Asthma-obesity is a multifactorial disease, with specific asthma phenotypes which aggravate due to overweight and an unbalanced diet. Futhermore, asthmatic obese are corticotherapy-resistant. This study was to evaluate the effects of an interdisciplinary intervention on food consumption, body composition, lung function and adipokines in obese asthmatic and non-asthmatic adolescents and to investigate the influence of nutrients on lung function. Obese non-asthmatic (n=42) and obese asthmatic (n=21) adolescents of both sexes participated this study. Was evaluated food intake, adiponectin, leptin and C-reactive protein, body composition, asthma symptoms and lung function. The interdisciplinary intervention had the duration of one year and the team consisted of nutritionists, psychologists, physiotherapists, physicians and physical education professionals. After intervention there was a reduction (p≤0.01) in body mass index, body fat percentage, visceral and subcutaneous fat, an increase (p≤0.01) in lean mass and lung function variables in both groups, except the relation between forced expiratory volume in the first second and forced vital capacity (FEV1/FVC) in non-asthmatic. Also, there was lower (p≤0.01) lipid consumption and cholesterol in both groups. The highest energy consumption (β= -0.02) was associated to lower values of forced vital capacity (FVC). Carbohydrate consumption (β= -0.06) and cholesterol were negative predictors (β= -0.05) in FEV1/FVC. The consumption of calcium (β= 0.01), fibers (β= 1.34) and vitamin A (β= 0.01) were positive predictors of FEV1/FVC. Asthma-obesity interdisciplinary treatment promoted improved food consumption and lung function in adolescents and demonstrated that the consumption of nutrients influenced the increase in lung function.