Within its sociotherapeutical programme St. John Psychiatric Hospital has been continuously since 1963 conducting the treatment and rehabilitation of psychiatric patients accommodated in heterogeneous families according to the Belgian model. Research conducted in the West as well as the experience gained at our hospital suggests that this sociotherapeutical method is very effective in the process of prolonged treatment, rehabilitation and resocialisation as well as the improvement of the quality of life of psychiatric patients. The ultimate objective of this investigation was to examine the quality of life of the groups of schizophrenic and depressive patients under observation, and the impact of a heterogeneous family, primary or secondary family and hospital ambient on the process of treatment and rehabilitation. The assumption is that in the process of prolonged treatment patients accommodated in heterogeneous families psychosocially function better and attain a higher quality of life than those who are under long-term outpatient treatment and live with the primary or secondary family or, alternatively, have been hospitalised. Applied was a comparative method of investigating groups of patients affected by schizophrenia and depression that were in the process of prolonged treatment accommodated in heterogeneous families, primary or secondary family, or those who were hospitalised. Individually assessed by way of appropriate questionnaires, completed by the very subjects, were the health-related quality of life and the subjective quality of life.