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The Hkakabo Razi region located in northern Myanmar is an Important Bird Area and part of the Eastern Himalayan Biodiversity Hotspot. Within the framework of the World Heritage Convention to enlist the site under criterion (ix) and (x), we conducted a biodiversity assessment for passerine birds using DNA barcoding and other molecular markers. Of the 441 bird species recorded, we chose 16 target species for a comparative phylogeographic study. Genetic analysis was performed for a larger number of species and helped identifying misidentified species. We found phylogeographic structure in all but one of the 16 study species. In 13 species, populations from northern Myanmar were genetically distinctive and local mitochondrial lineages differed from those found in adjacent regions by 3.9–9.9% uncorrected genetic distances (cytochrome-b). Since the genetic distinctiveness of study populations will be corroborated by further differences in morphology and song as in other South-East Asian passerines, many of them will be candidates for taxonomic splits, or in case an older taxon name is not available, for the scientific description of new taxa. Considering the short time frame of our study we predict that a great part of undetected faunal diversity in the Hkakabo Razi region will be discovered.
Background: The interaction between mutations in two or more genes is increasingly recognised as an important contributor to the phenotypic variability in genetic disorders. Co-occurrence of variants in SQSTM1 and TIA1 is reported as a cause of myopathy in 3 prior cases, but limited clinical data were presented. We present detailed clinical features of a family with two siblings having a distal myopathy with rimmed vacuoles (DMRV), and genetic variants in SQSTM1 and TIA1. Methods: Clinicopathologic study of a family with DMRV to describe clinical features, laboratory and neurophysiology studies, neuroimaging, and genetic sequencing. Results: Two siblings with variants in SQSTM1 and TIA1 developed myopathy in their early 60’s, with early involvement of ankle dorsiflexors and finger extensors. A decade after onset, patients remain ambulatory and have not developed cardiac or respiratory complications. MRI of the legs showed selective involvement of adductor magnus, vastus lateralis, and in lower legs the anterior compartment and medial gastrocnemius. Muscle pathology demonstrated rimmed vacuoles, disrupted myofibrillar architecture, and mislocalised TDP43. Two unaffected family members had one genetic variant but not both. Conclusions: We describe a fourth family with co-occurrence of TIA1 and SQSTM1 genetic variants and describe their detailed phenotype. Future study should address the mechanism of the interaction between these two variants.
Background: When measuring young Duchenne Muscular Dystrophy (DMD) patients’ health-related quality of life (HRQoL), parent-proxy reports are heavily relied on. Therefore, it is imperative that the relationship between parent-proxy and child self-report HRQoL is understood. This study examined the level of agreement between children and their parent-proxy rating of the child’s HRQoL. Methods: We used FOR-DMD clinical trial baseline data. HRQoL, measured using the PedsQL inventory, was reported by 178 parent and child (ages 4 to 7 years) dyads. Intracorrelation coefficients (ICC) measured absolute agreement while paired t-tests determined differences in the average HRQoL ratings between groups. Results: The level of agreement between child and parent-proxy ratings of HRQoL was poor for the generic PedsQL scale (ICC: 0.29) and its subscales; and, similarly low for the neuromuscular disease module (ICC:0.16). On average, parents rated their child’s HRQoL as poorer than the children rated themselves in all scales except for psychosocial and school functioning. Conclusions: Child and parent-proxy HRQoL ratings are discordant in this study sample, as occurs in other chronic pediatric diseases. This should be taken into account when interpreting clinical and research HRQoL findings in this population. Future studies should examine reasons for parents’ perception of poorer HRQoL than that reported by their children.
The prediction of solar flares, eruptions, and high energy particle storms is of great societal importance. The data mining approach to forecasting has been shown to be very promising. Benchmark datasets are a key element in the further development of data-driven forecasting. With one or more benchmark data sets established, judicious use of both the data themselves and the selection of prediction algorithms is key to developing a high quality and robust method for the prediction of geo-effective solar activity. We review here briefly the process of generating benchmark datasets and developing prediction algorithms.
The purpose of this paper is to explore a resolution for the Faint Young Sun Paradox that has been mostly rejected by the community, namely the possibility of a somewhat more massive young Sun with a large mass loss rate sustained for two to three billion years. This would make the young Sun bright enough to keep both the terrestrial and Martian oceans from freezing, and thus resolve the paradox. It is found that a large and sustained mass loss is consistent with the well observed spin-down rate of Sun-like stars, and indeed may be required for it. It is concluded that a more massive young Sun must be considered a plausible hypothesis.
Fletcher & Martens have successfully modeled solar hard X-ray sources observed at the top and footpoints of flaring magnetic loops with a Fokker-Planck type particle transport code. I show here that there are invariances in the Fokker-Planck equations that make these results applicable to environments with vastly different physical parameters, such as hard X-ray flares in accretion disks in active galactic nuclei, and in RS CVn and ALGOL type binaries.
The Sun’s activity has been evolving in the ascending phase of Solar Cycle 23 since 1996. Similarly, the research on solar activity is also in the ascending phase of a new active period. Numerous new results have been obtained from a large amount of space and ground observations covering a wide spectral range. In particular, observations with YOHKOH, SOHO, and TRACE have revealed a multitude of phenomena and processes in the solar atmosphere which provide us a new picture of the Sun.
During the September 1996 campaign of multi-wavelength observations with the SOHO (SUMER, CDS, EIT, MDI, LASCO) and Yohkoh (SXT) spacecraft, the HAO Mauna Loa Solar Observatory Chromospheric Helium Imaging Photometer and the Nobeyama radioheliograph, a filament disparition brusque (DB) associated with a Coronal Mass Ejection (CME) was observed. The timeline of this complex event, which lasted for tens of hours, shows that the CME had started before the DB of a filament, while the main “bubble” of the CME was probably launched hours after the DB from the so-called “zipper” region. All these suggest that a general reorganization of large-scale fields was taking place on the Sun, and both the DB and the CME were symptoms of this.
There is a need to design intensive cropping systems that can reap multiple benefits from annual forages including animal feed, soil fertility and weed control. Considering pea/oat (Pisum sativum cv. 40–10/Avena sativa cv. Legget) as a standard green manure, this study investigated the productivity, weed competitiveness, utilization and nitrogen (N) benefit from grazed and ungrazed green manures to spring wheat (Triticum aestivum cv. Waskada) and fall rye (Secale cereale cv. Hazlet). A set of 3-year experiments was carried out in Carman, Manitoba, Canada in 2009, and was repeated in 2010 and 2011. Green manures were grazed by 2–3 ewes and 2–5 lambs for 24 h (1111–1667 sheep days per ha). Averaged over experiments pea/oat mix, hairy vetch (Vicia villosa L.) and sweetclover (Melilotus officinalis cv. Norgold) above-ground dry matter (DM) production were 5036, 5032 and 4064 kg ha−1, respectively. Lentil (Lens culinaris cv. Indianhead), a mixture of seven species and soybean (Glycine max cv. Prudence) produced the least amount of DM over 3 years; 3589, 3551, 3174 kg ha−1, respectively. Pea/oat and hairy vetch were the most weed-competitive species and, averaged over 3 years, contained less than 15% weed DM. Utilization of green manures by grazing animals varied little among species across years and ranged from 28 to 86% for individual species and years. When combined across experiments grazing increased N availability to the wheat crop. The grazing effect was significant for wheat DM production, N uptake and grain N, but not significant for yield across experiments. Averaged over 3 years, wheat took up 107 kg N ha−1 from grazed plots versus 98 kg N ha−1 from ungrazed plots. A significant species×management interaction for total (wheat+fall rye) N uptake in 2009 indicated that increasing the proportion of legumes in the green manure increased N benefit from grazing. Fall rye productivity was not affected by grazing. We recommend pea/oat and hairy vetch as two green manure species to enhance the overall system performance to achieve high level of DM production, good weed competition, utilization by sheep and provision of N benefit to the following wheat and fall rye crops.
We investigated a mixed outbreak of Legionnaires' disease (LD) and Pontiac fever (PF) at a military base to identify the outbreak's environmental source as well as known legionellosis risk factors. Base workers with possible legionellosis were interviewed and, if consenting, underwent testing for legionellosis. A retrospective cohort study collected information on occupants of the buildings closest to the outbreak source. We identified 29 confirmed and probable LD and 38 PF cases. All cases were exposed to airborne pathogens from a cooling tower. Occupants of the building closest to the cooling tower were 6·9 [95% confidence interval (CI) 2·2–22·0] and 5·5 (95% CI 2·1–14·5) times more likely to develop LD and PF, respectively, than occupants of the next closest building. Thorough preventive measures and aggressive responses to outbreaks, including searching for PF cases in mixed legionellosis outbreaks, are essential for legionellosis control.
The motivation for our research was to study the correlation between the chirality of filaments and the handedness (S- or Z-shape) of sigmoids. It was assumed that sigmoids would mostly coincide with filaments and that the S-shaped sigmoids would correlate well with filaments of sinistral chirality, which we found that to be at best a very weak relation. Since we had a full solar cycle of filament metadata at hand it was easy to verify the supposedly known hemispheric preference of filament chirality. We discovered that the hemispheric chirality rule was confirmed for the epoch where a thorough manual study had been performed, but that at other phases of the solar cycle the rule seems to disappear and sometimes even reverse.
Vestibular nerve section is a highly effective procedure for the control of vertigo in patients with Ménière's disease. However, hearing loss is a possible complication. If hearing loss occurs after vestibular nerve section, magnetic resonance imaging should make it possible to establish the presence or absence of an intact cochlear nerve.
Case report and review of the world literature concerning cochlear implantation after vestibular nerve section.
We present a patient who developed subtotal hearing loss after vestibular nerve section. Magnetic resonance imaging was used to verify the presence of an intact cochlear nerve, enabling successful cochlear implantation.
To our knowledge, this is the first reported case of cochlear implantation carried out after selective vestibular nerve section. Given recent advances in cochlear implantation, this case indicates that it is essential to make every effort to spare the cochlear nerve if vestibular nerve section is required. If hearing loss occurs after vestibular nerve section, magnetic resonance imaging should be undertaken to establish whether the cochlear nerve is intact.
Williams syndrome is a neurodevelopmental genetic disorder caused by a hemizygous deletion on chromosome 7q11.23, resulting in atypical brain structure and function, including abnormal morphology of the corpus callosum. An influence of handedness on the size of the corpus callosum has been observed in studies of typical individuals, but handedness has not been taken into account in studies of callosal morphology in Williams syndrome. We hypothesized that callosal area is smaller and the size of the splenium and isthmus is reduced in individuals with Williams syndrome compared to healthy controls, and examined age, sex, and handedness effects on corpus callosal area. Structural magnetic resonance imaging scans were obtained on 25 individuals with Williams syndrome (18 right-handed, 7 left-handed) and 25 matched controls. We found that callosal thickness was significantly reduced in the splenium of Williams syndrome individuals compared to controls. We also found novel evidence that the callosal area was smaller in left-handed participants with Williams syndrome than their right-handed counterparts, with opposite findings observed in the control group. This novel finding may be associated with LIM-kinase hemizygosity, a characteristic of Williams syndrome. The findings may have significant clinical implications in future explorations of the Williams syndrome cognitive phenotype.
Agricultural production systems that reduce the use of in-crop herbicides
could greatly reduce risks of environmental damage and the development of
herbicide-resistant weeds. Few studies have investigated the long-term
effects of in-crop herbicide omissions on weed seedbank community size and
structure. A crop-rotation study was sampled 10 yr after a strictly annual
rotation and an annual/perennial rotation were exposed to different in-crop
herbicide omission treatments. In-crop herbicides were applied either in all
annual crops (control), omitted from oats only, or omitted from both flax
and oats. Seedbank densities were greatest when in-crop herbicides were
omitted from flax and oats, and this treatment also reduced crop yield.
Shannon-Wiener diversity differed among crops in the annual crop rotation
and among herbicide omission treatments in the perennial rotation. Herbicide
omissions changed the weed-community structure in flax and in wheat and
canola crops in the annual rotation enough to warrant alternate control
methods in some treatments. The magnitude of the effects on the seedbank
parameters depended largely on the competitive ability of the crop in which
herbicides were omitted. No yield response to omitting herbicides in oats
indicated that standard weed management practices have reduced weed
populations below yield-loss thresholds.
The ternary transition metal nitrides of general formulation AMN2 (A = alkaline earth metal, M = transition metal) have been systematically studied. These compounds have been synthesised by high temperature solid state reaction from their component binary nitrides in sealed systems. The structures of these materials have been determined by powder X-ray diffraction (PXD) and two layered structure-types (α-NaFeO2-type and KCoO2-type) have been observed, thus far. Intriguingly, magnetic measurements performed on nitride samples indicate they may not be diamagnetic (d = 0, S = 0) as their nominal stoichiometry suggests.
The period doubling renormalization operator was introduced by Feigenbaum and by Coullet and Tresser in the 1970s to study the asymptotic small-scale geometry of the attractor of one-dimensional systems that are at the transition from simple to chaotic dynamics. This geometry turns out not to depend on the choice of the map under rather mild smoothness conditions. The existence of a unique renormalization fixed point that is also hyperbolic among generic smooth-enough maps plays a crucial role in the corresponding renormalization theory. The uniqueness and hyperbolicity of the renormalization fixed point were first shown in the holomorphic context, by means that generalize to other renormalization operators. It was then proved that, in the space of C2+α unimodal maps, for α>0, the period doubling renormalization fixed point is hyperbolic as well. In this paper we study what happens when one approaches from below the minimal smoothness thresholds for the uniqueness and for the hyperbolicity of the period doubling renormalization generic fixed point. Indeed, our main result states that in the space of C2 unimodal maps the analytic fixed point is not hyperbolic and that the same remains true when adding enough smoothness to get a priori bounds. In this smoother class, called C2+∣⋅∣, the failure of hyperbolicity is tamer than in C2. Things get much worse with just a bit less smoothness than C2, as then even the uniqueness is lost and other asymptotic behavior becomes possible. We show that the period doubling renormalization operator acting on the space of C1+Lip unimodal maps has infinite topological entropy.
The prevalence of Cryptosporidium in calves younger than 10 weeks was estimated in a cross-sectional epidemiological study on 100 dairy (n=499) and 50 beef (n=333) farms in East Flanders (Belgium), using a previously evaluated immunofluorescence assay (Merifluor®). The calf prevalence was 37% (95% Probability Interval (PI): 7–70%) in dairy calves and 12% (95% PI: 1–30%) in beef calves. To elucidate the genetic diversity, the Cryptosporidium 18S ribosomal DNA and the 70 kDa heat shock protein gene were targeted. In the majority of the samples C. parvum was present, although C. bovis was also identified, all but one in calves older than 1 month. The porcine-specific C. suis was identified in 1 beef calf. Subtyping of C. parvum positive isolates by sequence analysis of the 60 kDa glycoprotein gene indicated the presence of 4 allele IIa subtypes, along with 1 subtype IIdA22G1. The subtype IIaA15G2R1 was most prevalent, next to subtype IIaA13G2R1 and IIaA16G2R1, and a new subtype IIaA14G2R1. The results of the present study indicate a high prevalence of Cryptosporidium infections in calves in Belgium and confirm that these calves should be considered as a potential zoonotic reservoir for human infections.
The skeletal anatomy of the Early Permian eureptile Thuringothyris mahlendorffae from the Bromacker Quarry, Germany, is redescribed on the basis of several new specimens. The taxon retains some plesiomorphic characters, such as an ectopterygoid and a tabular, but it also possesses low neural spines and nonswollen neural arches, a combination that is unique for early eureptiles. A phylogenetic analysis places Thuringothyris as the sister taxon of Captorhinidae, excluding any potential “protorothyridid” affinities. Implications of this study are that the swollen neural arches of captorhinids and araeosceloids might have evolved independently, that a downturned rostrum occurred only later in captorhinid evolution, and that the European Permian is important to the understanding of the origin of eureptiles.