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A key objective for upcoming surveys, and when re-analysing archival data, is the identification of variable stellar sources. However, the selection of these sources is often complicated by the unavailability of light curve data. Utilising a self-organising map (SOM), we demonstrate the selection of diverse variable source types from a catalogue of variable and non-variable SDSS Stripe 82 sources whilst employing only the median $u-g$, $g-r$, $r-i$, and $i-z$ photometric colours for each source as input, without using source magnitudes. This includes the separation of main sequence variable stars that are otherwise degenerate with non-variable sources ($u-g$,$g-r$) and ($r-i$,$i-z$) colour-spaces. We separate variable sources on the main sequence from all other variable and non-variable sources with a purity of $80.0\%$ and completeness of $25.1\%$, figures which can be modified depending on the application. We also explore the varying ability of the same method to simultaneously select other types of variable sources from the heterogeneous sample, including variable quasars and RR-Lyrae stars. The demonstrated ability of this method to select variable main sequence stars in colour-space holds promise for application in future survey reduction pipelines and for the analysis of archival data, where light curves may not be available or may be prohibitively expensive to obtain.
Caregivers can play an important role in supporting and caring for people with progressive, life-threatening, or debilitating conditions. However, this supportive role can expose caregivers to various detrimental financial, physical, and psychosocial issues. When evaluating medical technologies for reimbursement decisions, health technology assessment (HTA) agencies typically focus on the treatment’s impact on patients and ignore or downplay the impact on caregivers. Including caregiver impacts within a wider societal perspective may better enable health systems to maximize health benefits from available resources. However, the lack of clear guidance or methodological recommendations from decision makers on the inclusion of caregiver impacts limits the number of HTA submissions that consider these effects. We outline a conceptual framework based on intensity and duration of caregiving to guide researchers, industry, and decision makers when developing policies for the inclusion of caregiver outcomes and justify their inclusion based on expected caregiver burden in identified circumstances.
Infrared (Visible-Near Infrared-Shortwave Infrared (VNIR-SWIR)) spectroscopy is a cost-effective technique for mineral identification in the field. Modern hand-held spectrometers are equipped with on-board spectral libraries that enable rapid, qualitative analysis of most minerals and facilitate recognition of key alteration minerals for exploration. Spectral libraries can be general or customized for specific mineral deposit environments. To this end, careful collection of spectra in a controlled environment on pure specimens of key minerals was completed using the National Mineral Reference Collection (NMC) of the Geological Survey of Canada. The spectra collected from specimens in the ‘Kodama Clay Collection’ were processed using spectral plotting software and each new example was validated before being added to a group of spectra considered for incorporation into the on-board library of the handheld ASD-TerraSpec Halo near-infrared (NIR) mineral identification instrument. Spectra from an additional suite of mineral samples of the NMC containing REE, U, Th, and/or Nb are being prepared for a new, publicly available spectral library. These minerals commonly occur in carbonatite or alkali intrusive deposits, and as such will assist in the exploration for critical metals.
Rapid antigen detection tests (Ag-RDT) for SARS-CoV-2 with emergency use authorization generally include a condition of authorization to evaluate the test’s performance in asymptomatic individuals when used serially. We aim to describe a novel study design that was used to generate regulatory-quality data to evaluate the serial use of Ag-RDT in detecting SARS-CoV-2 virus among asymptomatic individuals.
Methods:
This prospective cohort study used a siteless, digital approach to assess longitudinal performance of Ag-RDT. Individuals over 2 years old from across the USA with no reported COVID-19 symptoms in the 14 days prior to study enrollment were eligible to enroll in this study. Participants throughout the mainland USA were enrolled through a digital platform between October 18, 2021 and February 15, 2022. Participants were asked to test using Ag-RDT and molecular comparators every 48 hours for 15 days. Enrollment demographics, geographic distribution, and SARS-CoV-2 infection rates are reported.
Key Results:
A total of 7361 participants enrolled in the study, and 492 participants tested positive for SARS-CoV-2, including 154 who were asymptomatic and tested negative to start the study. This exceeded the initial enrollment goals of 60 positive participants. We enrolled participants from 44 US states, and geographic distribution of participants shifted in accordance with the changing COVID-19 prevalence nationwide.
Conclusions:
The digital site-less approach employed in the “Test Us At Home” study enabled rapid, efficient, and rigorous evaluation of rapid diagnostics for COVID-19 and can be adapted across research disciplines to optimize study enrollment and accessibility.
To identify which international health technology assessment (HTA) agencies are undertaking evaluations of medical tests, summarize commonalities and differences in methodological approach, and highlight examples of good practice.
Methods
A methodological review incorporating: systematic identification of HTA guidance documents mentioning evaluation of tests; identification of key contributing organizations and abstraction of approaches to all essential HTA steps; summary of similarities and differences between organizations; and identification of important emergent themes which define the current state of the art and frontiers where further development is needed.
Results
Seven key organizations were identified from 216 screened. The main themes were: elucidation of claims of test benefits; attitude to direct and indirect evidence of clinical effectiveness (including evidence linkage); searching; quality assessment; and health economic evaluation. With the exception of dealing with test accuracy data, approaches were largely based on general approaches to HTA with few test-specific modifications. Elucidation of test claims and attitude to direct and indirect evidence are where we identified the biggest dissimilarities in approach.
Conclusions
There is consensus on some aspects of HTA of tests, such as dealing with test accuracy, and examples of good practice which HTA organizations new to test evaluation can emulate. The focus on test accuracy contrasts with universal acknowledgment that it is not a sufficient evidence base for test evaluation. There are frontiers where methodological development is urgently required, notably integrating direct and indirect evidence and standardizing approaches to evidence linkage.
The race to develop and implement autonomous systems and artificial intelligence has challenged the responsiveness of governments in many areas and none more so than in the domain of labour market policy. This article draws upon a large survey of Singaporean employees and managers (N = 332) conducted in 2019 to examine the extent and ways in which artificial intelligence and autonomous technologies have begun impacting workplaces in Singapore. Our conclusions reiterate the need for government intervention to facilitate broad-based participation in the productivity benefits of fourth industrial revolution technologies while also offering re-designed social safety nets and employment protections.
This discussion paper by a group of scholars across the fields of health, economics and labour relations argues that COVID-19 is an unprecedented humanitarian crisis from which there can be no return to the ‘old normal’. The pandemic’s disastrous worldwide health impacts have been exacerbated by, and have compounded, the unsustainability of economic globalisation based on the neoliberal dismantling of state capabilities in favour of markets. Flow-on economic impacts have simultaneously created major supply and demand disruptions, and highlighted the growing within-country inequalities and precarity generated by neoliberal regimes of labour market regulation. Taking an Australian and international perspective, we examine these economic and labour market impacts, paying particular attention to differential impacts on First Nations people, developing countries, women, immigrants and young people. Evaluating policy responses in a political climate of national and international leadership very different from those in which major twentieth century crises were addressed, we argue the need for a national and international conversation to develop a new pathway out of crisis.
This chapter explores the regulatory regimes that may be applied to data science. They could be legally mandated, established by voluntary trade groups, or established for business rationale (e.g., to minimize insurance costs). Perhaps, growing societal norms will become de facto standards. The authors focus on just a few topics and refer the reader to a vast and growing literature on regulation coming from public policy, economic, technology, and legal perspectives.
This chapter summarizes societal concerns surrounding data and automation. It is informed not only by what is being discussed by politicians and journalists, but also by the challenges discussed in previous chapters. Examples include societal concerns over data science’s impact on inequality, the scale of large, data-science-oriented companies and the influence of social networks.
This chapter makes two R&D recommendations to address concerns raised in Chapter 15: increasing focused and transdisciplinary research; and fostering innovation.
This chapter discusses the importance of education and rigor in the definition and use of vocabulary surrounding automation and data. More education helps individuals by enhancing their ability to understand data and data science’s growing impact, and to both contribute to and benefit from the field. A more knowledgeable public and a clear vocabulary for discourse is needed to have better communication and debate.
This chapter addresses the four aspects of dependability: privacy, security, resistance to abuse, and resilience. To be accepted by society, data science applications must perform properly for a wide variety of users in a wide variety of circumstances, with few, if any, critical errors. Achieving needed dependability goals (for example, in self-driving cars or health-care applications) is one of the greatest challenges in data science.