Four experiments were conducted to develop controls for downy brome (Bromus tectorum L.) in winter wheat (Triticum aestivum L. ‘Gaines’). In three experiments downy brome was removed at monthly intervals from emergence to harvest. In the third and fourth experiments, hand weeded and weedy controls were compared to chemical control with R11913 (3′-hydroxypropionanilide isopropylcarbamate). Downy brome, which emerged with wheat, was most competitive during March of each year. For maximum effectiveness, R11913 should be applied when downy brome has less than one to three tillers or chemical control will be erratic. On a silt loam soil with an average annual precipitation of 42 cm, downy brome densities of 108 to 160 plants/m2 lowered wheat yields 6% when competition was eliminated by March. When competition was permitted until wheat harvest (July), yield was reduced 40%.