The illegal drug trade has become a serious threat for the Americas. Is a multilateral approach to combat it possible? This article proposes that the United States and Latin America are finding ways to use multilateral organisms to confront this threat and examines as an example the role of CICAD in setting a cooperative agenda to develop an antidrug regime. CICAD has established common ground for long-term cooperation in certain areas. But common drug strategies in the Americas require the support of the United States and the cooperation of Latin American states, both of which are still works in progress. Therefore the future of the CICAD-inspired antidrug regime will depend on whether the United States and Latin America will cooperate to define the illegal drug threat in the same way and bestow on CICAD the authority necessary to address it.