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Lisa M. Shin, Department of Psychology Tufts University Medford, MA, USA and Department of Psychiatry Massachusetts General Hospital Harvard Medical School Boston, MA, USA,
Kathryn Handwerger Brohawn, Department of Psychology Tufts University Medford, MA, USA,
Danielle L. Pfaff, Department of Psychology Tufts University Medford, MA, USA,
Roger K. Pitman, Department of Psychiatry Massachusetts General Hospital Harvard Medical School Boston, MA, USA
Post-traumatic stress disorder (PTSD) is an anxiety disorder that can develop in individuals who are exposed to an event or events that involve the threat of death or serious injury, and react with intense fear, helplessness or horror. This chapter summarizes a neurocircuitry model of PTSD and briefly describes the techniques that have been used to study brain function in this disorder. Researchers studying brain function in PTSD have implemented a wide variety of imaging techniques, including positron emission tomography (PET), single photon emission computed tomography (SPECT), and functional magnetic resonance imaging (fMRI). The chapter presents the results of functional neuroimaging studies that have yielded findings relevant to the amygdala, medial prefrontal cortex, and hippocampus in PTSD. It organizes the studies according to both the type of stimuli and the type of imaging technique used.
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