Traumatic brain injury (TBI) is prevalent among veterans and military personnel. These individuals present with increased rates of co-morbid mental health conditions and are at increased risk for suicide. Evidence-based treatments are needed to serve this population. A systematic review was conducted in order to determine the state of the science with respect to interventions aimed at improving mental health outcomes among veterans and military personnel. Results indicate that only three published articles exist that met inclusion criteria for this systematic review. All three study designs were observational in nature. Significant risk of bias was noted. The body of evidence was rated according to the GRADE approach. Although the published work marks an important starting point in evaluating evidence-based treatments for veterans and military personnel with TBI, the overall quality of evidence was determined to be very low. Implications for both future research and current practice are discussed.