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A case–case-control investigation (N = 255 patients) explored the epidemiology of carbapenem-resistant Pseudomonas aeruginosa (CRPA). Recent exposure to carbapenems and a rapidly fatal condition should prompt practitioners to shorten delays in initiating appropriate therapy, which can adversely impact CRPA outcomes, as opposed to the isolated impact of the carbapenem resistance determinant.
This work is part of the interlaboratory collaboration to study the stability of organic solar cells containing PCDTBT polymer as a donor material. The varieties of the OPV devices with different device architectures, electrode materials, encapsulation, and device dimensions were prepared by seven research laboratories. Sets of identical devices were aged according to four different protocols: shelf lifetime, laboratory weathering under simulated illumination at ambient temperature, laboratory weathering under simulated illumination, and elevated temperature (65 °C) and daylight outdoor weathering under sunlight. The results generated in this study allow us to outline several general conclusions related to PCDTBT-based bulk heterojunction (BHJ) solar cells. The results herein reported can be considered as practical guidance for the realization of stabilization approaches in BHJ solar cells containing PCDTBT.
To examine the prevalence of the C677T polymorphism of the methylene tetrahydrofolate reductase (MTHFR) gene and the A2756G polymorphism of methionine synthase (MS), and their impact on antidepressant response.
We screened 224 subjects (52% female, mean age 39 ± 11 years) with SCID-diagnosed major depressive disorder (MDD), and obtained 194 genetic samples. 49 subjects (49% female, mean age 36 ± 11 years) participated in a 12-week open clinical trial of fluoxetine 20–60 mg/day. Association between clinical response and C677T and A2756G polymorphisms, folate, B12, and homocysteine was examined.
Prevalence of the C677T and A2756G polymorphisms was consistent with previous reports (C/C = 41%, C/T = 47%, T/T = 11%, A/A = 66%, A/G = 29%, G/G = 4%). In the fluoxetine-treated subsample (n = 49), intent-to-treat (ITT) response rates were 47% for C/C subjects and 46% for pooled C/T and T/T subjects (nonsignificant). ITT response rates were 38% for A/A subjects and 60% for A/G subjects (nonsignificant), with no subjects exhibiting the G/G homozygote. Mean baseline plasma B12 was significantly lower in A/G subjects compared to A/A, but folate and homocysteine levels were not affected by genetic status. Plasma folate was negatively associated with treatment response.
The C677T and A2756G polymorphisms did not significantly affect antidepressant response. These preliminary findings require replication in larger samples.
In April 2009, 2009 pandemic influenza A (H1N1) (hereafter, pH1N1) virus was identified in California, which caused widespread illness throughout the United States. We evaluated pH1N1 transmission among exposed healthcare personnel (HCP) and assessed the use and effectiveness of personal protective equipment (PPE) early in the outbreak.
Two hospitals and 1 outpatient clinic in Southern California during March 28-April 24, 2009.
Sixty-three HCP exposed to 6 of the first 8 cases of laboratory-confirmed pH1N1 in the United States.
Baseline and follow-up questionnaires were used to collect demographic, epidemiologic, and clinical data. Paired serum samples were obtained to test for pH1N1-specific antibodies by microneutralization and hemagglutination-inhibition assays. Serology results were compared with HCP work setting, role, and self-reported PPE use.
Possible healthcare-associated pH1N1 transmission was identified in 9 (14%) of 63 exposed HCP; 6 (67%) of 9 seropositive HCP had asymptomatic infection. The highest attack rates occurred among outpatient HCP (6/19 [32%]) and among allied health staff (eg, technicians; 8/33 [24%]). Use of mask or N95 respirator was associated with remaining seronegative (P = .047). Adherence to PPE recommendations for preventing transmission of influenza virus and other respiratory pathogens was inadequate, particularly in outpatient settings.
pH1N1 transmission likely occurred in healthcare settings early in the pandemic associated with inadequate PPE use. Organizational support for a comprehensive approach to infectious hazards, including infection prevention training for inpatient- and outpatient-based HCP, is essential to improve HCP and patient safety.
During the five years of the mission, the Gaia spectrograph, the Radial Velocity
Spectrometer (RVS) will repeatedly survey the celestial sphere down to magnitude
V ~ 17–18. This talk presents: (i) the system which is currently developed within
the Gaia Data Processing and Analysis Consortium (DPAC) to reduce and calibrate the
spectra and to derive the radial and rotational velocities, (ii) the RVS expected
performances and (iii) scientific returns.
The calibration of the Radial Velocity Zero-Point (RVZP) of the Radial Velocity
Spectrometer (RVS) will be performed with the help of Radial Velocity (RV) standard stars
and asteroids. A full-sky list of RV standard stars candidates has been built for this
purpose within the Development Unit (DU) 640 of the Gaia DPAC Consortium. A ground-based
campaign of RV observations has been initiated to eliminate unsuitable candidates.
Simulations have also been performed in order to estimate in advance the number of RV
standard stars and asteroids crossing the RVS field of view. These standard stars and
asteroids will also be very helpful for controlling any harmful effect (especially the CCD
radiation damage) on calibration and RVZP during the lifetime of the Gaia project.
Kinematic RV are expected to be published at the end of the project for the brightest
stars, taking into account gravitational redshift and convective shifts for the lines
present in the RVS spectral wavelength range.
The electronic properties of arrays and isolated magnetite nanocrystals were studied using tunneling spectroscopy. Macroscopic tunnel junctions were used to study stacked arrays of the nanocrystals. The temperature dependent resistance measurements showed an abrupt increase of the resistance around 100 K, attributed to the Verwey metal-insulator transition, while the current-voltage characteristics exhibit a sharp transition from an insulator gap to a peak in the density of states near the Fermi energy. This conductance peak was sensitive to in-plane magnetic field showing large magnetoresistance. The tunneling spectra obtained on isolated particles using a Scanning Tunneling Microscope exhibit a gap-like structure below the transition temperature that gradually disappeared with increasing temperature, ending with a small peak structure around zero bias.