We describe the La Silla-QUEST (LSQ) Variability Survey. LSQ is a dedicated wide-field synoptic survey in the Southern Hemisphere, focussing on the discovery and study of transients ranging from low redshift (z < 0.1) SN Ia, Tidal Disruption events, RR Lyræ variables, CVs, Quasars, TNOs and others. The survey utilizes the 1.0-m Schmidt Telescope of the European Southern Observatory at La Silla, Chile, with the large-area QUEST camera, a mosaic of 112 CCDs with field of view of 9.6 square degrees. The LSQ Survey was commissioned in 2009, and is now regularly covering ~1000 square deg per night with a repeat cadence of hours to days. The data are currently processed on a daily basis. We present here a first look at the photometric capabilities of LSQ and we discuss some of the most interesting recent transient detections.