Cyber-Physical-Systems provide extensive data gathering opportunities along the lifecycle, enabling data-driven design to improve the design process. However, its implementation faces challenges, particularly in the initial data capturing stage. To identify those, a comprehensive approach combining a systematic literature review and an industry survey was applied. Four groups of interrelated challenges were identified as most relevant to practitioners: data selection, data availability in systems, knowledge about data science processes and tools, and guiding users in targeted data capturing.

Digital transformation increases the need for interdisciplinary collaboration along the product lifecycle. It is currently hindered by a low data consistency resulting from the use of heterogeneous systems and data models. Especially in work planning, where several data models are combined, this decreases efficiency. Systems Lifecycle management (SysLM) offers a solution to this remedy. However, a sudden switch to SysLM is not possible in brownfields. Thus, it is necessary to examine the challenges and opportunities to derive case-specific measures that enable its adoption in work planning.

Background: Increasing attention has been given to subtyping OCD with respect to different clinical profiles, response to drug treatments, comorbidity and age of onset. There are a number of studies looking at predictors of treatment outcome in OCD, but so far not for OCD subtypes. Method: Prediction of outcome after cognitive-behavioural therapy was evaluated in 63 inpatients with early obsessive-compulsive disorder (EOCD ≤ 12 years of age) and 191 patients with late obsessive-compulsive disorder (LOCD > 15 years of age). Results: For EOCD patients factors predicting a good outcome included high motivation and high initial Y-BOCS scores. Factors associated with a bad outcome were higher age at assessment, a longer duration of psychiatric inpatient treatment before assessment and a low level of social functioning (BSS). For LOCD patients living in a stable relationship, high motivation and completing treatment predicted a favourable therapy outcome, while a low level of psychological functioning (BSS) and a longer duration of inpatient psychiatric treatment before assessment were associated with an undesirable therapy outcome. Conclusions: Subtyping OCD patients according to age of onset seems to be a promising avenue towards improving and developing more specified treatment programs.