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2 results

  • Unraveling Molecular Dynamics with High-Speed Video-Rate Atomic Force Microscopy

  • Dimitar R. Stamov, Tanja Neumann, Andreas Kraus, André Körnig, Tilo Jankowski, Detlef Knebel, Torsten Jähnke, Thomas Henze, Heiko Haschke
  • Journal:
    Microscopy Today / Volume 30 / Issue 3 / May 2022
    Published online by Cambridge University Press:
    31 May 2022, pp. 10-14
    Print publication:
    May 2022
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  • This article describes the application of the fastest commercially available video-rate atomic force microscope (AFM) for studying the molecular dynamics of biological samples with a temporal resolution reaching 20 ms per frame. High-speed AFM was used for monitoring the kinetics of the temperature-induced ripple phase transition in supported lipid bilayers, DNA origami streptavidin-biotin binding, thermodynamic rehybridization of DNA, collagen type I fibrillogenesis, and the mobile annexin V trimer dynamics in 2D protein crystals. With no further need for sample processing, the applied method offers a breakthrough in molecular and sample dynamics measurements by enabling the real-time visualization of molecular processes and structural transitions at near-native conditions.