To send content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about sending content to .
To send content items to your Kindle, first ensure email@example.com
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about sending to your Kindle.
Note you can select to send to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
Cognitive impairment precedes the diagnosis of Alzheimer's disease. It is unclear which psychometric measures predict dementia, and what cut-off points should be used. Replicable cognitive measures to provide information about differential diagnosis and prognosis would be clinically useful.
In a prospective cohort study we investigated which measures distinguish between individuals with amnestic mild cognitive impairment (aMCI) that converts to dementia and those whose impairment does not, and which combination of measures best predicts the fate of people with aMCI.
Forty-four participants with aMCI underwent extensive neuropsychological assessment at baseline and annually thereafter for an average of 4 years. Differences in baseline cognitive performance of participants who were converters and non-converters to clinically diagnosed dementia were analysed. Classification accuracy was estimated by sensitivity, specificity, positive and negative predictive values and using logistic regression.
Forty-one percent of participants had progressed to dementia by the end of study, with a mean annual conversion rate of 11%. Most (63%) showed persisting or progressive cognitive impairment, irrespective of diagnosis. The Addenbrooke's Cognitive Examination together with the discrimination index of the Hopkins Verbal Learning Test – Revised (but none of the demographic indices) differentiated the participants who were converters from the non-converters at baseline with 74% accuracy.
Targeted neuropsychological assessment, beyond simple cognitive screening, could be used in clinical practice to provide individuals with aMCI with prognostic information and aid selective early initiation of monitoring and treatment among those who progress towards a clinically diagnosable dementia.
There is current interest in exploring the different subtypes of mild
cognitive impairment (MCI), in terms of both their epidemiology and their
To examine the frequency of MCI subtypes presenting to a memory clinic
and to document detailed neuropsychological profiles of patients with the
Consecutive tertiary referrals (n = 187) were
psychiatrically evaluated; 45 patients met criteria for amnestic mild
cognitive impairment (aMCI). A subgroup of 33 patients with aMCI as well
as 21 healthy controls took part in a thorough neuropsychological
Of the patients who were examined in greater neuropsychological detail,
ten had pure aMCI (none with visual memory impairment only). Fifteen met
criteria for non-amnestic MCI. Fifteen had normal neuropsychological
profiles. Using more than one test increased sensitivity to detect
episodic memory impairment.
Amnestic MCI is an important diagnosis in secondary and tertiary memory
clinics. There is scope to improve the efficacy and sensitivity of the
clinical assessment of this impairment.
Email your librarian or administrator to recommend adding this to your organisation's collection.