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Children of parents with mood and psychotic disorders are at elevated risk for a range of behavioral and emotional problems. However, as the usual reporter of psychopathology in children is the parent, reports of early problems in children of parents with mood and psychotic disorders may be biased by the parents' own experience of mental illness and their mental state.
Independent observers rated psychopathology using the Test Observation Form in 378 children and youth between the ages of 4 and 24 (mean = 11.01, s.d. = 4.40) who had a parent with major depressive disorder, bipolar disorder, schizophrenia, or no history of mood and psychotic disorders.
Observed attentional problems were elevated in offspring of parents with major depressive disorder, bipolar disorder and schizophrenia (effect sizes ranging between 0.31 and 0.56). Oppositional behavior and language/thought problems showed variable degrees of elevation (effect sizes 0.17 to 0.57) across the three high-risk groups, with the greatest difficulties observed in offspring of parents with bipolar disorder. Observed anxiety was increased in offspring of parents with major depressive disorder and bipolar disorder (effect sizes 0.19 and 0.25 respectively) but not in offspring of parents with schizophrenia.
Our results suggest that externalizing problems and cognitive and language difficulties may represent a general manifestation of familial risk for mood and psychotic disorders, while anxiety may be a specific marker of liability for mood disorders. Observer assessment may improve early identification of risk and selection of youth who may benefit from targeted prevention.
We compared antibiotic prescribing to older people in different settings to inform antibiotic stewardship interventions. We used data linkage to stratify individuals aged 65 years and over in Northern Ireland, 1st January 2012–31st December 2013, by residence: community dwelling, care home dwelling or ‘transitioned’ if admitted to a care home. The odds of being prescribed an antibiotic by residence were analysed using logistic regression, adjusting for patient demographics and selected medication use (proxy for co-morbidities). Trends in monthly antibiotic prescribing were examined in the 6 months pre- and post-admission to the care home. The odds of being prescribed at least one antibiotic were twofold higher in care homes compared with community dwellers (adjusted odds ratio 2.05, 95% CI 1.93–2.17). There was a proportionate increase of 51.5% in the percentage prescribed an antibiotic on admission, with a monthly average of 23% receiving an antibiotic in the 6 months post admission. While clinical need likely accounts for some of the observed antibiotic prescribing in care homes we cannot rule out more liberal prescribing, given the twofold difference between care home residents and their community dwelling peers having accounted for co-morbidities. The appropriateness of antibiotic prescribing in the care home setting should be examined.
We aimed to quantify the proportion of people receiving care for HIV-infection that are 50 years or older (older HIV patients) in Latin America and the Caribbean between 2000 and 2015 and to estimate the contribution to the growth of this population of people enrolled before (<50yo) and after 50 years old (yo) (⩾50yo). We used a series of repeated, cross-sectional measurements over time in the Caribbean, Central and South American network (CCASAnet) cohort. We estimated the percentage of patients retained in care each year that were older HIV patients. For every calendar year, we divided patients into two groups: those who enrolled before age 50 and after age 50. We used logistic regression models to estimate the change in the proportion of older HIV patients between 2000 and 2015. The percentage of CCASAnet HIV patients over 50 years had a threefold increase (8% to 24%) between 2000 and 2015. Most of the growth of this population can be explained by the increasing proportion of people that enrolled before 50 years and aged in care. These changes will impact needs of care for people living with HIV, due to multiple comorbidities and high risk of disability associated with aging.
The Northern Ireland beef herd currently incorporates a very diverse range of genotypes which produces a very varied product in terms of carcass weight, fatness and conformation (Kirkland et al., 2004). However, factors other than genotype may also influence the expression of maternal traits and progeny carcass characteristics. The objective of the present study was to evaluate the influence of dam conformation, irrespective of genotype, on dystocia and progeny carcass traits.
In contrast to the Holstein-Friesian (HF) breed, Norwegian dairy cattle (NC) have been selected with emphasis on disease resistance and beef characteristics as well as milk production, and hence may be more suited to beef production than high genetic merit Holstein animals. The objective of this study was to evaluate the beef production potential of NC bulls, and to compare their performance with that of HF bulls.
The suckler beef industry in Northern Ireland comprises many differing dam breeds and breed crosses. However, there is a paucity of data on the influence of dam breed on parameters such as carcass weight, fatness and conformation, and on factors affecting management of the herd (e.g. dystocia and fertility). The latter are particularly important in view of the increasing number of part time beef farmers in Northern Ireland. The objective of the present study was to evaluate the influence of dam breed on production characteristics of the suckler herd in Northern Ireland.
Meat from Holstein-Friesian bulls, which are bred for dairy traits, is generally regarded as low quality and is usually destined for the commodity (mince) market. However, given their ready availability as a by-product from the dairy herd, it is important to determine if meat from these animals would be suited to higher-priced markets. Furthermore, meat from bulls is generally considered to be lower quality than that from steers, though there is a paucity of data comparing meat from both sources. Hence, the objective of this study was to evaluate the effect of slaughter weight on meat quality characteristics of Holstein-Friesian bulls and steers offered a cereal-based ration.
A considerable proportion of beef produced in the UK is a byproduct of the dairy industry. Young animals from this source are generally regarded as low in quality and meat from animals of this type is usually destined for the commodity minced beef market. The objective of the present study was to evaluate the effect of slaughter weight on sensory characteristics of meat from Holstein-Friesian bulls and steers offered a cereal-based ration.
Empty body (EB) weight (EBW) is used to estimate the energy and protein requirements for maintenance for dairy cattle. It is predicted from live weight (LW), but the prediction can be influenced by a number of factors, e.g., feed and water intake, pregnancy and body condition. The objective of the present study was to develop prediction equations for EBW and carcass weight in lactating dairy cows using LW and other live animal data.
The commercial value of beef carcasses can be assessed by several methods including the yield of primal joints and meat quality characteristics. However, it is also important to determine the composition of the carcass in terms of lean, fat and bone concentrations, and to evaluate individual fat components of the carcass, to provide an overall assessment of the commercial value of the carcass. The objective of the present study was to evaluate the effect of slaughter weight on carcass composition of Holstein-Friesian bulls and steers offered cereal-based rations.
Iodine value (IV) indicates the degree of unsaturation of milk fat, thus reflecting the presence of long chain unsaturated fatty acids (LCUFA), especially C18:1c. The higher the IV the greater the degree of unsaturation. Changes in dietary lipid content and composition can have a major effect on the IV of milk fat. The principal fatty acid in the forage component of the diet, namely grass or grass silage, is C18:3 (Murphy, 2000) while concentrate supplements contain varying proportions of C18:1 or C18:2 fatty acids. LCUFA undergo hydrolysis and biohydrogenation in the cow’s rumen producing mainly C18:0, the majority of which is converted to C18:1c by the desaturase enzyme systems, mainly in the mammary gland (Murphy, 2000). This experiment aimed to examine the relationship between milk fat IV and dietary lipid content, composition and diet type.
San Pietro and Rittenberg (1953) reported that urea appeared to meet all the requirements of a satisfactory tracer. Urea is non toxic, not foreign to the body and it shows an even and rapid distribution throughout the total body water without any physiological effect. For these reasons in addition to its easy and accurate measurement, urea is an ideal candidate tracer to estimate empty body water in vivo. Total body water volume (urea space) can be estimated by dividing the total amount of urea infused by the increase in plasma urea concentration from prior to infusion until 12 or 30 minutes after mean infusion time. Kock and Preston (1973) reported significant relationships between urea space measurements and percentage of empty body fat and water in cattle. However, Andrew et al. (1995) using 21 Holstein cows showed that prediction of empty body water using the urea space technique only explained 31 % of the variation. The objective of this experiment was to use the urea dilution technique to estimate the body composition of lactating dairy cows and produce relationships between urea space and body fat and protein content.
With increasing Holsteinisation of the dairy herd, the milk production potential of dairy cows has increased substantially over the past two decades. This development presents new challenges for managing dairy cows during grazing, particularly where the objective is to maximise the proportion of energy in the diet derived from forage (Mayne and Peyraud, 1996). The objective of the current study was to explore forage supplementation strategies to maintain high milk yields from grass and forage in dairy cows during the grazing season. A second objective of the study was to examine the effect of concentrates of contrasting degradability on milk production.
Fruit and vegetable (FV) intake is associated with reduced risk of a number of non-communicable diseases. Research tends to focus on antioxidants, flavonoids and polyphenols contained in FV as the main beneficial components to health; however, increasing FV may also alter overall diet profile. Extra FV may be substituted for foods thought to be less healthy, therefore altering the overall macronutrient and/or micronutrient content in the diet. This analysis merged dietary data from four intervention studies in participants with varying health conditions and examined the effect of increased FV consumption on diet profile. Dietary intake was assessed by either diet diaries or diet histories used in four FV randomised intervention studies. All food and drink intake recorded was analysed using WISP version 3.0, and FV portions were manually counted using household measures. Regression analysis revealed significant increases in intakes of energy (172 kJ (+41 kcal)), carbohydrate (+3·9 g/4184 kJ (1000 kcal)), total sugars (+6·0 g/4184 kJ (1000 kcal)) and fibre (+0·8 g/4184 kJ (1000 kcal)) and significant decreases in intakes of total fat (−1·4 g/4184 kJ (1000 kcal)), SFA (−0·6 g/4184 kJ (1000 kcal)), MUFA (−0·6 g/4184 kJ (1000 kcal)), PUFA (−0·1 g/4184 kJ (1000 kcal)) and starch (−2·1 g/4184 kJ (1000 kcal)) per one portion increase in FV. Significant percentage increases were also observed in vitamin C (+24 %) and -carotene (+20 %) intake, per one portion increase in FV. In conclusion, pooled analysis of four FV intervention studies, that used similar approaches to achieving dietary change, in participants with varying health conditions, demonstrated an increase in energy, total carbohydrate, sugars and fibre intake, and a decrease in fat intake alongside an expected increase in micronutrient intake.
Cortisol is the primary output of the hypothalamic–pituitary–adrenal (HPA) axis and is central to the biological stress response, with wide-ranging effects on psychiatric health. Despite well-studied biological pathways of glucocorticoid function, little attention has been paid to the role of genetic variation. Conventional salivary, urinary and serum measures are strongly influenced by diurnal variation and transient reactivity. Recently developed technology can be used to measure cortisol accumulation over several months in hair, thus indexing chronic HPA function.
In a socio-economically diverse sample of 1070 twins/multiples (ages 7.80–19.47 years) from the Texas Twin Project, we estimated effects of sex, age and socio-economic status (SES) on hair concentrations of cortisol and its inactive metabolite, cortisone, along with their interactions with genetic and environmental factors. This is the first genetic study of hair neuroendocrine concentrations and the largest twin study of neuroendocrine concentrations in any tissue type.
Glucocorticoid concentrations increased with age for females, but not males. Genetic factors accounted for approximately half of the variation in cortisol and cortisone. Shared environmental effects dissipated over adolescence. Higher SES was related to shallower increases in cortisol with age. SES was unrelated to cortisone, and did not significantly moderate genetic effects on either cortisol or cortisone.
Genetic factors account for sizable proportions of glucocorticoid variation across the entire age range examined, whereas shared environmental influences are modest, and only apparent at earlier ages. Chronic glucocorticoid output appears to be more consistently related to biological sex, age and genotype than to experiential factors that cluster within nuclear families.