We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.
To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure coreplatform@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
‘Dietary variety’ has been identified as a factor associated with food intake. Whilst this relationship may have longer-term benefits for body weight management when eating low-energy, nutrient-dense foods, it may increase the risk of overconsumption (and body adiposity) when foods are high energy density. This study sought to further explore pathways underpinning the relationship between dietary variety and body weight, by considering energy density as a moderating factor and portion size as a mediating factor in this relationship. Using prospective data from the UK Biobank, dietary variety scores (DVS), cumulative portion size and energy density were derived from 24-h dietary recall questionnaires at baseline and follow-up. BMI, whole-body fat percentage and fat-free mass were included as outcomes. Contrary to predictions, linear multiple regression models found some evidence of a negative, direct association between DVS and body weight outcomes at baseline (b = –0·13). Though dietary variety was significantly associated with larger portions across time points (b = 41·86–82·64), a moderated mediation effect was not supported at baseline or follow-up (Index ≤ 0·035). Taken together, these findings provide population-level evidence to support a positive association between variety and food intake, which in turn has potential implications for body weight management, both in terms of moderating food intake and benefitting diet quality.
Members of the New World primate genera Callithrix and Cebuella have specialisations for eating plant exudates. Exudates are also an important component of the diets of many other callitrichid species in the wild, especially at times of nutritional stress. Gum arabic is fed daily to all marmosets and to some tamarins in Jersey Zoo's collection. This study investigated species differences in liking for gum and the effects of the concentration of gum solutions on palatability. As predicted from field data, Callithrix species consumed more gum than other species; Saguinus also showed quite a strong liking for gum. In parallel with data from the wild, lion tamarins (Leontopithecus spp.) consumed the least, and Callimico also took relatively little. The two marmoset species tended to like stronger solutions of gum more than weak solutions and, therefore, the provision of smaller amounts of stronger concentrations is likely to be the most cost-effective way of incorporating gum into the diet. Providing gum to callitrichids on a regular basis can have significant welfare benefits.
Repetitive ‘stereotyped’ behaviours are often performed by both wild and domestic rodents in small laboratory cages. In this study, a behaviour resembling a backwards somersault or backflip is described and quantified in captive roof rats (ship or black rats, Rattus rattus). Videotapes of captive-bred rat pups showed that repetitive backflipping developed rapidly after weaning. In all subjects, the behaviour was highly cyclical, with more than 90 per cent occurring during the dark phase of the light:dark cycle. Individual variability in the performance of backflipping was considerable but performance levels for each individual were consistent from day to day and at 30 and 60 days of age. Highly significant differences were found between litters (families), indicating important maternal and/or genetic effects on performance levels. Cage enrichment in the form of a wooden nest box resulted in dramatically lower rates of performance. Increased cage height resulted in delayed development of backflipping, as well as changes in the form of the behaviour. Results are consistent with the hypothesis that the development and expression of backflipping in young roof rats may be triggered by weaning and maintained by a heightened state of arousal in a relatively impoverished environment with limited opportunities for perceptual and locomotor stimulation.
The formation of the first stars and galaxies during ‘Cosmic Dawn’ is thought to have imparted a faint signal onto the 21-cm spin temperature from atomic Hydrogen gas in the early Universe. Observationally, an absorption feature should be measurable as a frequency dependence in the sky-averaged (i.e. global) temperature at meter wavelengths. This signal should be separable from the smooth—but orders of magnitude brighter—foregrounds by jointly fitting a log-polynomial and absorption trough to radiometer spectra. A majority of approaches to measure the global 21-cm signal use radiometer systems on dipole-like antennas. Here, we argue that beamforming-based methods may allow radio arrays to measure the global 21-cm signal. We simulate an end-to-end drift-scan observation of the radio sky at 50–100 MHz using a zenith-phased array, and find that the complex sidelobe structure introduces a significant frequency-dependent systematic. However, the
$\lambda/D$
evolution of the beam width with frequency does not confound detection. We conclude that a beamformed array with a median sidelobe level
${\sim}-50$
dB may offer an alternative method to measure the global 21-cm signal. This level is achievable by arrays with
$O(10^5)$
antennas.
We investigated the feasibility of recruiting patients unemployed for more than 3 months with chronic pain using a range of methods in primary care in order to conduct a pilot trial of Individual Placement and Support (IPS) to improve quality of life outcomes for people with chronic pain.
Methods:
This research was informed by people with chronic pain. We assessed the feasibility of identification and recruitment of unemployed patients; the training and support needs of employment support workers to integrate with pain services; acceptability of randomisation, retention through follow-up and appropriate outcome measures for a definitive trial. Participants randomised to IPS received integrated support from an employment support worker and a pain occupational therapist to prepare for, and take up, a work placement. Those randomised to Treatment as Usual (TAU) received a bespoke workbook, delivered at an appointment with a research nurse not trained in vocational rehabilitation.
Results:
Using a range of approaches, recruitment through primary care was difficult and resource-intensive (1028 approached to recruit 37 eligible participants). Supplementing recruitment through pain services, another 13 people were recruited (total n = 50). Randomisation to both arms was acceptable: 22 were allocated to IPS and 28 to TAU. Recruited participants were generally not ‘work ready’, particularly if recruited through pain services.
Conclusion:
A definitive randomised controlled trial is not currently feasible for recruiting through primary care in the UK. Although a trial recruiting through pain services might be possible, participants could be unrepresentative in levels of disability and associated health complexities. Retention of participants over 12 months proved challenging, and methods for reducing attrition are required. The intervention has been manualised.
This paper is the fourth in a series of low-frequency searches for technosignatures. Using the Murchison Widefield Array over two nights, we integrate 7 h of data toward the Galactic Centre (centred on the position of Sagittarius
$\mathrm{A}^{*}$
) with a total field-of-view of
$200\,\mathrm{deg}^{2}$
. We present a targeted search toward 144 exoplanetary systems, at our best yet angular resolution (75 arcsec). This is the first technosignature search at a central frequency of 155 MHz toward the Galactic Centre (our previous central frequencies have been lower). A blind search toward in excess of 3 million stars toward the Galactic Centre and Galactic bulge is also completed, placing an equivalent isotropic power limit
$<\!1.1\times10^{19}\,\mathrm{W}$
at the distance to the Galactic Centre. No plausible technosignatures are detected.
To investigate associations between multimodal analgesia and post-operative pain among patients undergoing transoral robotic surgery for oropharyngeal squamous cell carcinoma.
Methods
Records of patients who underwent surgery from 5 September 2012 to 30 November 2016 were abstracted. Associations were assessed using multivariable analysis.
Results
A total of 216 patients (mean age of 59.1 years, 89.4 per cent male) underwent transoral robotic surgery (92.6 per cent were human papilloma virus positive, 87.5 per cent had stage T1–T2 tumours, and 82.9 per cent had stage N0–N1 nodes). Gabapentin (n = 86) was not associated with a reduction in severe pain. Ibuprofen (n = 72) was administered less often in patients with severe pain. Gabapentin was not associated with increased post-operative sedation (p = 0.624) and ibuprofen was not associated with increased bleeding (p = 0.221). Post-operative opioid usage was not associated with surgical duration, pharyngotomy, bilateral neck dissections, tumour stage, tumour size, subsite or gabapentin.
Conclusion
Scheduled low-dose gabapentin was not associated with improved pain control or increased respiratory depression. Ibuprofen was not associated with an increased risk of bleeding and may be under-utilised.
This article looks at the challenges that animist materialism offers to reading strategies in new materialist animal studies scholarship. Where Rosi Braidotti’s vitalist materialism calls for a neoliteral, anti-metaphorical mode of relating to animals, Harry Garuba identifies metaphor as a primary feature of animist materialist practice in African material culture. After critiquing Rosi Braidotti’s dismissal of the “old” metaphorical ways of relating to animals, the article offers a reading of animals and the animist code in two southern African novels, Alex La Guma’s Time of the Butcherbird (1979) and Mia Couto’s The Last Flight of the Flamingo (2000), to consider the potential of animist codings of animals for resisting colonial necropolitics. Animist materialism offers the potential to raise animals and humans into ethical status by affirming the very knowledges and worldviews that Cartesian, colonial humanism wrote off as nonsense and as a marker of inhumanity.
Galactic electron density distribution models are crucial tools for estimating the impact of the ionised interstellar medium on the impulsive signals from radio pulsars and fast radio bursts. The two prevailing Galactic electron density models (GEDMs) are YMW16 (Yao et al. 2017, ApJ, 835, 29) and NE2001 (Cordes & Lazio 2002, arXiv e-prints, pp astro–ph/0207156). Here, we introduce a software package PyGEDM which provides a unified application programming interface for these models and the YT20 (Yamasaki & Totani 2020, ApJ, 888, 105) model of the Galactic halo. We use PyGEDM to compute all-sky maps of Galactic dispersion measure (DM) for YMW16 and NE2001 and compare the large-scale differences between the two. In general, YMW16 predicts higher DM values towards the Galactic anticentre. YMW16 predicts higher DMs at low Galactic latitudes, but NE2001 predicts higher DMs in most other directions. We identify lines of sight for which the models are most discrepant, using pulsars with independent distance measurements. YMW16 performs better on average than NE2001, but both models show significant outliers. We suggest that future campaigns to determine pulsar distances should focus on targets where the models show large discrepancies, so future models can use those measurements to better estimate distances along those line of sight. We also suggest that the Galactic halo should be considered as a component in future GEDMs, to avoid overestimating the Galactic DM contribution for extragalactic sources such as FRBs.
Rigorous scientific review of research protocols is critical to making funding decisions, and to the protection of both human and non-human research participants. Given the increasing complexity of research designs and data analysis methods, quantitative experts, such as biostatisticians, play an essential role in evaluating the rigor and reproducibility of proposed methods. However, there is a common misconception that a statistician’s input is relevant only to sample size/power and statistical analysis sections of a protocol. The comprehensive nature of a biostatistical review coupled with limited guidance on key components of protocol review motived this work. Members of the Biostatistics, Epidemiology, and Research Design Special Interest Group of the Association for Clinical and Translational Science used a consensus approach to identify the elements of research protocols that a biostatistician should consider in a review, and provide specific guidance on how each element should be reviewed. We present the resulting review framework as an educational tool and guideline for biostatisticians navigating review boards and panels. We briefly describe the approach to developing the framework, and we provide a comprehensive checklist and guidance on review of each protocol element. We posit that the biostatistical reviewer, through their breadth of engagement across multiple disciplines and experience with a range of research designs, can and should contribute significantly beyond review of the statistical analysis plan and sample size justification. Through careful scientific review, we hope to prevent excess resource expenditure and risk to humans and animals on poorly planned studies.
We present the first Southern-Hemisphere all-sky imager and radio-transient monitoring system implemented on two prototype stations of the low-frequency component of the Square Kilometre Array (SKA-Low). Since its deployment, the system has been used for real-time monitoring of the recorded commissioning data. Additionally, a transient searching algorithm has been executed on the resulting all-sky images. It uses a difference imaging technique to enable identification of a wide variety of transient classes, ranging from human-made radio-frequency interference to genuine astrophysical events. Observations at the frequency 159.375 MHz and higher in a single coarse channel (
$\approx$
0.926 MHz) were made with 2 s time resolution, and multiple nights were analysed generating thousands of images. Despite having modest sensitivity (
$\sim$
few Jy beam–1), using a single coarse channel and 2-s imaging, the system was able to detect multiple bright transients from PSR B0950+08, proving that it can be used to detect bright transients of an astrophysical origin. The unusual, extreme activity of the pulsar PSR B0950+08 (maximum flux density
$\sim$
155 Jy beam–1) was initially detected in a ‘blind’ search in the 2020 April 10/11 data and later assigned to this specific pulsar. The limitations of our data, however, prevent us from making firm conclusions of the effect being due to a combination of refractive and diffractive scintillation or intrinsic emission mechanisms. The system can routinely collect data over many days without interruptions; the large amount of recorded data at 159.375 and 229.6875 MHz allowed us to determine a preliminary transient surface density upper limit of
$1.32 \times 10^{-9} \text{deg}^{-2}$
for a timescale and limiting flux density of 2 s and 42 Jy, respectively. In the future, we plan to extend the observing bandwidth to tens of MHz and improve time resolution to tens of milliseconds in order to increase the sensitivity and enable detections of fast radio bursts below 300 MHz.
Few studies provide clear rationale for and the reception of adaptations of evidence-based interventions. To address this gap, we describe the context-dependent adaptations in critical time intervention-task shifting (CTI-TS), a manualized recovery program for individuals with psychosis in Rio de Janeiro, Brazil and Santiago, Chile. Implications of the adaptations – incorporating a task-shifting approach and modifying the mode of community-based service delivery – are examined from users' perspectives.
Methods
A secondary analysis of in-depth interviews with CTI-TS users (n = 9 in Brazil; n = 15 in Chile) was conducted. Using the framework method, we thematically compared how participants from each site perceived the main adapted components of CTI-TS.
Results
Users of both sites appreciated the task-shifting worker pair to provide personalized, flexible, and relatable support. They wanted CTI-TS to be longer and experienced difficulty maintaining intervention benefits in the long-term. In Chile, stigma and a perceived professional hierarchy toward the task-shifting providers were more profound than in Brazil. Engagement with community-based services delivery in homes and neighborhoods (Chile), and at community mental health centers (Brazil) were influenced by various personal, familial, financial, and social factors. Uniquely, community violence was a significant barrier to engagement in Brazil.
Conclusion
CTI-TS’ major adaptations were informed by the distinct mental health systems and social context of Santiago and Rio. Evaluation of user experiences with these adaptations provides insights into implementing and scaling-up task-shifting and community-oriented interventions in the region through the creation of specialized roles for the worker pair, targeting sustained intervention effects, and addressing socio-cultural barriers.
Accretion discs appear in many astrophysical systems. In most cases, these discs are probably not completely axisymmetric. Discs in binary systems are often found to be misaligned with respect to the binary orbit. In this case, the gravitational torque from a companion induces nodal precession in misaligned rings of gas. We first calculate whether this precession is strong enough to overcome the internal disc torques communicating angular momentum. For typical parameters, precession torque wins. To check this result, we perform numerical simulations using the Smoothed Particle Hydrodynamics code, PHANTOM, and confirm that sufficiently thin and sufficiently inclined discs can break into distinct planes that precess effectively independently. Disc tearing is widespread and severely changes the disc structure. It enhances dissipation and promotes stronger accretion onto the central object. We also perform a stability analysis on isolated warped discs to understand the physics of disc breaking and tearing observed in numerical simulations. The instability appears in the form of viscous anti-diffusion of the warp amplitude and the surface density. The discovery of disc breaking and tearing has revealed new physical processes that dramatically change the evolution of accretion discs, with obvious implications for observed systems.
NMDA receptor ligands have been shown to rapidly treat depression but are associated with psychotomimetic effects. GLYX-13 is an NMDA receptor glycine site functional partial agonist with ~ 25% of the agonist activity of glycine or Dserine. Animal models suggest a single intravenous dose may produce long-term efficacy without psychotomimetic effects.
Objective
A phase II randomized, double-blind, placebo-controlled trial was conducted to assess the efficacy of GLYX-13 with central raters.
Aim
To examine the effects of a single dose of GLYX-13 in subjects with inadequate response to previous treatment for MDD.
Methods
48 male and 68 female subjects received a single dose of GLYX-13 (1-/5-/10-/30-mg/kg) or placebo. Central raters assessed subjects via telephone using the HDRS-17 at Screening, Baseline, Days 1, 3, 7, 14, 21 and 28.
Results
The a priori primary efficacy ANCOVA on pooled drug dose versus placebo was not significant for change from baseline to Day 1 on HDRS-17 total score. MMRM revealed a statistically significant reduction in HDRS-17 total score versus placebo at Day 3 for 5-mg/kg (−4.4; p < .05) and a trend at Day 1 for 5-mg/kg (−3.5; p = .068) and at Day 7 for 5 and 10-mg/kg (−4.0 for both; p's = .059 and .073). GLYX-13 did not cause psychotomimetic side effects at any dose studied.
Conclusion
This study suggests that GLYX-13, an NMDA receptor glycine site functional partial agonist, rapidly reduces depression scores without eliciting psychotomimetic effects at therapeutic doses as assessed by central raters. Further study is indicated.
We describe an ultra-wide-bandwidth, low-frequency receiver recently installed on the Parkes radio telescope. The receiver system provides continuous frequency coverage from 704 to 4032 MHz. For much of the band (
${\sim}60\%$
), the system temperature is approximately 22 K and the receiver system remains in a linear regime even in the presence of strong mobile phone transmissions. We discuss the scientific and technical aspects of the new receiver, including its astronomical objectives, as well as the feed, receiver, digitiser, and signal processor design. We describe the pipeline routines that form the archive-ready data products and how those data files can be accessed from the archives. The system performance is quantified, including the system noise and linearity, beam shape, antenna efficiency, polarisation calibration, and timing stability.
Single nucleotide polymorphisms (SNPs) contribute small increases in risk for late-onset Alzheimer's disease (LOAD). LOAD SNPs cluster around genes with similar biological functions (pathways). Polygenic risk scores (PRS) aggregate the effect of SNPs genome-wide. However, this approach has not been widely used for SNPs within specific pathways.
Objectives
We investigated whether pathway-specific PRS were significant predictors of LOAD case/control status.
Methods
We mapped SNPs to genes within 8 pathways implicated in LOAD. For our polygenic analysis, the discovery sample comprised 13,831 LOAD cases and 29,877 controls. LOAD risk alleles for SNPs in our 8 pathways were identified at a P-value threshold of 0.5. Pathway-specific PRS were calculated in a target sample of 3332 cases and 9832 controls. The genetic data were pruned with R2 > 0.2 while retaining the SNPs most significantly associated with AD. We tested whether pathway-specific PRS were associated with LOAD using logistic regression, adjusting for age, sex, country, and principal components. We report the proportion of variance in liability explained by each pathway.
Results
The most strongly associated pathways were the immune response (NSNPs = 9304, = 5.63 × 10−19, R2 = 0.04) and hemostasis (NSNPs = 7832, P = 5.47 × 10−7, R2 = 0.015). Regulation of endocytosis, hematopoietic cell lineage, cholesterol transport, clathrin and protein folding were also significantly associated but accounted for less than 1% of the variance. With APOE excluded, all pathways remained significant except proteasome-ubiquitin activity and protein folding.
Conclusions
Genetic risk for LOAD can be split into contributions from different biological pathways. These offer a means to explore disease mechanisms and to stratify patients.
Disclosure of interest
The authors have not supplied their declaration of competing interest.