Ink jet technology is applied to the industry application of CPU cooling in this study. The PZT actuated micro-cooling device which generating the micro-scale liquid droplet is used in the CPU cooling of desktop and laptop PCs. It consists the advantages of long lifetime of operation, simple and easily manufactured of the structure with PZT actuator. Since the high latent heat transfer rate, 2260 J/g, of water droplet for the liquid-vapor phase change cooling system, it removes heat from the CPU surface effectively for over 100 W. In order to design an efficient cooling device, it is important to study the PZT material property varies after the laser cutting process and the dimensional effects of PZT actuator on the nozzle plate vibration mode. The frequency and amplitude of the voltage used to energize the PZT transducer are also important parameters that should be properly controlled in order to achieve the optimal liquid breakup conditions. It also reveals the low noise and power consumption in the CPU cooling system with some appropriate operational conditions.