The use of generic sorption data in PA requires the transfer of the data to the PA-specific conditions. A site-specific Kd setting approach for PA calculations was tested, comparing two data transfer procedures. First transfer of sorption data can be done through semi-quantitative estimation procedures, by considering differences between experimental and PA geochemical conditions (sorption capacity, radionuclide speciation, competitive reactions, etc.). On the other hand, thermodynamic sorption models allow to estimate Kd variations directly, based on quasi-mechanistic understanding. The present paper focuses on illustrating example calculations regarding the derivation of Kd values, and their uncertainties, of Cs, Ni, Am and Th, for the mineralogical and geochemical conditions of the mudstone system at the Horonobe URL. Clay minerals (illite and smectite) were considered as sorption-relevant minerals in all cases. The Kd setting results were compared with Kd measured for Horonobe mudstone by batch experiments. The results indicate that Kd can be quantitatively evaluated from generic sorption data when adequate data and models are available. The careful evaluation and conjunctive use of calculated and measured Kd values can enhance the reliability of Kd setting and uncertainty assessments.