He/H value derived was compared with previous measurements performed with higher spatial resolution.
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