To send content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about sending content to .
To send content items to your Kindle, first ensure firstname.lastname@example.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about sending to your Kindle.
Note you can select to send to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
Background: Migraine is a prevalent and disabling condition with limited understanding in the developing brain. Adults with chronic migraine show structural alterations in pain and sensory processing regions. Similar data is lacking in children and required for early intervention. Methods: Case-control feasibility study assessing structural brain differences between adolescents with chronic migraine and healthy controls using 3T Siemens structural volumetric MRI analysis. Fifteen subjects with chronic migraine were compared to 25 age and sex matched healthy controls. Non-parametric statistics performed (Kruskal-Wallis). Results: Migraine subjects had reduced volumes in total brain (grey and white matter) (KW p <0.03), total thalamus (KW p <0.01) and hippocampal regions (KW p <0.03). Unilateral (right) cerebellar grey matter volumes were significantly reduced in migraine subjects versus controls (KW p<0.05). No significant differences were found in other regions, including basal ganglia, cortical grey matter and brainstem. Conclusions: Total brain, hippocampal and thalamic volumetric reductions are seen in adolescents with chronic migraine. The regions identified are involved in migraine pathogenesis. This volumetric imaging study should improve understanding of the causes and effects of pediatric migraine.
Introduction: In the province of Québec, roughly 20% of the population lives in rural areas. Rural emergency departments (EDs) face different challenges than their urban counterparts. Yet, few studies have sought to understand these challenges. This study aims to survey Québec’s emergency physicians to: 1) identify problems specific to rural EDs, 2) find solutions for improving accessibility and quality of care offered in rural regions and, 3) rank solutions in order of priority. These results will allow data triangulation with other of our studies that seek to identify challenges faced by rural EDs and potential solutions. Methods: During the 2016 annual conference of the Québec Emergency Physicians’ Association, we asked physicians and residents (including those from urban EDs), to complete a survey about the challenges faced by rural EDs. The survey contained two sections. The first took the form of open-ended questions in which respondents could write three challenges about accessibility and quality of care in rural EDs (objective 1) and three solutions to address these challenges (objective 2). The second section listed 11 potential solutions identified in our previous study. The solutions were ranked based on their priority level on a five-point Likert scale that ranged from “not a priority” to “an absolute priority” (objective 3). We added the total number of points for each solution and produced a ranking list. Results: Ninety-one physicians out of the 417 at the conference completed the survey; 58% came from urban EDs and 42% from rural EDs. Open-ended questions suggest that access to specialists and interfacility transfers are the principal challenges faced by rural EDs. The top five solutions identified as the highest priorities were: 1) care protocols, 2) improvement of interfacility transfers, 3) training with simulators, 4) targeted ultrasound and, 5) implementation of staff retention and recruitment strategies. Conclusion: This study is relevant and useful as roughly a quarter of attendants at the conference spontaneously volunteered to help identify and prioritize solutions to foster the accessibility and quality of care in rural EDs. Furthermore, it represents a stepping stone for our recently-launched wide-scope study, Urgences Rurales 360, that aims to explore problems faced by every of the 28 rural EDs in Québec and the solutions that could be implemented to resolve them.
This triennial report (1996-1999) reviews the subject from a somewhat personal angle, mostly related to binary star formation and young binary star populations – a subject whose time had come in the early 1990s and is now in full swing.
Many astronomers have searched for binary systems among main-sequence stars, and two large-scale surveys published in 1991 and 1992 have already become classics. Well before they became famous for finding extrasolar planets (see below), observing teams led by Michel Mayor (Geneva Observatory) and Geoffrey Marcy (San Francisco State Univ., now Univ. of Calif, at Berkeley) spent many years searching for low-mass stellar companions of nearby stars. The late Antoine Duquennoy and Mayor surveyed all solar-type dwarfs (spectral types F7 through G9) within 20 pc of the Sun, while Debra Fischer and Marcy studied stars with somewhat lower mass (M dwarfs) slightly nearer to the Sun.
The objective of the Apollon project is the generation of 10 PW peak power pulses of 15 fs at 1 shot/minute. In this paper the Apollon facility design, the technological challenges and the current progress of the project will be presented.
In 2011 the IRSN conducted several assessments of atmospheric
radioactive releases due to the Fukushima Daiichi NPP accident (March
11, 2011) and of their impact on Japan’s terrestrial environment.
They were based on the IRSN’s emergency management tools and on
the abundant information and technical data gradually published
in Japan. According to these assessments, the main release phase
lasted from March 12 to 25, 2011 and impacted Japanese land in two
events, the first on 15 and 16 March, in which the main radioactive
deposits were formed, and the second from March 20 to 23, which
was less significant. The highest amounts of radioactive deposits were
found in an area extending upwards of several tens of kilometers
northwest of the plant. Lower amounts were discontinuously scattered
in an area extending up to over 250 km away. Initially composed
mainly of short-lived radionuclides, the deposits’ activity sharply
decreased in the subsequent weeks. Since the summer of 2011, cesium-134
and cesium-137 have become the residual deposits’ main components.
According to IRSN estimates, in the absence of protection, the doses
due to exposure to the radioactive plume during the atmospheric
release phase may have been potentially higher for people who remained
in coastal areas up to several tens of kilometers north and south
of the damaged plant. Thereafter, people living up to 50 km northwest
of the plant, outside the 20-km emergency evacuation zone, were potentially
most vulnerable to residual radioactive deposits over time.
The growing number of spastic ataxia of Charlevoix-Saguenay (SACS) gene mutations reported worldwide has broadened the clinical phenotype of autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS). The identification of Quebec ARSACS cases without two known SACS mutation led to the development of a multi-modal genomic strategy to uncover mutations in this large gene and explore phenotype variability.
Search for SACS mutations by combining various methods on 20 cases with a classical French-Canadian ARSACS phenotype without two mutations and a group of 104 sporadic or recessive spastic ataxia cases of unknown cause. Western blot on lymphoblast protein from cases with different genotypes was probed to establish if they still expressed sacsin.
A total of 12 mutations, including 7 novels, were uncovered in Quebec ARSACS cases. The screening of 104 spastic ataxia cases of unknown cause for 98 SACS mutations did not uncover carriers of two mutations. Compounds heterozygotes for one missense SACS mutation were found to minimally express sacsin.
The large number of SACS mutations present even in Quebec suggests that the size of the gene alone may explain the great genotypic diversity. This study does not support an expanding ARSACS phenotype in the French-Canadian population. Most mutations lead to loss of function, though phenotypic variability in other populations may reflect partial loss of function with preservation of some sacsin expression. Our results also highlight the challenge of SACS mutation screening and the necessity to develop new generation sequencing methods to ensure low cost complete gene sequencing.
This paper describes first steps in preparation of an organic spin valve based on a perylene derivative (PTCTE) sandwiched between magnetite (Fe3O4) and cobalt (Co) ferromagnetic electrodes. MgO(001)/Fe3O4/PTCTE (450 nm)/Co devices were prepared with different Co soft deposition methods: off-axis dc-sputtering or Joule evaporation. Vibrating Sample Magnetometer (VSM) studies of the Fe3O4/PTCTE/Co stacks evidence spin valve behavior with magnetically uncoupled electrodes. These results are correlated with a morphological study by atomic force microscopy (AFM) of each layer and tunneling AFM (TUNA) for the investigation of inhomogeneity of current distribution in the devices. Finally, macroscopic I-V characteristics performed on the same devices will be presented and compared with TUNA results.
This paper presents the evaluation of oxidizing and reducing plasmas for post etch pore-sealing treatments during patterning of interconnections in a porous Ultra Low-k (ULK) material. Morphological and chemical characterizations as well as electrical results (resistance, capacitance, leakage, yield) are presented for both single and dual-damascene integrations.
A technology platform is described for the integration of low-loss inductors, capacitors, and MEMS capacitors on a high-resistivity Si substrate. Using this platform the board space area taken up by e.g. a DCS PA output impedance matching circuit can be reduced by 50%. The losses of passive components that are induced by the semi-conducting Si substrate can effectively be suppressed using a combination of surface amorphisation and the use of poly crystalline Si substrates. A MEM switchable capacitor with a capacitance switching factor of 40 and an actuation voltage of 5V is demonstrated. A continuous tuneable dual-gap capacitor is demonstrated with a tuning ratio of 9 using actuation voltages below 15V.
We present a detailed dynamical study of the old (7 Gyr) open cluster NGC 188. Our combined radial-velocity data set spans a baseline of 35 years, a magnitude range of 12 ≤ V ≤ 16.5, and a 1° diameter region on the sky. Our magnitude limits include solar-mass main-sequence stars, subgiants, giants, and blue stragglers, and our spatial coverage extends radially to 11.5 core radii. We have measured radial velocities for 1014 stars in the direction of NGC 188 with a precision of 0.4 km s−1, and have calculated radial-velocity membership probabilities for stars with ≥ 3 measurements. We find 420 stars to be high-probability cluster members, including 137 spectroscopic binaries. These detectable binaries all have orbital periods of less than 104 days, and thus are hard. We have derived orbit solutions for 67 member binary stars, and use our 35 main-sequence binaries with orbit solutions to compare the eccentricity and period distributions with simulated observations of the Hurley et al. (2005) model of M67 (4.5 Gyr). We also compare the spatial distributions of cluster member populations.
We present preliminary results from an observational campaign aimed at the study of the binary fraction and binary radial distribution in Galactic globular clusters. In particular, we concentrate on the ongoing observational campaign for the search of spectroscopic binaries.
Using fistulated calves, the influence of the age, type of dietary protein and weaning on the secretion of chymosin and pepsin by the abomasum were studied. The abomasum secreted both chymosin and pepsin when the animals were fed milk. Chymosin secretion appeared to be independent of the age of the animals, whereas a slow increase in pepsin secretion was observed as the calves aged. Several preruminant animals were fed either a skim-milk diet or a milt substitute in which proteins were provided by fish, soya or whey concentrates. Each of these 3 milk substitutes led to a decrease in chymosin secretion without modification of pepsin secretion. Chymosin secretion was partly restored when the calves were again given a skim-milk diet. At weaning, chymosin secretion dropped abruptly, but the pepsin level was not affected. These results indicate that milk (most probably its casein fraction) is responsible for the activation of chymosin secretion.
Email your librarian or administrator to recommend adding this to your organisation's collection.