Studies were conducted to compare foliar- and root-based absorption and translocation of SC-0051 in corn and soybean using radio-tracer techniques. Visual injury symptoms expressed in soybean by SC-0051 were bleaching in newly formed (meristematic) tissue followed by necrosis. Corn expressed little to no visual injury. SC-0051 was absorbed more rapidly by foliage of corn and soybean than by their roots. Although soybean absorbed more SC-0051 through roots than did corn, there was no difference between species in foliar absorption of SC-0051. SC-0051 was rapidly translocated throughout corn plants but was concentrated mainly in the meristematic tissue of soybean. Even though there were slight differences in absorption and translocation of SC-0051 in corn and soybean, it is likely that differential metabolism of the herbicide explains selectivity.