To meet rising customer requirements, increasingly complex products have to be virtually validated. To achieve this within the framework of virtual product development, a wide range of aspects has to be taken into account. In this context, tolerance analysis has established itself as a proven tool to evaluate the consequences of geometric part deviations on geometric product characteristics. Existing approaches, however, do not sufficiently take into account production-specific deviations, leading to time-consuming iterations during the product development process. Therefore, the focus of this contribution is on process-oriented interdisciplinary tolerance management that allows the integration of manufacturing simulations into the tolerance analysis. In contrast to the conventional approach, this novel methodology allows to avoid unnecessary iterations in the context of product development and validation. Following the presentation of the novel procedure, the application on a case study of an X- ray shutter is carried out, whereby surrogate models are integrated in order to reduce the computing time.