Simulators are very effective in healthcare education, and they can be used for teaching the safe administration of sedation and/or analgesia. There are several classifications of simulators. One of them is based on the media used in simulation. This classification divides all simulators into two major categories: computer screen-based simulators and mannequin-based simulators. The following are the main high-fidelity mannequin-based computer-driven simulators utilized for teaching procedural sedation and analgesia: Laerdal SimMan simulators; Medical Education Technologies (METI) simulators; and Gaumard simulators. METI simulators have the most elaborate design, with built-in physiologic and pharmacologic systems that can be used for modeling different clinical conditions, and they have a sophisticated scenario editor/player. Laerdal SimMan simulators have advanced programming features that allow them to run preprogrammed scenarios as well as to be used on the fly. Any simulator is capable of delivering an exciting and valuable educational experience to both the trainees and instructors.