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Donor insemination (DI) has undergone radical changes in the last 25 years, for example exclusive use of frozen semen, and increasing use of DI for single women. A summary of these is presented as are the potential challenges we still face. The latter include key questions such as what are the key methods for optimising treatment. Can we improve our success rates? If so, how can this be done? Moreover, the use of DI as a research tool, often ignored, is presented.
This revised and updated second edition provides a comprehensive account of the human male gamete. Detailed overviews of human sperm production, maturation, and function - and how these processes affect and influence fertility, infertility, and assisted reproduction - are given. A wide range of new developments including proteomics, spermatogenesis, sperm-specific WW domain-binding proteins, Ca2+ signalling, DNA packaging, epididymis are explored, whilst a new chapter presents information gained from mouse genetics, highlighting how it informs male fertility research. The impact of environmental factors during pre-pubertal and pubertal stages of life is also investigated. Featuring engaging prose with chapters organized topographically, The Sperm Cell remains an essential resource for andrologists, clinical scientists, and laboratory personnel.
Chronic anovulation is an important cause of infertility, accounting for approximately 20% of all causes. Men should have had a semen analysis and women should have had the basic infertility work-up including an assessment of tubal patency. In 1973 the World Health Organization published a simple classification of anovulation, namely, WHO I, II and III. WHO I patients are characterized by a history of amenorrhea. WHO II is characterized by a history of oligomenorrhea, although there may be some with amenorrhea. Central obesity is a cardinal feature of women with polycystic ovary syndrome (PCOS) with an increased waist-hip ratio. WHO III is characterized by oligoamenorrhea, and may present with menopausal symptoms, such as hot flushes, night sweats, and vaginal dryness. This chapter presents the treatment for WHO I, II, and III patients. The treatment involves lifestyle modification, aromatase inhibitors, insulin-sensitizing drugs, and hyperprolactinemia.
This practical, extensively illustrated handbook covers the procedures that are undertaken in andrology and ART laboratories to analyse and assess male-factor infertility, and to prepare spermatozoa for use in assisted conception therapy. The content is presented as brief, authoritative overviews of the relevant biological background for each area, plus detailed, step-by-step descriptions of the relevant analytical procedures. Each technical section includes pertinent quality control considerations, as well as the optimum presentation of results. In addition to the comprehensive 'basic' semen analysis, incorporating careful analysis of sperm morphology, the handbook provides established techniques for the use of computer-aided sperm analysis and sperm functional assessment. Throughout the handbook the interpretation of laboratory results in the clinical context is highlighted, and safe laboratory practice is emphasized. It is an invaluable resource to all scientists and technicians who perform diagnostic testing for male-factor infertility.