Wide-angle surveys at different wavelengths are already providing triggers for very different kinds of transients. The most interesting science is produced when new sources are followed-up and characterised by using the right instrumentation, telescopes and observing strategies. In the coming years, with new large-scale surveys such as ZTF and LSST, the amount of triggers is expected to scale up massively. Furthermore, new observational windows, such as gravitational waves or neutrinos, are now opening and adding complexity to the picture. The instrumentation and strategies that we have been using over recent years may just not be appropriate for those new situations. In this Workshop we discussed the present and projected future of transient discovery, the instrumentation that will be needed for the follow-up of those targets, and the observing strategies, data analysis and community efforts that will be required to tackle the challenges that lie ahead of us.