Our knowledge of the life of Francesco Zambeccari, the noted translator and fabricator of the letters of Libanius, is sketchy at best, and the course of his later years is shrouded in mystery. In 1474 he is known to have taught Greek and Latin literature in Perugia, and in the following year to have obtained a position with King Ferdinand I of Naples.
But when Zambeccari left Perugia, probably in April 1475, he went to Rome and not to Naples, for Ferdinand had already come to Rome to take part in the celebration of the seventh jubilee year of that city. While in Rome Zambeccari worked on his translations of the Libanian letters and consulted with Johannes Argyropoulos concerning them. Here every trace of Zambeccari ends. It is not known whether he ever went to Naples; Foerster's investigations of the archives at Naples and of contemporary letters of prominent Neapolitans have produced only negative results.