We investigate experimentally and theoretically the interactions between a cavitation bubble and a hemispherical pendant oil droplet immersed in water. In experiments, the cavitation bubble is generated by a focused laser pulse right below the pendant droplet with well-controlled bubble–wall distances and bubble–droplet size ratios. By high-speed imaging, four typical interactions are observed, namely: oil droplet rupture; water droplet entrapment; oil droplet large deformation; and oil droplet mild deformation. The bubble jetting at the end of collapse and the migration of the bubble centroid are particularly different in each bubble–droplet interaction. We propose theoretical models based on the method of images for calculating the Kelvin impulse and the anisotropy parameter which quantitatively reflects the migration of the bubble centroid at the end of the collapse. Finally, we explain that a combination of the Weber number and the anisotropy parameter determines the regimes of the bubble–droplet interactions.

Interactions between oblique second mode and oblique waves at a high-speed boundary at Mach 4.5 are studied using linear stability theory, nonlinear parabolized stability equations (NPSE) and direct numerical simulation (DNS). Parametric analysis based on the NPSE suggests that the oblique second mode can amplify both the oblique first and second modes, with the former experiencing a higher amplification. Our analysis reveals that the mean-flow distortion and difference mode contribute to this enhancement, with the latter exerting a key influence through the parametric resonance process. Kinetic energy transfer analysis demonstrates that the oblique waves gain energy from the mean flow, rather than from the oblique second mode. Furthermore, we find that the mechanism underlying the interaction between a pair of second oblique waves and a single oblique wave is similar to that between an oblique second mode and an oblique wave, as the steady modes generated by the pair of oblique second modes have a limited impact on the oblique wave. Finally, DNS confirms the validity of two transition paths proposed in this study based on the NPSE results. The first path suggests that a pair of low-amplitude second oblique waves alone are insufficient to cause oblique breakdown, but the introduction of a pair of low-amplitude damping first oblique modes could lead to boundary layer breakdown. The second path involves the formation of a domino-like effect through the combination of different types of oblique waves with the appropriate parameters. These two nonlinear paths can lead to a fully developed turbulent boundary layer.

Fitouchi et al. illustrate the cognitive and evolutionary foundations of puritanical morality, while leave the emotional foundation unclear. We complement their theory by proposing moral emotions (e.g., guilt and shame) as characteristic emotions underlying puritanical morality. Our proposition is based on the findings that these moral emotions emerge after violations of puritanical norms and promote self-control and cooperation.

Purple nutsedge (Cyperus rotundus L.) is a globally distributed noxious weed that poses a significant challenge for control due to its fast and efficient propagation through the tuber, which is the primary reproductive organ. Gibberellic acid (GA3) has proven to be crucial for tuberization in tuberous plants. Therefore, understanding the relationship between GA3 and tuber development and propagation of C. rotundus will provide valuable information for controlling this weed. This study shows that the GA3 content decreases with tuber development, which corresponds to lower expression of bioactive GA3 synthesis genes (CrGA20ox, two CrGA3ox genes) and two upregulated GA3 catabolism genes (CrGA2ox genes), indicating that GA3 is involved in tuber development. Simultaneously, the expression of two CrDELLA genes and CrGID1 declines with tuber growth and decreased GA3, and yeast two-hybrid assays confirm that the GA3 signaling is DELLA-dependent. Furthermore, exogenous application of GA3 markedly reduces the number and the width of tubers and represses the growth of the tuber chain, further confirming the negative impact that GA3 has on tuber development and propagation. Taken together, these results demonstrate that GA3 is involved in tuber development and regulated by the DELLA-dependent pathway in C. rotundus and plays a negative role in tuber development and propagation.

Hypersonic flow on a V-shaped blunt leading edge (VSBLE) at Mach 12 is numerically investigated. A series of self-induced shock–shock interactions and shock wave/boundary layer interactions (SWBLIs) cause extremely high heat flux peaks on the crotch of the VSBLE. Based on these shock structures, a simplified model that divides the flow field into inviscid and viscous areas is constructed. This model can quickly solve the shock interactions and predict the heating/pressure peaks with high accuracy. Furthermore, a shock control bump (SCB) is placed on the SWBLI region to split the strong incident shock into a weaker multi-wave system. The mechanism study of the SCB shows that the inviscid effect significantly reduces the heating/pressure peaks, and the viscous effect suppresses the SWBLI-induced separation. Finally, a VSBLE with SCBs is numerically investigated. The heat flux peak is reduced by 66 % compared to that without the SCBs. The robustness of the SCB under various working conditions is also evaluated. This paper provides an idea for the simplified solution of complex shock interactions and extends the application of the SCB as a thermal protection device in hypersonic flow for the first time.

The development of high-brightness X-ray free electron lasers (XFELs), such as hard X-ray self-seeding free electron lasers and XFEL oscillators (XFELOs), brings a severe challenge to the crystal monochromator due to a strong non-uniform thermal load. The distortion caused by spatial temperature gradients can severely affect the optical performance of crystals. Therefore, this paper presents a model to estimate the performance of non-uniform thermally distorted crystals. The model not only takes into account thermal strain, slope error and incident angle deviation, but also considers temperature-dependent factors such as the Debye–Waller factor and electric susceptibility. Our investigation indicates that the Debye–Waller factor reduces the height and bandwidth of rocking curves, and the impact of the electric susceptibility is tiny. The proposed model can describe the distortion of the reflectivity and transmissivity curves of non-uniform thermally loaded crystals and can be applied in the design of crystal monochromators, crystal splitters, crystal compressors and XFELOs.

We perform a two-dimensional numerical study on the thermal effect of porous media on global heat transport and flow structure in Rayleigh–Bénard (RB) convection, focusing on the role of thermal conductivity $\lambda$ of porous media, which ranges from $0.1$ to $50$ relative to the fluid. The simulation is carried out in a square RB cell with the Rayleigh number $Ra$ ranging from $10^7$ to $10^9$ and the Prandtl number $Pr$ fixed at $4.3$. The porosity of the system is fixed at $\phi =0.812$, with the porous media modelled by a set of randomly displayed circular obstacles. For a fixed $Ra$, the increase of conductivity shows a small effect on the total heat transfer, slightly depressing the Nusselt number. The limited influence comes from the small number of obstacles contacting with thermal plumes in the system as well as the counteraction of the increased plume area and the depressed plume strength. The study shows that the global heat transfer is insensitive to the conduction effect of separated porous media in the bulk region, which may have implications for industrial designs.

The Viséan–Serpukhovian boundary is poorly defined in South China, hampering regional and global stratigraphical correlations. The foraminiferal and conodont distribution of the Baping Formation in the carbonate-slope Danlu section permits the recognition of an interval from the middle Viséan to the uppermost Serpukhovian in a continuous succession. The base of the Serpukhovian in Danlu is recognized by the first occurrences of Janischewskina delicata, Howchinia subplana and questionable ‘Millerella’ tortula. At a slightly younger level, the conodont Lochriea ziegleri is first recorded. A calibration on the first occurrence of L. ziegleri in different basins at a global scale has been revised compared to auxiliary markers within the ammonoids and foraminifers. The late occurrence of L. ziegleri in the Danlu section also supports a lack of synchronicity in the global first occurrence of this taxon. This study calls for the recognition of a new base for the Serpukhovian under a far better correlation between different zonal schemes and fossil groups.

A novel curved surface nanowire target is proposed to improve the cutoff energy of accelerated protons via target normal sheath acceleration. The interaction of a laser of intensity $1.37\times 10^{20}\ {\rm W}\ {\rm cm}^{-2}$ with a curved surface nanowire target is studied by two-dimensional particle-in-cell simulations. The numerical results indicate that the sheath electric field at the target rear side is significantly enhanced by this simple target design, compared with using the planar nanowire target. The transverse motion of hot electrons is effectively confined and the energy density of electrons is naturally increased. A series of simulations with various target parameters is carried out to investigate the performance of this novel target. This tailored target may provide implications for generating high-quality proton beams in experiments.

Fat deposition and lipid metabolism are closely related to the morphology, structure and function of mitochondria. The morphology of mitochondria between fusion and fission processes is mainly regulated by protein posttranslational modification. Intermittent fasting (IF) promotes high expression of Sirtuin 3 (Sirt3) and induces mitochondrial fusion in high-fat diet (HFD)-fed mice. However, the mechanism by which Sirt3 participates in mitochondrial protein acetylation during IF to regulate mitochondrial fusion and fission dynamics remains unclear. This article demonstrates that IF promotes mitochondrial fusion and improves mitochondrial function in HFD mouse inguinal white adipose tissue. Proteomic sequencing revealed that IF increased protein deacetylation levels in HFD mice and significantly increased Sirt3 mRNA and protein expression. After transfecting with Sirt3 overexpression or interference vectors into adipocytes, we found that Sirt3 promoted adipocyte mitochondrial fusion and improved mitochondrial function. Furthermore, Sirt3 regulates the JNK-FIS1 pathway by deacetylating malate dehydrogenase 2 (MDH2) to promote mitochondrial fusion. In summary, our study indicates that IF promotes mitochondrial fusion and improves mitochondrial function by upregulating the high expression of Sirt3 in HFD mice, promoting deacetylation of MDH2 and inhibiting the JNK-FIS1 pathway. This research provides theoretical support for studies related to energy limitation and animal lipid metabolism.

We firstly report a 2-μm all-fiber nonlinear pulse compressor based on two pieces of normal dispersion fiber (NDF), which enables a high-power scaling ability of watt-level and a high pulse compression ratio of 13.7. With the NDF-based all-fiber nonlinear pulse compressor, the 450-fs laser pulses with a repetition rate of 101.4 MHz are compressed to 35.1 fs, corresponding to a 5.2 optical oscillation cycle at the 2-μm wavelength region. The output average power reaches 1.28 W, which is believed to be the highest value never achieved from the previous 2-μm all-fiber nonlinear pulse compressors with a high pulse repetition rate above 100 MHz. The dynamic evolution of the ultrafast pulse inside the all-fiber nonlinear pulse compressor is numerically analyzed, matching well with the experimental results.

In 2016, an outbreak of paratyphoid fever occurred in 40 cases at Qingyang town, in China. A case-control study was carried out to determine the source of this outbreak. Case-control study was conducted to identify the risk factors of this outbreak. The cases were identified as patients with isolation of S. Paratyphi, controls were confirmed cases’ healthy classmates, colleagues or neighbors and matched by age (±5 y) and gender. Pulsed-field gel electrophoresis was performed to source tracking. Totally, 40 cases were reported: 24 cases were students, and 20 (20/24) of them were Qingyang High School students. For the case-control study, consuming Chinese egg pancakes was detected as a risk factor (OR1:1 = 5.000; 95% CI: 1.710-14.640), and hand-washing before meals was protective behavior compared with seldom hand-washing (OR1:1 = 23.256; 95% CI: 2.451-200.000). S. Paratyphi was cultured from a well water sample used for washing contents of the pancakes. Isolates from well water and paratyphoid cases showed the same PFGE patterns. Contaminated well water and Chinese egg pancakes were likely source and vehicle of this outbreak. Health education, especially handwashing, and food safety supervision should be promoted particularly in schools.

Oblique breakdown in a Mach 2.0 supersonic boundary layer controlled by a local cooling strip with a temperature jump is investigated using direct numerical simulations and linear stability theory. The effect of temperature on the stability of the fundamental oblique waves is first studied by linear stability theory. It is shown that the growth rate of fundamental oblique waves will decrease monotonically as the temperature decreases. However, the results of the direct numerical simulations indicate that transition reversal will occur as the growth rate of the fundamental oblique waves of cooled case becomes faster compared with that of baseline case downstream of the cooling strip. When the cooling strip is in the linear region, the transition is delayed due to the suppression effect of the cooling strip on the fundamental oblique waves. When the cooling strip is located in the early nonlinear region, the fundamental oblique waves will be suppressed by higher spanwise wavenumber steady modes generated by the mutual and self-interaction between the fundamental oblique waves and harmonic modes, which is first called the self-suppression effect (SSE) in the present study. Further research indicated that the meanflow distortion generated by steady modes plays an important role in the SSE. Compared with the stabilization effect of the cooling strip, the SSE is more effective. Moreover, the SSE might provide a new idea on the instability control, as it is observed that the SSE works three times leading to the growth rate of fundamental oblique waves slowing down at three different regions, respectively.

The wind energy industry relies on computationally efficient engineering-type models to design wind farms. Typically these models do not account for the effect of atmospheric stratification in either the boundary layer or the free atmosphere. This study proposes a new analytical model for fully developed wind-turbine arrays in conventionally neutral atmospheric boundary layers frequently encountered in nature. The model captures the effect of the free-atmosphere stratification, Coriolis force, wind farm layout and turbine operating condition on the wind farm performance. The model is developed based on the physical insight derived from large-eddy simulations. We demonstrate that the geostrophic drag law (GDL) for flow over flat terrain can be extended to flow over fully developed wind farm arrays. The presence of a vast wind farm significantly increases the wind farm friction velocity compared with flow over flat terrain, which is modelled by updated coefficients in the GDL. The developed model reliably captures the vertical wind speed profile inside the wind farm. Furthermore, the power production trends observed in simulations are reliably reproduced. The wind farm performance, normalized by the geostrophic wind speed, decreases as the free-atmosphere thermal stability increases or the Coriolis force decreases. In addition, we find that the optimal wind farm performance is obtained at a lower thrust coefficient than the Betz limit, which indicates that optimal operating conditions for turbines in a wind farm are different than for a single turbine.

Mechanistic studies have suggested that antioxidants have beneficial effects on age-related macular degeneration (AMD). This study aimed to investigate the association between the types and sources of dietary vitamin and carotenoid intakes and AMD risk in China. A matched case–control study of 260 AMD cases and 260 matched controls was performed. The participants were interviewed for dietary information and potential confounders, and comprehensive ophthalmic examinations were performed. Conditional logistic models were used to estimate the odds ratio (OR) and 95 % confidence interval (CI) of specific vitamins and carotenoids and their main sources. When comparing the extreme quartiles, the ORs (95 % CI) were 0·30 (0·10, 0·88) for lutein and 0·28 (0·11, 0·74) for β-cryptoxanthin. The associations for other dietary vitamin and carotenoid intakes were generally weaker and non-significant. Higher intakes of spinach and egg, which are important sources of lutein, were associated with a reduced odds of AMD. ORs (95% CIs) comparing extreme categories were 0·42 (0·20, 0·88) for spinach and 0·52 (95% CI: 0·27, 0·98) for egg. Participants who were in the highest category of both egg intake and spinach intake had a much greater reduced odds of having AMD (OR: 0·23; 95% CI: 0·08, 0·71) than those in the lowest category of egg intake and spinach intake. In conclusion, a higher intake of lutein and lutein-rich foods was associated with a significantly decreased odds of AMD. These findings provide further evidence of the benefits of lutein and lutein-rich foods in the prevention of AMD.

Blood oxygen is an essential component for numerous biological processes of mammalian animals. Milk production of ruminants largely relies on the supply of nutrients, such as glucose, amino acids and fatty acids. To define the regulatory role of blood oxygen availability in regard to milk production, seventy-five healthy Guanzhong dairy goats with similar body weight, days in milk and parities were selected. For each animal, milk yield was recorded and milk sample was collected to determine compositions. Milk vein blood was collected to determine parameters including blood gas, physio-biochemistry and haematology. Another blood sample was prepared for transcriptome and RT-qPCR. Results showed that both pressure of oxygen (pO2) in the milk vein (positively) and numbers of neutrophils in mammary vein (negatively) were associated with milk yield of the animals. To learn the role of pO2 in blood cell functionality, twelve animals (six with higher yield (H-group) and six with lower yield (L-group)) from seventy-five goats were selected. Compared with animals in L-group, goats in H-group were higher in pO2 but lower in pCO2, lactate, lactate dehydrogenase activity and neutrophil abundance in milk vein, compared with L-group. The blood transcriptome analysis suggested that compared with L-group, animals in H-group were depressed in functionality including neutrophil activation and metabolic pathways including glycolysis, NF-κB and HIF-1. Our result revealed that lower milk production could be associated with neutrophil activation responding to low pO2 in the mammary vein. In the meantime, we highlighted the potential importance of blood oxygen as a milk yield regulator.

We study the translational and rotational dynamics of neutrally buoyant finite-size spheroids in hydrodynamic turbulence by means of fully resolved numerical simulations. We examine axisymmetric shapes, from oblate to prolate, and the particle volume dependences. We show that the accelerations and rotations experienced by non-spherical inertial-scale particles result from volume filtered fluid forces and torques, similar to spherical particles. However, the particle orientations carry signatures of preferential alignments with the surrounding flow structures, which are reflected in distinct axial and lateral fluctuations for accelerations and rotation rates. The randomization of orientations does not occur even for particles with volume-equivalent diameter size in the inertial range, here up to $60$ dissipative units ($\eta$) at Taylor-scale Reynolds number ${Re_{\lambda }=120}$. Additionally, we demonstrate that the role of fluid boundary layers around the particles cannot be neglected in reaching a quantitative understanding of particle statistical dynamics, as they affect the intensities of the angular velocities and the relative importance of tumbling with respect to spinning rotations. This study brings to the fore the importance of inertial-scale flow structures in homogeneous and isotropic turbulence and their impacts on the transport of neutrally buoyant bodies with sizes in the inertial range.