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The COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) project is a large international collaborative effort to analyze individual-level phenotype data from twins in multiple cohorts from different environments. The main objective is to study factors that modify genetic and environmental variation of height, body mass index (BMI, kg/m2) and size at birth, and additionally to address other research questions such as long-term consequences of birth size. The project started in 2013 and is open to all twin projects in the world having height and weight measures on twins with information on zygosity. Thus far, 54 twin projects from 24 countries have provided individual-level data. The CODATwins database includes 489,981 twin individuals (228,635 complete twin pairs). Since many twin cohorts have collected longitudinal data, there is a total of 1,049,785 height and weight observations. For many cohorts, we also have information on birth weight and length, own smoking behavior and own or parental education. We found that the heritability estimates of height and BMI systematically changed from infancy to old age. Remarkably, only minor differences in the heritability estimates were found across cultural–geographic regions, measurement time and birth cohort for height and BMI. In addition to genetic epidemiological studies, we looked at associations of height and BMI with education, birth weight and smoking status. Within-family analyses examined differences within same-sex and opposite-sex dizygotic twins in birth size and later development. The CODATwins project demonstrates the feasibility and value of international collaboration to address gene-by-exposure interactions that require large sample sizes and address the effects of different exposures across time, geographical regions and socioeconomic status.
Objective: Radiation therapy (RT) improves rates of survival of patients with childhood brain tumors but increases deficits in cognition and independent living skills. Previous literature has studied difficulties in basic cognitive processes, but few explore impairment in higher-order skills such as adaptive functioning. Some studies identify females as at risk for cognitive deficits due to RT, but few investigate sex differences in adaptive functioning. It was hypothesized that females would exhibit poorer long-term independent living skills and core cognitive skills relative to males following RT. Methods: Forty-five adult survivors of posterior fossa childhood brain tumors (24 females) completed the Wechsler Abbreviated Scale of Intelligence (WASI-II), Wechsler Memory Scale, Third Edition (WMS-III) Digit Span Forward (DSF) and Backward (DSB), and Oral Symbol Digit Modalities Test (OSDMT). Informants completed the Scales of Independent Behavior-Revised (SIB-R). Results: DSF and OSDMT were positively correlated with all five SIB-R domains, full-scale IQ (FSIQ) was positively correlated with four SIB-R domains, and DSB was positively correlated with three SIB-R domains. There was an interaction between sex and RT for OSDMT and community living skills with trend level interactions for personal living skills and broad independent living skills, where females without RT had higher scores than females with RT. Conclusions: Female survivors were more affected by RT than males across the community living skills domain of adaptive functioning as well as processing speed. Processing speed deficits may have a cascading impact on daily living skills. Future studies should investigate how clinical and biological factors may contribute to personalized treatment plans between sexes. (JINS, 2019, 25, 729–739)
Three-dimensional (3D) printing technology is a promising method for bone tissue engineering applications. For enhanced bone regeneration, it is important to have printable ink materials with appealing properties such as construct interconnectivity, mechanical strength, controlled degradation rates, and the presence of bioactive materials. In this respect, we develop a composite ink composed of polycaprolactone (PCL), poly(D,L-lactide-co-glycolide) (PLGA), and hydroxyapatite particles (HAps) and 3D print it into porous constructs. In vitro study revealed that composite constructs had higher mechanical properties, surface roughness, quicker degradation profile, and cellular behaviors compared to PCL counterparts. Furthermore, in vivo results showed that 3D-printed composite constructs had a positive influence on bone regeneration due to the presence of newly formed mineralized bone tissue and blood vessel formation. Therefore, 3D printable ink made of PCL/PLGA/HAp can be a highly useful material for 3D printing of bone tissue constructs.
OBJECTIVES/SPECIFIC AIMS: The objective of this study is to use machine Learning techniques to generate maps of epithelium and lumen density in MRI space. METHODS/STUDY POPULATION: Methods: We prospectively recruited 39 patients undergoing prostatectomy for this institutional review board (IRB) approved study. Patients underwent MP-MRI before prostatectomy on a 3T field strength MRI scanner (General Electric, Waukesha, WI, USA) using an endorectal coil. MP-MRI included field-of-view optimized and constrained undistorted single shot (FOCUS) diffusion weighted imaging with 10 b-values (b=0, 10, 25, 50, 80, 100, 200, 500, 1000, and 2000), dynamic contrast enhanced imaging, and T2-weighted imaging. T2 weighted images were intensity normalized and apparent diffusion coefficient maps were calculated. The dynamic contrast enhanced data was used to calculate the percent change in signal intensity before and after contrast injection. All images were aligned to the T2 weighted image. Robotic prostatectomy was performed 2 weeks after image acquisition. Prostate samples were sliced using a 3D printed slicing jig matching the slice profile of the T2 weighted image. Whole mount samples at 10 μm thickness were taken, hematoxylin and eosin stained, digitized, and annotated by a board certified pathologist. A total of 210 slides were included in this study. Lumen and epithelium were automatically segmented using a custom algorithm written in MATLAB. The algorithm was validated by comparing manual to automatic segmentation on 18 samples. Slides were aligned with the T2 weighted image using a nonlinear control point warping technique. Lumen and epithelium density and the expert annotation were subsequently transformed into MRI space. Co-registration was validated by applying a known warp to tumor masks noted by the pathologist and control point warping the whole mount slide to match the transform. Overlap was measured using a DICE coefficient. A learning curve was generated to determine the optimal number of patients to train the algorithm on. A PLS algorithm was trained on 150 random permutations of patients incrementing from 1 to 29 patients. Slides were stratified such that all slides from a single patient were in the same cohort. Three cohorts were generated, with tumor burden balanced across all cohort. A PLS algorithm was trained on 2 independent training sets (cohorts 1 and 2) and applied to cohort 3. The input vector consisted of MRI values and the target variable was lumen and epithelium density. The algorithm was trained lesion-wise. Trained PiCT models were applied to the test cohort voxel-wise to generate 2 new image contrasts. Mean lesion values were compared between high grade, low grade, and healthy tissue using an ANOVA. An ROC analysis was performed lesion-wise on the test set. RESULTS/ANTICIPATED RESULTS: Results: The segmentation accuracy validation revealed R=0.99 and R=0.72 (p<0.001) for lumen and epithelium, respectively. The co-registration accuracy revealed a 94.5% overlap. The learning curve stabilized at 10 patients with a root mean square error of 0.14, thus the size of the 2 independent training cohorts was set to 10, leaving 19 for the test cohort. DISCUSSION/SIGNIFICANCE OF IMPACT: We present a technique for combining radiology and pathology with machine learning for generating predictive cytological topography (PiCT) maps of cellularity and lumen density prostate. The voxel-wise approach to mapping cellular features generates 2 new interpretable image contrasts, which can potentially increase confidence in diagnosis or guide biopsy and radiation treatment.
When and to what extent do crises and significant events induce changes in political attitudes? Theories of public opinion and policymaking predict that major events restructure public opinion and pry open new political opportunities. We examine the effect of major events on support for public policies in the context of the Sandy Hook Elementary School mass shooting in December 2012 using a nationally representative panel survey of US adults. Across both cross-sectional and within-subject analyses, we find no evidence that Americans granted greater support for gun control after the Sandy Hook shooting. Our null findings persist across a range of political and demographic groups. We also find no evidence of attitude polarization as a result of Sandy Hook. Our results suggest that elite polarization in a particular issue area leads citizens to employ motivated reasoning when interpreting critical events, thereby reducing the capacity for attitude change. Our findings have important implications for identifying the conditions under which major events affect support for public policies and create political opportunities for policy change.
The discovery of the first electromagnetic counterpart to a gravitational wave signal has generated follow-up observations by over 50 facilities world-wide, ushering in the new era of multi-messenger astronomy. In this paper, we present follow-up observations of the gravitational wave event GW170817 and its electromagnetic counterpart SSS17a/DLT17ck (IAU label AT2017gfo) by 14 Australian telescopes and partner observatories as part of Australian-based and Australian-led research programs. We report early- to late-time multi-wavelength observations, including optical imaging and spectroscopy, mid-infrared imaging, radio imaging, and searches for fast radio bursts. Our optical spectra reveal that the transient source emission cooled from approximately 6 400 K to 2 100 K over a 7-d period and produced no significant optical emission lines. The spectral profiles, cooling rate, and photometric light curves are consistent with the expected outburst and subsequent processes of a binary neutron star merger. Star formation in the host galaxy probably ceased at least a Gyr ago, although there is evidence for a galaxy merger. Binary pulsars with short (100 Myr) decay times are therefore unlikely progenitors, but pulsars like PSR B1534+12 with its 2.7 Gyr coalescence time could produce such a merger. The displacement (~2.2 kpc) of the binary star system from the centre of the main galaxy is not unusual for stars in the host galaxy or stars originating in the merging galaxy, and therefore any constraints on the kick velocity imparted to the progenitor are poor.
Whether monozygotic (MZ) and dizygotic (DZ) twins differ from each other in a variety of phenotypes is important for genetic twin modeling and for inferences made from twin studies in general. We analyzed whether there were differences in individual, maternal and paternal education between MZ and DZ twins in a large pooled dataset. Information was gathered on individual education for 218,362 adult twins from 27 twin cohorts (53% females; 39% MZ twins), and on maternal and paternal education for 147,315 and 143,056 twins respectively, from 28 twin cohorts (52% females; 38% MZ twins). Together, we had information on individual or parental education from 42 twin cohorts representing 19 countries. The original education classifications were transformed to education years and analyzed using linear regression models. Overall, MZ males had 0.26 (95% CI [0.21, 0.31]) years and MZ females 0.17 (95% CI [0.12, 0.21]) years longer education than DZ twins. The zygosity difference became smaller in more recent birth cohorts for both males and females. Parental education was somewhat longer for fathers of DZ twins in cohorts born in 1990–1999 (0.16 years, 95% CI [0.08, 0.25]) and 2000 or later (0.11 years, 95% CI [0.00, 0.22]), compared with fathers of MZ twins. The results show that the years of both individual and parental education are largely similar in MZ and DZ twins. We suggest that the socio-economic differences between MZ and DZ twins are so small that inferences based upon genetic modeling of twin data are not affected.
In the framework of the Surface Heat Budget of the Arctic (SHEBA) study, indirect, non-invasive ice mass-balance measurements were carried out at a drifting station in the northern Chukchi Sea between May and August 1998. Ice thickness was derived from electromagnetic induction (EM) measurements of apparent conductivity along 13 profiles (60−900 m long). As shown through sensitivity studies with a one-dimensional model, the apparent conductivity data from individual points can be inverted to yield estimates of ice thickness and ablation with an accuracy of approximately 0.05 m (for 2 m thick level ice). Ablation rates were 8−18 mm d−1, with total ablation amounting to roughly 0.9−1.2 m. Measurements of thickness and melt rates along different profiles in undeformed multi-year ice corresponded closely, indicating that the sampling statistics are adequate. The roughness of undeformed ice has been found to increase during the summer due to deepening of melt ponds and enhanced bottom melt. Ice under melt ponds was disproportionately thinner, most likely a result of thicker snow cover reducing winter accretion.
Several lines of evidence suggest that the x-ray spectra of quasars are not simple, exact power laws: 1. when Wilkes and Elvis (1987) analyzed quasars as power laws they found an absorption less than that due to our galaxy; 2. The mean 0.3 to 3.5 keV spectral index is steeper than the mean for the 2 to 20 keV range; 3. although several lines of evidence argue that AGN provide a significant portion (perhaps all) of the x-ray background, the diffuse background spectrum does not agree with the x-ray power-law indices measured for quasars or Seyfert galaxies. Schwartz and Tucker (1988) have suggested that all the above conflicts are reconciled if the slope in the Log(flux density) vs. Log(energy) plot flattens continuously with increasing energy. In this paper we utilize one particular parameterization suggested for the flux density, which we call the “log-slope” model:
where f is the flux density, K a normalization parameter which is not of interest here, and a and b are the two parameters of our fit.
Let K be a number field or a function field of characteristic 0, let φ ∈ K(z) with deg(φ) ⩾ 2, and let α ∈ ℙ1(K). Let S be a finite set of places of K containing all the archimedean ones and the primes where φ has bad reduction. After excluding all the natural counterexamples, we define a subset A(φ, α) of ℤ⩾0 × ℤ>0 and show that for all but finitely many (m, n) ∈ A(φ, α) there is a prime 𝔭 ∉ S such that ord𝔭(φm+n(α)−φm(α)) = 1 and α has portrait (m, n) under the action of φ modulo 𝔭. This latter condition implies ord𝔭(φu+v(α)−φu(α)) ⩽ 0 for (u, v) ∈ ℤ⩾0 × ℤ>0 satisfying u < m or v < n. Our proof assumes a conjecture of Vojta for ℙ1 × ℙ1 in the number field case and is unconditional in the function field case thanks to a deep theorem of Yamanoi. This paper extends earlier work of Ingram–Silverman, Faber–Granville and the authors.
The current project seeks to integrate literatures on personality risk for antisocial behavior (ASB) by examining how callous–unemotional traits relate to (a) the development of disinhibited traits and (b) the association between disinhibited traits and ASB. In Study 1, using a nationally representative sample of youth (N > 7,000), we examined whether conduct problems and lack of guilt assessed during ages 4–10 years predicted levels of and changes in disinhibited traits over the course of adolescence, and moderated associations between these traits and ASB. High levels of childhood conduct problems were associated with higher levels of impulsivity, sensation seeking, and ASB in early adolescence, whereas lack of guilt was associated with lower levels of sensation seeking. Neither conduct problems nor lack of guilt significantly predicted changes in impulsivity or sensation seeking, and associations among changes in sensation seeking, impulsivity, and ASB were also consistent across levels of conduct problems and lack of guilt. In Study 2, using a cross-sectional sample of adolescents (N = 970), we tested whether callous–unemotional traits moderated associations between disinhibited traits and ASB. Consistent with the results of Study 1, associations between disinhibited personality and ASB were consistent across a continuous range of callous–unemotional traits.
In order to assess the effect of non-local stress transferral through the ice cover empirically, a linear viscous model (employing both bulk and shear viscosities) is used to predict drift-rates for one Soviet and two U.S. drifting stations over the time period May 1962 to April 1964. The predictions, based on available atmospheric pressure and ocean-current data, are compared to free-drift results and to observed values. The empirical viscosity values giving the best fit to observations show a pronounced seasonal variation that correlates well with the growth rate of thin ice. Drift predictions, especially long-term net drift results, show drift magnitudes and turning angles to be simulated significantly better by a viscous model than by a free-drift model. The effects of steady currents are shown to be small for velocities averaged over days but significant for averages over years.
During March-May 1976, a combination of laser and radar ranging systems was used to study the motion of both the fast ice and the pack ice near Narwhal and Cross Islands, two barrier islands located 16 and 21 km offshore in the vicinity of Prudhoe Bay, Alaska. Laser measurements of targets on the fast ice near Narwhal Island indicate small net displacements of approximately 1 m over the period of study (71 d) with short-term displacements of up to 40 cm occurring over 3 d periods. The main motion was outward normal to the coast and was believed to be the result of thermal expansion of the ice. The radar records of fast-ice sites farther offshore show a systematic increase in the standard deviation of the displacements as measured parallel to the coast, reaching a value of ±6.6 m at 31 km. The farthest fast-ice sites show short-term displacements of up to 12 m. There are also trends in the records that are believed to be the result of the general warming of the fast ice with time.
Radar targets located on the pack ice showed large short-term displacements (up to 2.7 km) but negligible net ice drift along the coast. There was no significant correlation between the movement of the pack and the local wind, suggesting that coastal ice prediction models can only succeed if handled as part of a regional model which incorporates stress transfer through the pack. The apparent fast-ice-pack-ice boundary in the study area was located in 30-35 m of water.
Local ice strains and in situ ice stresses were simultaneously measured on the Coordinated Eastern Arctic Experiment (CEAREX). The experiment took place in the fall of 1988 and was centered about an ice-strengthened ship moored to a multi-year floe in the pack ice northeast of Spitsbergen. During the period of data collection, which extended from early October to late November, the ship and the ice surrounding it drifted from 82°40′N, 32°32′E to 78°54′N, 31°27′E.
As soon as ice temperatures were low enough to permit installation, stress sensors were placed at four sites, two sites on each of two adjacent multi-year floes. Principal stress components and the principal stress direction were determined at each sensor. At the same time, microwave transponders, capable of measuring ice deformation to accuracies better than 1 m, were positioned within 1 km of the stress sensors and provided an approximation of the local strain field.
What makes this joint dataset particularly interesting is that it includes some large ridging events and a particularly large event which terminated the experiment when the multi-year floes in the local area were broken into small fragments. A wide range of ice stresses was measured during the period. The largest compressive stresses, about 250 kPa, were measured by the near-surface sensors. Although sensors in different locations responded differently to ice movement, the large events were common to all shallow sensors.
Cortisol is the primary output of the hypothalamic–pituitary–adrenal (HPA) axis and is central to the biological stress response, with wide-ranging effects on psychiatric health. Despite well-studied biological pathways of glucocorticoid function, little attention has been paid to the role of genetic variation. Conventional salivary, urinary and serum measures are strongly influenced by diurnal variation and transient reactivity. Recently developed technology can be used to measure cortisol accumulation over several months in hair, thus indexing chronic HPA function.
In a socio-economically diverse sample of 1070 twins/multiples (ages 7.80–19.47 years) from the Texas Twin Project, we estimated effects of sex, age and socio-economic status (SES) on hair concentrations of cortisol and its inactive metabolite, cortisone, along with their interactions with genetic and environmental factors. This is the first genetic study of hair neuroendocrine concentrations and the largest twin study of neuroendocrine concentrations in any tissue type.
Glucocorticoid concentrations increased with age for females, but not males. Genetic factors accounted for approximately half of the variation in cortisol and cortisone. Shared environmental effects dissipated over adolescence. Higher SES was related to shallower increases in cortisol with age. SES was unrelated to cortisone, and did not significantly moderate genetic effects on either cortisol or cortisone.
Genetic factors account for sizable proportions of glucocorticoid variation across the entire age range examined, whereas shared environmental influences are modest, and only apparent at earlier ages. Chronic glucocorticoid output appears to be more consistently related to biological sex, age and genotype than to experiential factors that cluster within nuclear families.
This paper presents the first major data release and survey description for the ANU WiFeS SuperNovA Programme. ANU WiFeS SuperNovA Programme is an ongoing supernova spectroscopy campaign utilising the Wide Field Spectrograph on the Australian National University 2.3-m telescope. The first and primary data release of this programme (AWSNAP-DR1) releases 357 spectra of 175 unique objects collected over 82 equivalent full nights of observing from 2012 July to 2015 August. These spectra have been made publicly available via the WISEREP supernova spectroscopy repository.
We analyse the ANU WiFeS SuperNovA Programme sample of Type Ia supernova spectra, including measurements of narrow sodium absorption features afforded by the high spectral resolution of the Wide Field Spectrograph instrument. In some cases, we were able to use the integral-field nature of the Wide Field Spectrograph instrument to measure the rotation velocity of the SN host galaxy near the SN location in order to obtain precision sodium absorption velocities. We also present an extensive time series of SN 2012dn, including a near-nebular spectrum which both confirms its ‘super-Chandrasekhar’ status and enables measurement of the sub-solar host metallicity at the SN site.
The Dark Energy Survey is undertaking an observational programme imaging 1/4 of the southern hemisphere sky with unprecedented photometric accuracy. In the process of observing millions of faint stars and galaxies to constrain the parameters of the dark energy equation of state, the Dark Energy Survey will obtain pre-discovery images of the regions surrounding an estimated 100 gamma-ray bursts over 5 yr. Once gamma-ray bursts are detected by, e.g., the Swift satellite, the DES data will be extremely useful for follow-up observations by the transient astronomy community. We describe a recently-commissioned suite of software that listens continuously for automated notices of gamma-ray burst activity, collates information from archival DES data, and disseminates relevant data products back to the community in near-real-time. Of particular importance are the opportunities that non-public DES data provide for relative photometry of the optical counterparts of gamma-ray bursts, as well as for identifying key characteristics (e.g., photometric redshifts) of potential gamma-ray burst host galaxies. We provide the functional details of the DESAlert software, and its data products, and we show sample results from the application of DESAlert to numerous previously detected gamma-ray bursts, including the possible identification of several heretofore unknown gamma-ray burst hosts.
We generalize Brooks’ theorem to show that if
is a Borel graph on a standard Borel space
of degree bounded by
which contains no
-coloring with respect to any Borel probability measure
, and a Baire measurable
-coloring with respect to any compatible Polish topology on
. The proof of this theorem uses a new technique for constructing one-ended spanning subforests of Borel graphs, as well as ideas from the study of list colorings. We apply the theorem to graphs arising from group actions to obtain factor of IID
-colorings of Cayley graphs of degree
, except in two exceptional cases.
To assess and compare the nutrition environment and practices (as they relate to pre-schoolers) of centre- and home-based child-care facilities.
Using a cross-sectional study design, nineteen child-care facilities (ten centre-based, nine home-based) were assessed for one full day using the Environment and Policy Assessment and Observation (EPAO) tool (consisting of a day-long observation/review of the nutrition environment, practices and related documents). Specifically, eight nutrition-related subscales were considered.
Child-care facilities in London, Ontario, Canada.
Child-care facilities were recruited through directors at centre-based programmes and the providers of home-based programmes.
The mean total nutrition environment EPAO scores for centre- and home-based facilities were 12·3 (sd 1·94) and 10·8 (sd 0·78) out of 20 (where a higher score indicates a more supportive environment with regard to nutrition), respectively. The difference between the total nutrition environment EPAO score for centre- and home-based facilities was approaching significance (P=0·055). For both types of facilities, the highest nutrition subscale score (out of 20) was achieved in the staff behaviours domain (centre mean=17·4; home mean=17·0) and the lowest was in the nutrition training and education domain (centre mean=3·6; home mean=2·0).
Additional research is needed to confirm these findings. In order to better support child-care staff and enhance the overall nutrition environment in child care, modifications to food practices could be adopted. Specifically, the nutritional quality of foods/beverages provided to pre-schoolers could be improved, nutrition-related training for child-care staff could be provided, and a nutrition curriculum could be created to educate pre-schoolers about healthy food choices.
A trend toward greater body size in dizygotic (DZ) than in monozygotic (MZ) twins has been suggested by some but not all studies, and this difference may also vary by age. We analyzed zygosity differences in mean values and variances of height and body mass index (BMI) among male and female twins from infancy to old age. Data were derived from an international database of 54 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins), and included 842,951 height and BMI measurements from twins aged 1 to 102 years. The results showed that DZ twins were consistently taller than MZ twins, with differences of up to 2.0 cm in childhood and adolescence and up to 0.9 cm in adulthood. Similarly, a greater mean BMI of up to 0.3 kg/m2 in childhood and adolescence and up to 0.2 kg/m2 in adulthood was observed in DZ twins, although the pattern was less consistent. DZ twins presented up to 1.7% greater height and 1.9% greater BMI than MZ twins; these percentage differences were largest in middle and late childhood and decreased with age in both sexes. The variance of height was similar in MZ and DZ twins at most ages. In contrast, the variance of BMI was significantly higher in DZ than in MZ twins, particularly in childhood. In conclusion, DZ twins were generally taller and had greater BMI than MZ twins, but the differences decreased with age in both sexes.