To send content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about sending content to .
To send content items to your Kindle, first ensure email@example.com
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about sending to your Kindle.
Note you can select to send to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
Circular string matching is a problem which naturally arises in many contexts. It consists in finding all occurrences of the rotations of a pattern of length m in a text of length n. There exist optimal worst- and average-case algorithms for circular string matching. Here, we present a suboptimal average-case algorithm for circular string matching requiring time
(n) and space
(m). The importance of our contribution is underlined by the fact that the proposed algorithm can be easily adapted to deal with circular dictionary matching. In particular, we show how the circular dictionary-matching problem can be solved in average-case time
(n + M) and space
(M), where M is the total length of the dictionary patterns, assuming that the shortest pattern is sufficiently long. Moreover, the presented average-case algorithms and other worst-case approaches were also implemented. Experimental results, using real and synthetic data, demonstrate that the implementation of the presented algorithms can accelerate the computations by more than a factor of two compared to the corresponding implementation of other approaches.
Messenger RNA (mRNA) is the key intermediate in the gene expression pathway. The amount of mRNA in Alzheimer's disease (AD) brains has been determined using in situ hybridization histochemistry (ISHH) to detect the poly(A) tails of polyadenylated mRNA (poly(A) + mRNA). On a regional basis, AD cases had significantly less poly(A) + mRNA than controls in hippocampus (field CA3) and cerebellum (granule cell layer). Analysis of constituent pyramidal neurons showed mean reductions per cell within AD hippocampus (field CA3) and temporal cortex, but not in visual cortex. Similar changes were seen in a small group of non-AD dementias. The finding of reduced poly(A) + mRNA content is another indication of the altered brain gene expression occurring in AD. It is proposed that measurement of poly(A) + mRNA may be valuable in identifying functionally impaired neuronal populations. The methodology also provides a means by which changes in the quantitative distribution of individual mRNAs can be determined relative to that of poly(A) + mRNA as a whole.
Email your librarian or administrator to recommend adding this to your organisation's collection.