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A national need is to prepare for and respond to accidental or intentional disasters categorized as chemical, biological, radiological, nuclear, or explosive (CBRNE). These incidents require specific subject-matter expertise, yet have commonalities. We identify 7 core elements comprising CBRNE science that require integration for effective preparedness planning and public health and medical response and recovery. These core elements are (1) basic and clinical sciences, (2) modeling and systems management, (3) planning, (4) response and incident management, (5) recovery and resilience, (6) lessons learned, and (7) continuous improvement. A key feature is the ability of relevant subject matter experts to integrate information into response operations. We propose the CBRNE medical operations science support expert as a professional who (1) understands that CBRNE incidents require an integrated systems approach, (2) understands the key functions and contributions of CBRNE science practitioners, (3) helps direct strategic and tactical CBRNE planning and responses through first-hand experience, and (4) provides advice to senior decision-makers managing response activities. Recognition of both CBRNE science as a distinct competency and the establishment of the CBRNE medical operations science support expert informs the public of the enormous progress made, broadcasts opportunities for new talent, and enhances the sophistication and analytic expertise of senior managers planning for and responding to CBRNE incidents.
We review the various functional cognitive disorders (FCDs) – complaints about memory function or another cognitive process in the absence of relevant neuropathology. These are increasingly coming to the attention of psychiatrists and neurologists and FCD encompasses some newly recognised conditions in addition to classic types such as pseudodementia and psychogenic amnesia. The clinical features, neuropsychological findings and treatment are presented and discussed.
After reading this article you will be able to:
•describe clinical features of FCD and how it differs from neurodegenerative causes of cognitive impairment
•be able to subclassify cases of FCD using the proposed nosology
•understand how to discuss the diagnosis with the patient and explain how the symptoms arise.
We sought to explore factors associated with depressive symptom severity among older persons (≥60 years of age) and to compare the depressive symptoms commonly experienced by older elderly (≥75 years) with those commonly experienced by younger elderly (<75 years).
Secondary analysis was conducted on data from a nationally representative survey.
Four parishes in Jamaica.
A total of 2,943 older community dwellers participated.
The survey included the Zung Self-rating Depression Scale (ZSDS), the Mini Mental State Examination (MMSE), and items on age, sex, and educational level. Linear regression analysis was used to determine the association between ZSDS score and: age, sex, MMSE score, and educational level. Logistic regression analysis was used to determine, for each ZSDS item, whether particular responses were more associated with older or younger elderly.
Higher ZSDS scores were associated with increasing age (B = 0.13, p < 0.001), lower MMSE score (B = −0.42, p < 0.001), the female sex (B = 3.52, p < 0.001), and lower educational level (B = −1.27, p < 0.001). The ZSDS items that were endorsed significantly more (p < 0.05) by older elderly related to negative evaluations about their functionality and value. Hopelessness was also more prominent among the older elderly. The items that were endorsed significantly more (p < 0.05) by the younger elderly had less of a focus.
Among older persons, increasing age was associated with marginally higher levels of depressive symptoms. Female gender, cognitive deficits, preoccupations about value and functionality, and feelings of hopelessness may serve as useful screening parameters.
Autism spectrum disorder (ASD) and obsessive-compulsive disorder (OCD) share abnormalities in hot executive functions such as reward-based decision-making, as measured in the temporal discounting task (TD). No studies, however, have directly compared these disorders to investigate common/distinct neural profiles underlying such abnormalities. We wanted to test whether reward-based decision-making is a shared transdiagnostic feature of both disorders with similar neurofunctional substrates or whether it is a shared phenotype with disorder-differential neurofunctional underpinnings.
Age and IQ-matched boys with ASD (N = 20), with OCD (N = 20) and 20 healthy controls, performed an individually-adjusted functional magnetic resonance imaging (fMRI) TD task. Brain activation and performance were compared between groups.
Boys with ASD showed greater choice-impulsivity than OCD and control boys. Whole-brain between-group comparison revealed shared reductions in ASD and OCD relative to control boys for delayed-immediate choices in right ventromedial/lateral orbitofrontal cortex extending into medial/inferior prefrontal cortex, and in cerebellum, posterior cingulate and precuneus. For immediate-delayed choices, patients relative to controls showed reduced activation in anterior cingulate/ventromedial prefrontal cortex reaching into left caudate, which, at a trend level, was more decreased in ASD than OCD patients, and in bilateral temporal and inferior parietal regions.
This first fMRI comparison between youth with ASD and with OCD, using a reward-based decision-making task, shows predominantly shared neurofunctional abnormalities during TD in key ventromedial, orbital- and inferior fronto-striatal, temporo-parietal and cerebellar regions of temporal foresight and reward processing, suggesting trans-diagnostic neurofunctional deficits.
We aimed to determine the prevalence of alcohol use among older Jamaicans as well as to explore among this population the relationships between alcohol use and: age, sex, depressive symptoms, and life satisfaction. Although the nature of these relationships among the proposed study population were uncertain, in other settings alcohol use has tended to decline with increasing age, occur more commonly among men than women, and show non-linear relationships with depressive symptoms and life satisfaction.
Data gathered by two-stage cluster sampling for a nationally representative health and lifestyle survey of 2,943 community-dwelling older Jamaicans, aged 60 to 103 years, were subjected to secondary analysis using the Student's t-test and χ2 test as appropriate.
Current alcohol use was reported by 21.4% of the participants. It steadily declined with age and was six times more prevalent among men (37.6%) than women (6.2%). These findings were statistically significant as were associations of current alcohol use with comparatively lower levels of depressive symptoms. Current alcohol use was also more prevalent among persons who were either highly satisfied or highly dissatisfied with their lives, compared to others who had levels of life satisfaction between these two extremes.
Current alcohol use among older Jamaicans occurs primarily among men, declines with increasing age, and is associated with a relatively low likelihood of depression. It is also associated with very high and very low levels of life satisfaction.
Genetically similar nulliparous Polled Hereford heifers from a closed pedigree herd were used to evaluate the effects of dietary protein during the first and second trimester of gestation upon foetal, placental and postnatal growth. Heifers were randomly allocated into two groups at 35 days after artificial insemination (35 days post conception (dpc)) to a single bull and fed high (15.7% CP) or low (5.9% CP) protein in the first trimester (T1). At 90 dpc, half of each nutritional treatment group changed to a high- or low-protein diet for the second trimester until 180 dpc (T2). High protein intake in the second trimester increased birth weight in females (P=0.05), but there was no effect of treatment upon birth weight when taken over both sexes. Biparietal diameter was significantly increased by high protein in the second trimester with the effect being greater in the female (P=0.02), but also significant overall (P=0.05). Placental weight was positively correlated with birth weight, fibroblast volume and relative blood vessel volume (P<0.05). Placental fibroblast density was increased and trophoblast volume decreased in the high-protein first trimester treatment group (P<0.05). There was a trend for placental weight to be increased by high protein in the second trimester (P=0.06). Calves from heifers fed the high-protein treatment in the second trimester weighed significantly more on all occasions preweaning (at 1 month (P=0.0004), 2 months (P=0.006), 3 months (P=0.002), 4 months (P=0.01), 5 months (P=0.03), 6 months (P=0.001)), and grew at a faster rate over the 6-month period. By 6 months of age, the calves from heifers fed high nutrition in the second trimester weighed 33 kg heavier than those fed the low diet in the second trimester. These results suggest that dietary protein in early pregnancy alters the development of the bovine placenta and calf growth to weaning.
How should a review of Singapore in 2015 be best framed? By an acronym and a number: SG50. This was the year Singapore celebrated its fiftieth year of independence, with the ubiquitous SG50 logo embossed on and attached to almost anything. Much like an individual turning middle-aged, the year was one where the nation experienced loss, made decisions about its future, reflected on and celebrated its past with pride, and tried to become comfortable with its own skin.
Domestic Political Developments
National Loss: The Passing of Lee Kuan Yew
Loss in 2015 for the nation came in the form of the death of former Prime Minister Lee Kuan Yew on 23 March at the age of ninety-one — just under five months before the city-state was to celebrate fifty years of independence. Lee passed away after being hospitalized for severe pneumonia on 5 February. Lee's elder son, Prime Minister Lee Hsien Loong, declared a week-long period of national mourning and all national flags were flown at half mast during that period. After a private wake, his body was moved to the Parliament House of Singapore on 25 March where he lay in state for four days before his cremation on 29 March.
Lee's death has undoubtedly closed a chapter in Singapore's history, as he is widely regarded as the key founding father of modern Singapore. Co-founder of the People's Action Party (PAP), the political party that has governed Singapore uninterrupted since home rule in 1959, Lee was Singapore's first and longest-serving Prime Minister. He oversaw the rapid development of the nation in one generation from underdeveloped to developed status. In a televised address to the nation on the day of his father's death, Prime Minister Lee maintained “[t]o many Singaporeans, and indeed others too, Lee Kuan Yew was Singapore”. The immense measure of the man and the intimacy of the ties between him and the nation may be found in the tributes paid from abroad, the number of people who queued for hours to pay their respects when he lay in state and the numbers who lined the roads to see the cortege travel to the funeral service and the crematorium.
The purpose of this article is to set forth some ethical practice guidelines for human service workers with less than professional qualifications.’ The growing awareness of social, behavioural and mental health problems in our society ranging from hyper-active children who cannot read to depressed housewives who cannot cope, has resulted in the need for more personnel in the human service fields. Increasingly, the helping professionals have been aided and abetted in their work by a growing number of aids or assistants who work undertheirdirection inthefields of psychiatry, psychology, social work, nursing, the ministry, the law and vocational and educational counselling. Sometimes referred to as the “new careers worker” (Golann and Eisdorfer: 1972) or the “new professional” (Dugger: 1975), such workers may have some preparation, some on-the-job staff development, but will have less than the traditional professional training. Among these workers are many individuals, mostly women who are utilized for their nurturing, home-making skills so important in residential settings for children and in foster homes. There are also workers who are indigenous to low-income or minority group areas who possess important knowledge for promoting programs and special skills at case finding. (Pearl and Reissman: 1965) In addition there are volunteers of all kinds, including former clients, working in both conventional and atypical agencies. Honorary Probationary Officers alone number approximately 900 in Victoria in 1980 and constitute a major support for individuals on probation. All of these workers face, just as professionals do, complex and ambiguous ethical questions.
Objective: Idiopathic normal pressure hydrocephalus (INPH) is a neurological disorder presenting with gait, cognitive, and bladder symptoms in the context of ventricular enlargement. Although gait is the primary indicator for treatment candidacy and outcome, additional monitoring tools are needed. Line Tracing Test (LTT) and Serial Dotting Test (SDT), two psychomotor tasks, have been introduced as potential outcome measures but have not been widely studied. This preliminary study examined whether LTT and SDT are sensitive to motor dysfunction in INPH and determined if accuracy and time are important aspects of performance. Methods: Eighty-four INPH subjects and 36 healthy older adults were administered LTT and SDT. Novel error scoring procedures were developed to make scoring practical and efficient; interclass correlation showed good reliability of scoring procedures for both tasks (0.997; p<.001). Results: The INPH group demonstrated slower performance on SDT (p<.001) and made a greater number of errors on both tasks (p<.001). Combined Time/Error scores revealed poorer performance in the INPH group for original-LTT (p<.001), modified-LTT (p≤.001) and SDT (p<.001). Conclusions: These findings indicate LTT and SDT may prove useful for monitoring psychomotor skills in INPH. While completion time reflects impaired processing speed, reduced accuracy may suggest planning and self-monitoring difficulties, aspects of executive functioning known to be compromised in INPH. This is the first study to underscore the importance of performance accuracy in INPH and introduce practical/reliable error scoring for these tasks. Future work will establish reliability and validity of these measures and determine their utility as outcome tools. (JINS, 2016, 22, 341–349)
Given the capacity of ruminants to modify diet selection based on metabolic needs, we hypothesised that, when given a choice, lambs experiencing a vitamin E deficiency would consume more of a vitamin E-enriched feed than lambs not deficient in vitamin E. Fifty-six Dohne Merino lambs were divided into two groups and fed either a vitamin E-deficient diet over 40 days to induce low plasma vitamin E or a vitamin E-enriched diet to induce high plasma vitamin E. The lambs were then offered a choice of vitamin E-enriched and vitamin E-deficient pellets. For half of the animals, the enriched diet was paired with strawberry flavour and the deficient diet was paired with orange flavour, while the reverse pairings were offered to the others. Lamb preference for the diets was measured daily for the following 15 days. There was a three-way interaction between the high and low vitamin E treatment groups×vitamin E content and type of flavour in the feed×time (days). The lambs preferred pellets flavoured with strawberry but this preference changed to orange flavour in vitamin E-deficient lambs if the orange flavour was paired with high vitamin E. Lambs without a deficiency continued to prefer strawberry-flavoured pellets, regardless of the vitamin E concentrations in the pellets. It is possible that self-learning contributed to the low vitamin E group of lambs changing preference to orange flavour in order to consume more vitamin E, presumably to remediate the deficiency.
Recent molecular studies have proved beneficial in providing taxonomic resolution within the Octopus vulgaris species complex, therefore aiding in the appropriate management of this high value global fisheries resource. This study used the mitochondrial ‘barcode of life’ gene Cytochrome Oxidase subunit I (COI) to investigate the identity of shallow-water benthic octopuses in the mid-Atlantic Ocean and their relationship to members of the Octopus vulgaris species complex. Maximum likelihood and Bayesian phylogenetic inference placed individuals collected from two tropical islands, Ascension and St Helena, into a highly supported monophyletic clade with the North Brazilian species O. insularis (BS = 81, PP = 1), extending the known distribution of O. insularis to Ascension and St Helena Islands. Octopus vulgaris and two other member species of the O. vulgaris species complex, O. tetricus and O. cf. tetricus formed a highly supported monophyletic clade (BS = 99, PP = 1). Interspecific distances between the O. mimus group (O. mimus, O. bimaculoides, O. maya and O. insularis) and the O. vulgaris species group (O. vulgaris, O. tetricus and O. cf. tetricus) ranged from 14.7–26.0%, and an estimated date of divergence suggests these groups diverged from a common ancestor between 19.0 and 40.9 million years ago.
While regular astronomical image archive searches can find images at a fixed location, they cannot find images of moving targets such as asteroids or comets. The Solar System Object Image Search (SSOIS) at the Canadian Astronomy Data Centre allows users to search for images of moving objects, allowing precoveries. SSOIS accepts as input either an object designation, a list of observations, a set of orbital elements, or a user-generated ephemeris for an object. It then searches for observations of that object over a range of dates. The user is then presented with a list of images containing that object from a variety of archives. Initially created to search the CFHT MegaCam archive, SSOIS has been extended to other telescopes including Gemini, Subaru/SuprimeCam, WISE, HST, the SDSS, AAT, the ING telescopes, the ESO telescopes, and the NOAO telescopes (KPNO/CTIO/WIYN), for a total of 24.5 million images. As the Pan-STARRS and Hyper Suprime-Cam archives become available, they will be incorporated as well. The SSOIS tool is located on the web at http://www.cadc-ccda.hia-iha.nrc-cnrc.gc.ca/en/ssois/.