Background. Personality traits have shown considerable
heritable components. Association between
alleles of a polymorphism in the third exon of the dopamine D4 receptor
gene (DRD4) and the
personality trait Novelty Seeking has been reported. Recently, in a sample
non-psychiatric subjects we could not detect any significant relationships
between the same
polymorphism and Novelty Seeking related scales in the Karolinska Scales
of Personality (KSP).
However, there was a tendency in the direction of the proposed association.
There were also
tentative associations between an exon I 13 bp deletion polymorphism and
the personality traits
Socialization and Guilt.
Methods. We investigated a new Swedish population-based sample
(N=167) investigated with the
KSP for three DRD4 polymorphisms.
Results. Neither of the previous results were replicated.
Combining the previous and the present
samples did not give rise to any significant association between DRD4 polymorphisms
Conclusions. The dopamine D4 receptor gene is probably not
of importance to the different
personality dimensions as measured by the Karolinska Scales of Personality.