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To evaluate newborn fluoxetine exposure at different period on development and behavior of adult rats.
Male rat pups were randomized to be treated once daily with fluoxetine(s.c.) or saline(s.c.) during postnatal day 1∼7 and postnatal day 8∼21. Recorded the body weight. Starting at 90 days of age, all rats were tested with several experimental facilities, including open field test, elevated-plus maze, novelty- suppressed feeding test and forced swim test.
1 Weight gain of rats with fluoxetine exposure during postnatal day 1∼7 were lower than controls (P<0.05).
2 Exploratory behavior decreased and depression anxiety behavior increased in adult rats with neonatal fluoxetine exposure (P<0.05), and more severe with postnatal day 1∼7 exposure (P<0.05).
Newborn fluoxetine exposure may result badness weight gain and depression anxiety behavior in adult rats, and the earlier exposure may accompany the larger risk.
To explore rearing, coping, attributional style and their relations in depression adolescents.
64 adolescents with depressive disorder and 125 normal subjects of similar age, sex were presented with self-made social demographic scale, Egna Minnen av Barndoms Uppfostran-own memories of parental rearing practices in childhood (EMBU), Children attributional style questionnaire (CASQ) and Coping style questionnaire.
1. As to EMBU, there was a significant deficit in parental emotional warmth (p< 0.001) with depression adolescents, and whose parental punishment and strict (p< 0.05), rejection and denial (p< 0.001) were higher than normal ones.
2. As to CASQ, the differences were significant in self-blame (p< 0.001), asking for help (p< 0.001), daydreaming (p< 0.001) and recession (p< 0.05).
3. The difference of attributional pattern was significant (p< 0.001).
4. Mather’ emotional warmth and rejection and denial were both related to adolescents’ coping style and attributional style.
Depressive adolescents had negative coping style and attributional style, and mother’ rearing style may has relation with them.
To explore the characteristics of cerebral activation during the performance of WCST in first-episode, drug-naive schizophrenic patients by functional magnetic resonance imaging,Wisconsin Card Sorting Test (WCST) and Color Card Sorting Test (CCST).
Twenty healthy adults and twenty schizophrenic patients underwent fMRI with a 1.5T MR imager with gradient echo-EPI sequence during the performance of Wisconsin Card Sorting Test (WCST) and Color Card Sorting Test (CCST). The functional images of two groups were analyzed with analysis software. The active volume of interested brain areas and the performance of WCST were compared between healthy group and patient group. Results:(1) The performance of WCST in first-episode drug-naive schizophrenic group were significantly lower than the performance in healthy group(P<0.01) . (2) The images subtracted the functional images of CCST from those of WCST in healthy group suggested that activations were mainly localized in the bilateral frontal lobe, especially the dorsolateral prefrontal cortex,posterior parietal cortices and anterior cingulate gyrus.(3)The patients group showed less activations in left dorsolateral prefrontal cortex(P<0.01), left anterior cingulated (P<0.05),but more activations in left posterior parietal cortices(P<0.05).
The dorsolateral prefrontal cortex and anterior cingulate of first-episode schizophrenic patients are hypofunction,which maybe involved in the executive function disorder in schizophrenia. The hyperactivity of posterior parietal cortices maybe can compensate the hypofrontality in a certain extent.
Personality has been proposed as having a possible effect on the reaction that patients have toward auditory hallucination. However, this factor has not been studied previously. Thus, this study investigated the relationship among demographics, personality, cognition and emotional response in schizophrenics with persistent auditory hallucination. One-hundred and fourteen subjects with persistent auditory hallucination completed the Eysenck Personality Questionnaire, the revised Beliefs about Voices Questionnaire and the Chinese-version Hospital Anxiety and Depression Scale. Structural equation model showed that personality had an effect on beliefs about the hallucination (malevolent or benevolent), which then affected the reaction of patients toward these voices (engages or resists). Their reaction will further affect the anxious or depressed state of the patients. When these hallucinations were categorized into the three levels of omnipotence, beliefs and reactions, the model was more significant than that of one-level model. Persistent auditory hallucination only accounted for a portion of the emotional distress when malevolent or benevolent voices were perceived, and personality characteristics accounted for the remaining emotional distress in schizophrenics. This model helped us understand the relationship between personality, cognition and affective symptoms, such that, when therapists decide what “trait” to change, they can determine at which point to intervene.
Automutilation behavior and Suicidal thinking are common in individuals with bipolar disorder. Few studies have investigated the prevalence of and risk factors for self-injury behavior and Suicidal ideation among adolescent patients.
Patients aged from 13 to 18 years old with bipolar I or II disorder (DSM-IV criteria) diagnosed with structured interviews were evaluated using demographic, parents rearing style and adolescent self-rating life events checklist questionnaires to assess incidence and correlates of automutilation behavior and Suicidal ideation. Demographic and psychosocial characteristics were compared for patients with and without a history of self-injury and suicidal ideation.
More boys attempted self-insult (P= .035)and more girls had suicidal thinking (P= .005). The 44% of patients with a history of automutilation behavior, compared with those without such a history, had more negative life events(P=.000);more paternal punish(P=.024),interfere(P=.004)rejecting and negation(P=.008)and maternal rejecting and negation(P=.020). The 67% of patients with suicidal thinking, compared with those without such a history, had more negative life events(P=.033);more maternal interfere and protection(P=.024).
Our retrospective findings indicate that a history of automutilation behavior and suicidal ideation is associated with a more negative life events and more negative parental rearing style. Greater attention to realizing those at high risks for self-injury behavior and suicidal thinking could have an impact on bipolar disorder among adolescents.
To systematically investigate the influence of electrolyte substrates on Sr-segregation and SrSO4 formation in (LaSr)(CoFe)O3 (LSCF) cathodes in solid oxide fuel cells, model thin films were grown on Gd-doped ceria (GDC) and on Y-doped BaZrO3 (BZY) electrolytes by pulsed laser deposition and heat treated at 800–1000 °C in synthetic air with a trace amount of SO2. A severe SrSO4 formation was observed in LSCF on GDC as compared with the BZY, especially at low temperature. The difference in Sr-segregation and SrSO4 formation on the LSCF was discussed in relation to Sr diffusion and related elemental redistribution across the interfaces.
The present study aim to explore temporal–spatial patterns of water use (WU) efficiency and its influencing factors of maize production in China during 1998–2010. WU and productivity (WP) were quantified by taking irrigation loss into account and the links between WP and nine selected indicators were revealed by the partial least squares regression (PLSR) model. Results showed that national WU and WP in maize production were 138.56 cubic gigametres (Gm3; 0.755 green and 0.245 blue) and 1.079 kg/m3, respectively. WP was enhanced in the present study due to an increase in irrigated crop yield. Provinces located in the middle–lower part of the Yellow River had high proportions of green water and WP, while high proportions of irrigation water and low WP were found in Northwest China. The dosage of pesticides per unit area, relative humidity, average temperature and precipitation were the dominant factors that affected WP. However, the relationships between WP and solar radiation, fertilizer, agricultural machinery power, irrigation proportion and irrigated efficiency were not significant. Findings of the present research may also provide a reference for regional agricultural water management.
Retreatment of tuberculosis (TB) often fails in China, yet the risk factors associated with the failure remain unclear. To identify risk factors for the treatment failure of retreated pulmonary tuberculosis (PTB) patients, we analyzed the data of 395 retreated PTB patients who received retreatment between July 2009 and July 2011 in China. PTB patients were categorized into ‘success’ and ‘failure’ groups by their treatment outcome. Univariable and multivariable logistic regression were used to evaluate the association between treatment outcome and socio-demographic as well as clinical factors. We also created an optimized risk score model to evaluate the predictive values of these risk factors on treatment failure. Of 395 patients, 99 (25·1%) were diagnosed as retreatment failure. Our results showed that risk factors associated with treatment failure included drug resistance, low education level, low body mass index (<18·5), long duration of previous treatment (>6 months), standard treatment regimen, retreatment type, positive culture result after 2 months of treatment, and the place where the first medicine was taken. An Optimized Framingham risk model was then used to calculate the risk scores of these factors. Place where first medicine was taken (temporary living places) received a score of 6, which was highest among all the factors. The predicted probability of treatment failure increases as risk score increases. Ten out of 359 patients had a risk score >9, which corresponded to an estimated probability of treatment failure >70%. In conclusion, we have identified multiple clinical and socio-demographic factors that are associated with treatment failure of retreated PTB patients. We also created an optimized risk score model that was effective in predicting the retreatment failure. These results provide novel insights for the prognosis and improvement of treatment for retreated PTB patients.
Foxtail millet (Setaria italica (L.) P. Beauv.) is a naturally stress-tolerant plant, a major reserve crop and a model for panicoid grasses. The recent completion of the S. italica genome facilitates identification and characterization of WRKY transcription factor family proteins that are important regulators of major plant processes, including growth, development and stress response. The present study identified 103 WRKY transcription factor-encoding genes in the S. italica genome. The genes were named SiWRKY1–SiWRKY103 according to their order on the chromosomes. A comprehensive expression analysis of SiWRKY genes among four different tissues was performed using publicly available RNA sequencing data. Eighty-four SiWRKY genes were more highly expressed in root tissue than in other tissues and nine genes were only expressed in roots. Additionally, real-time quantitative polymerase chain reaction was performed to comprehensively analyse the expression of all SiWRKY genes in response to dehydration. Results indicated that most SiWRKY genes (over 0.8) were up-regulated by drought stress. In conclusion, genome-wide identification and expression profiling of SiWRKY genes provided a set of candidates for cloning and functional analyses in plants’ response to drought stress.
In this paper, a simplified lattice Boltzmann method (SLBM) without evolution of the distribution function is developed for simulating incompressible viscous flows. This method is developed from the application of fractional step technique to the macroscopic Navier-Stokes (N-S) equations recovered from lattice Boltzmann equation by using Chapman-Enskog expansion analysis. In SLBM, the equilibrium distribution function is calculated from the macroscopic variables, while the non-equilibrium distribution function is simply evaluated from the difference of two equilibrium distribution functions. Therefore, SLBM tracks the evolution of the macroscopic variables rather than the distribution function. As a result, lower virtual memories are required and physical boundary conditions could be directly implemented. Through numerical test at high Reynolds number, the method shows very nice performance in numerical stability. An accuracy test for the 2D Taylor-Green flow shows that SLBM has the second-order of accuracy in space. More benchmark tests, including the Couette flow, the Poiseuille flow as well as the 2D lid-driven cavity flow, are conducted to further validate the present method; and the simulation results are in good agreement with available data in literatures.
In this paper, a hybrid lattice Boltzmann flux solver (LBFS) is proposed for simulation of viscous compressible flows. In the solver, the finite volume method is applied to solve the Navier-Stokes equations. Different from conventional Navier-Stokes solvers, in this work, the inviscid flux across the cell interface is evaluated by local reconstruction of solution using one-dimensional lattice Boltzmann model, while the viscous flux is still approximated by conventional smooth function approximation. The present work overcomes the two major drawbacks of existing LBFS [28–31], which is used for simulation of inviscid flows. The first one is its ability to simulate viscous flows by including evaluation of viscous flux. The second one is its ability to effectively capture both strong shock waves and thin boundary layers through introduction of a switch function for evaluation of inviscid flux, which takes a value close to zero in the boundary layer and one around the strong shock wave. Numerical experiments demonstrate that the present solver can accurately and effectively simulate hypersonic viscous flows.
In this paper, a switch function-based gas-kinetic scheme (SF-GKS) is presented for the simulation of inviscid and viscous compressible flows. With the finite volume discretization, Euler and Navier-Stokes equations are solved and the SF-GKS is applied to evaluate the inviscid flux at cell interface. The viscous flux is obtained by the conventional smooth function approximation. Unlike the traditional gas-kinetic scheme in the calculation of inviscid flux such as Kinetic Flux Vector Splitting (KFVS), the numerical dissipation is controlled with a switch function in the present scheme. That is, the numerical dissipation is only introduced in the region around strong shock waves. As a consequence, the present SF-GKS can well capture strong shock waves and thin boundary layers simultaneously. The present SF-GKS is firstly validated by its application to the inviscid flow problems, including 1-D Euler shock tube, regular shock reflection and double Mach reflection. Then, SF-GKS is extended to solve viscous transonic and hypersonic flow problems. Good agreement between the present results and those in the literature verifies the accuracy and robustness of SF-GKS.
The aims of this study were to develop and validate a prediction equation of fat-free mass (FFM) based on bioelectrical impedance analysis (BIA) and anthropometry using air-displacement plethysmography (ADP) as a reference in Asian neonates and to test the applicability of the prediction equations in an independent Western cohort. A total of 173 neonates at birth and 140 at two weeks of age were included. Multiple linear regression analysis was performed to develop the prediction equations in a two-third randomly selected subset and validated on the remaining one-third subset at each time point and in an independent Queensland cohort. FFM measured by ADP was the dependent variable, and anthropometric measures, sex and impedance quotient (L2/R50) were independent variables in the model. Accuracy of prediction equations was assessed using intra-class correlation and Bland–Altman analyses. L2/R50 was the significant predictor of FFM at week two but not at birth. Compared with the model using weight, sex and length, including L2/R50 slightly improved the prediction with a bias of 0·01 kg with 2 sd limits of agreement (LOA) (0·18, −0·20). Prediction explained 88·9 % of variation but not beyond that of anthropometry. Applying these equations to the Queensland cohort provided similar performance at the appropriate age. However, when the Queensland equations were applied to our cohort, the bias increased slightly but with similar LOA. BIA appears to have limited use in predicting FFM in the first few weeks of life compared with simple anthropometry in Asian populations. There is a need for population- and age-appropriate FFM prediction equations.
Overuse of acetolactate synthase (ALS)–inhibiting herbicides in rice has led
to the evolution of halosulfuron-resistant rice flatsedge in Arkansas and
Mississippi. Resistant accessions were cross-resistant to labeled field
rates of ALS-inhibiting herbicides from four different families, in
comparison to a susceptible (SUS) biotype. Resistance index of Arkansas and
Mississippi accessions based on an R/S ratio of the lethal dose required for
50% plant mortality (LD50) to bispyribac-sodium, halosulfuron,
imazamox, and penoxsulam was ≥ 21-fold. Control of Arkansas, Mississippi,
and SUS accessions with labeled field rates of 2,4-D, bentazon, and propanil
was ≥ 93%. An enzyme assay revealed that an R/S ratio for 50% inhibition
(I50) of ALS for halosulfuron was 2,600 and 200 in Arkansas
and Mississippi, respectively. Malathion studies did not reveal enhanced
herbicide metabolism in resistant plants. The ALS enzyme assay and
cross-resistance studies point toward altered a target site as the potential
mechanism of resistance. Trp574–Leu amino acid substitution
within the ALS gene was found in both Arkansas and
Mississippi rice flatsedge accessions using the Illumina HiSeq platform,
which corresponds to the mechanism of resistance found in many weed species.
Field-rate applications of 2,4-D, bentazon, and propanil can be used to
control these ALS-resistant rice flatsedge accessions.
To evaluate the chance of improvement and risk of decline in olfaction among patients with post-traumatic olfactory loss.
This study comprised 80 patients. Changes in olfaction were determined using a visual analogue scale and the ‘Sniffin’ Sticks' test. Logistic regression was used to identify predictors for olfactory changes.
Olfactory changes were observed in 9–35 per cent of patients. The rates of improvement and decline according to visual analogue scale scores were 35 per cent and 10 per cent respectively, whereas those in the Sniffin’ Sticks test were 9 per cent and 11 per cent respectively. There was a predictive link between non-anosmia and decline in Sniffin’ Sticks test scores (odds ratio = 16.61, p = 0.003). A positive correlation was observed between the scores in the first and last examinations (rho = 0.532, p < 0.001).
Patients should be informed that they may experience an improvement or decline in olfaction following post-traumatic olfactory dysfunction. This study provides evidence to support comprehensive counselling regarding prognosis as an integral part of management strategies.
Glyphosate is used in the transition zone to control annual bluegrass in fully dormant warm-season grasses. A suspected resistant (R) biotype of annual bluegrass was identified on a golf course in South Carolina after at least 10 consecutive years of glyphosate application. Greenhouse bioassays revealed the R biotype was 4.4-fold resistant to glyphosate compared with a standard susceptible (S) biotype. Further studies were conducted to investigate the mechanism conferring glyphosate resistance in the R biotype. Leaf discs of both biotypes accumulated shikimate in response to increasing glyphosate concentration, but the glyphosate concentration resulting in 50% EPSP synthase inhibition as a result of shikimate accumulation (I50) was 4.2-fold higher in the R biotype compared with the S biotype. At the whole plant level, similar levels of shikimate accumulation were observed between biotypes at 6 and 24 h after treatment (HAT) with glyphosate, but greater shikimate accumulation occurred in the S biotype at 72, 120, and 168 HAT. Shikimate levels decreased in the R biotype after 72 HAT. There were no differences in 14C-glyphosate absorption between biotypes. However, more 14C-glyphosate translocated out of the treated leaf in the R biotype and into root tissues over time compared with the S biotype. Partial sequencing of the EPSP synthase gene revealed a point mutation that resulted in an Ala substitution at Pro106. Although other mechanisms may contribute to glyphosate resistance, these results confirm a Pro106 to Ala substitution is associated with resistance to glyphosate in the R annual bluegrass biotype.
Smallflower umbrella sedge is a problematic weed in direct-seeded rice in the midsouthern United States. It recently has evolved resistance to the acetolactate synthase (ALS) –inhibiting herbicide halosulfuron in Arkansas rice. Studies were conducted (1) to determine if the resistant biotype is cross resistant to other ALS-inhibiting herbicides, (2) to evaluate alternative herbicide control options, and (3) to determine the mechanism of resistance. Whole-plant bioassay revealed that halosulfuron-resistant plants were not controlled by bispyribac–sodium, imazamox, and penoxsulam at the labeled field rate of each herbicide. The level of resistance to these herbicides, based on the lethal dose needed to kill 50% of plants (LD50) was ≥ 15-fold compared to a susceptible biotype. Both biotypes were controlled >96% with bentazon and propanil and ≤ 23% with quinclorac, thiobencarb, and 2,4-D. Hence, effective control measures exist; albeit, the number of herbicide options appear limited. Based on in vitro ALS enzyme assays, altered target site is the mechanism of resistance to halosulfuron and imazamox. Massively parallel sequencing with the use of the Illumina HiSeq detected an amino acid substitution of Pro197-to-His in the resistant biotype that is consistent with ALS-inhibiting herbicide resistance in other weed species.
We describe three approaches to identify novel product affordances: affordance of absence; insights from lead users, specifically do-it-yourselfers (DIYers); and natural-language searches. While these approaches were separately pursued, we show their connection to each other in this paper. We begin by describing the affordance of absence, inspired by insights on affordances arising from a lack of resources. For example, in the absence of specialized tools, more general tools are used to accomplish similar tasks. Such absence clarifies how other tools could be modified to add relevant features and identifies critical features of the absent tool. In addition, the temporary removal of physical features and objects enables user interaction in ways that may not emerge in their presence. Affordance of absence has the potential to more fully specify affordances for a given object and to help overcome functional fixedness. For the second approach, we describe insights from DIYers obtained from the “IKEA hackers” online community. We consider DIYers lead users for seeking out and exploiting product affordances, often transforming product functions dramatically. We also discuss their projects through the lens of affordance of absence. For the third approach, we outline our natural-language approach to affordance extraction, beginning with consumer product reviews provided for Canadian Tire, a major Canadian retailer. We describe efforts toward automatically identifying less common affordances, and the use of cue phrases to highlight insightful DIY transformations from the IKEA hackers community. Finally, we comment on the potential value of this work for product design in general.
Studies have suggested that maternal PUFA status during pregnancy may influence early childhood allergic diseases, although findings are inconsistent. We examined the relationship between maternal PUFA status and risk of allergic diseases in early childhood in an Asian cohort. Maternal plasma samples from the Growing Up in Singapore Towards Healthy Outcomes mother–offspring cohort were assayed at 26–28 weeks of gestation for relative abundance of PUFA. Offspring (n 960) were followed up from 3 weeks to 18 months of age, and clinical outcomes of potential allergic diseases (rhinitis, eczema and wheezing) were assessed by repeated questionnaires. Skin prick testing (SPT) was also performed at the age of 18 months. Any allergic disease with positive SPT was defined as having any one of the clinical outcomes plus a positive SPT. The prevalence of a positive SPT, rhinitis, eczema, wheezing and any allergic disease with positive SPT was 14·1 % (103/728), 26·5 % (214/808), 17·6 % (147/833), 10·9 % (94/859) and 9·4 % (62/657), respectively. After adjustment for confounders, maternal total n-3, n-6 PUFA status and the n-6:n-3 PUFA ratio were not significantly associated with offspring rhinitis, eczema, wheezing, a positive SPT and having any allergic disease with positive SPT in the offspring (P>0·01 for all). A weak trend of higher maternal n-3 PUFA being associated with higher risk of allergic diseases with positive SPT in offspring was observed. These findings do not support the hypothesis that the risk of early childhood allergic diseases is modified by variation in maternal n-3 and n-6 PUFA status during pregnancy in an Asian population.