This paper presents updated analyses on the genetic associations of sleep disruption in individuals with Alzheimer’s disease (AD). We published previously a study of the association between single nucleotide polymorphisms (SNPs) found in eight genes related to circadian rhythms and objective measures of sleep-wake disturbances in 124 individuals with AD. Here, we present new relevant analyses using polygenic risk scores (PRS) and variable number tandem repeats (VNTRs) enumerations. PRS were calculated using the genetic data from the original participants and relevant genome wide association studies (GWAS). VNTRs for the same circadian rhythm genes studied with SNPs were obtained from a separate cohort of participants using whole genome sequencing (WGS). Objectively (wrist actigraphy) determined wake after sleep onset (WASO) was used as a measure of sleep disruption. None of the PRS were associated with sleep disturbance. Computer analyses using VNTRseek software generated a total of 30 VNTRs for the circadian-related genes but none appear relevant to our objective sleep measure. In addition, of 71 neurotransmitter function-related genes, 29 genes had VNTRs that differed from the reference VNTR, but it was not clear if any of these might affect circadian function in AD patients. Although we have not found in either the current analyses or in our previous published analyses of SNPs any direct linkages between identified genetic factors and WASO, research in this area remains in its infancy.

High-mass X-ray binaries (HMXBs) provide an exciting window into the underlying processes of both binary as well as massive star evolution. Because HMXBs are systems containing a compact object accreting from a high-mass star at close orbital separations they are also likely progenitors of gamma-ray bursts and gravitational wave sources. We present classification and age measurements for HMXBs in M33 using a combination of deep Chandra X-ray imaging, and archival Hubble Space Telescope data. We constrain the ages of the HMXB candidates by fitting the color-magnitude diagrams of the surrounding stars, which yield the star formation histories of the surrounding region. Unlike the age distributions measured for HMXB populations in the Magellanic Clouds, the age distribution for the HMXB population in M33 contains a number of extremely young (<5 Myr) sources. We discuss these results the context of the effect of host galaxy properties on the observed HMXB population.

The building blocks of planets in planet-forming (“protoplanetary”) disks are assembled early in the lifetime of a young star. The gas disks are relatively short-lived, with a half-life of about 3 million years, as chemical reactions modify the reservoir of material from the natal molecular cloud. Spitzer Space Telescope Infrared Spectrograph (IRS) spectra of protoplanetary disks around T Tauri stars show emission from H2O and absorption from other gases, sometimes consistent with formaldehyde, H2CO , and other times consistent with formic acid, HCOOH, in the 5-7.5 μm region. SOFIA-EXES spectra of YSOs that follow up on these Spitzer-IRS studies are presented. How the gaseous features observed between 5-7.5 μm relate to those at other wavelengths is discussed. This work suggests that water and organic molecules, which are crucial for life as we know it, are present in the habitable zones of stars at a very early age [of 1-3 million years].

Accurate quantification of rates of glacier mass loss is critical for managing water resources and for assessing hazards at ice-clad volcanoes, especially in arid regions like southern Peru. In these regions, glacier and snow melt are crucial dry season water resources. In order to verify previously reported rates of ice area decline at Nevado Coropuna in Peru, which are anomalously rapid for tropical glaciers, we measured changes in ice cap area using 259 Landsat images acquired from 1980 to 2014. We find that Coropuna Ice Cap is presently the most extensive ice mass in the tropics, with an area of 44.1 km2, and has been shrinking at an average area loss rate of 0.409 km2 a−1 (~0.71% a−1) since 1980. Our estimated rate of change is considerably lower than previous studies (1.4 km2 a−1 or ~2.43% a−1), but is consistent with other tropical regions, such as the Cordillera Blanca located ~850 km to the NW (~0.68% a−1). Thus, if glacier recession continues at its present rate, our results suggest that Coropuna Ice Cap will likely continue to contribute to water supply for agricultural and domestic uses until ~2120, which is nearly 100 years longer than previously predicted.

We develop scholarship on status in international politics by focusing on the social dimension of small and middle power status politics. This vantage opens a new window on the widely-discussed strategies social actors may use to maintain and enhance their status, showing how social creativity, mobility, and competition can all be system-supporting under some conditions. We extract lessons for other thorny issues in status research, notably questions concerning when, if ever, status is a good in itself; whether it must be a positional good; and how states measure it.

We present initial results on a survey of high-mass X-ray binaries (HMXBs) in the nearby, star-forming spiral galaxy M33. The HMXB population in M33 is identified and characterized using a combination of deep Chandra X-ray imaging and archival Hubble Space Telescope (HST) observations. We determine ages for the HMXBs to ~5 Myr precision from fits to the color-magnitude diagrams (CMDs) of the surrounding stars and the resultant star formation histories (SFHs). The HMXBs in our M33 sample have measured ages, as well as candidate optical counterparts identified from HST photometry.

Massive stars are intrinsically rare and therefore present a challenge to understand from a statistical perspective, especially within the Milky Way. We recently conducted follow-up observations to the Panchromatic Hubble Andromeda Treasury (PHAT) survey that were designed to detect more than 10,000 emission line stars, including WRs, by targeting regions in M31 previously known to host large numbers of young, massive clusters and very young stellar populations. Because of the existing PHAT data, we are able to derive an effective temperature, bolarimetric luminosity, and extinction for each of our detected stars. We report on preliminary results of the massive star population of our dataset and discuss how our results compare to previous studies of massive stars in M31.