The quenching of cluster satellite galaxies is inextricably linked to the suppression of their cold interstellar medium (ISM) by environmental mechanisms. While the removal of neutral atomic hydrogen (H i) at large radii is well studied, how the environment impacts the remaining gas in the centres of galaxies, which are dominated by molecular gas, is less clear. Using new observations from the Virgo Environment traced in CO survey (VERTICO) and archival H i data, we study the H i and molecular gas within the optical discs of Virgo cluster galaxies on 1.2-kpc scales with spatially resolved scaling relations between stellar ($\Sigma_{\star}$), H i ($\Sigma_{\text{H}\,{\small\text{I}}}$), and molecular gas ($\Sigma_{\text{mol}}$) surface densities. Adopting H i deficiency as a measure of environmental impact, we find evidence that, in addition to removing the H i at large radii, the cluster processes also lower the average $\Sigma_{\text{H}\,{\small\text{I}}}$ of the remaining gas even in the central $1.2\,$kpc. The impact on molecular gas is comparatively weaker than on the H i, and we show that the lower $\Sigma_{\text{mol}}$ gas is removed first. In the most H i-deficient galaxies, however, we find evidence that environmental processes reduce the typical $\Sigma_{\text{mol}}$ of the remaining gas by nearly a factor of 3. We find no evidence for environment-driven elevation of $\Sigma_{\text{H}\,{\small\text{I}}}$ or $\Sigma_{\text{mol}}$ in H i-deficient galaxies. Using the ratio of $\Sigma_{\text{mol}}$-to-$\Sigma_{\text{H}\,{\small\text{I}}}$ in individual regions, we show that changes in the ISM physical conditions, estimated using the total gas surface density and midplane hydrostatic pressure, cannot explain the observed reduction in molecular gas content. Instead, we suggest that direct stripping of the molecular gas is required to explain our results.

Here, we present the results of carbon isotope and elemental analysis of one-year-old Pinus Sylvestris L. needles collected in 2021 from 10 sampling sites in a highly populated and industrialized area of Poland. The needles were exposed to air pollution for one year. The chemical analysis of the samples was performed using different methods: radiocarbon analysis by accelerator mass spectrometry, stable isotope analysis using isotope ratio mass spectrometry, and elemental analysis by inductively coupled plasma-atomic emission spectroscopy. Variations in the carbon isotopes and elemental composition of pine needles were due to a mixture of carbon dioxide originating from different sources such as households, vehicle traffic, and industrial factories.

This systematic literature review aimed to provide an overview of the characteristics and methods used in studies applying the disability-adjusted life years (DALY) concept for infectious diseases within European Union (EU)/European Economic Area (EEA)/European Free Trade Association (EFTA) countries and the United Kingdom. Electronic databases and grey literature were searched for articles reporting the assessment of DALY and its components. We considered studies in which researchers performed DALY calculations using primary epidemiological data input sources. We screened 3053 studies of which 2948 were excluded and 105 studies met our inclusion criteria. Of these studies, 22 were multi-country and 83 were single-country studies, of which 46 were from the Netherlands. Food- and water-borne diseases were the most frequently studied infectious diseases. Between 2015 and 2022, the number of burden of infectious disease studies was 1.6 times higher compared to that published between 2000 and 2014. Almost all studies (97%) estimated DALYs based on the incidence- and pathogen-based approach and without social weighting functions; however, there was less methodological consensus with regards to the disability weights and life tables that were applied. The number of burden of infectious disease studies undertaken across Europe has increased over time. Development and use of guidelines will promote performing burden of infectious disease studies and facilitate comparability of the results.

Background: In May 2018, The Joint Commission, The Pew Charitable Trusts, and the CDC cosponsored a meeting of experts who identified 6 evidence-based leading practices that antimicrobial stewardship programs (ASPs) should be doing beyond having basic infrastructure for improving antibiotic prescribing. The Joint Commission Department of Research working with external experts in 2020 conducted a prevalence study to assess what proportion of Joint Commission-accredited hospitals had implemented the 6 leading practices identified (results presented at SHEA Spring 2021). In this qualitative study, we collected information about how hospitals implemented ASP leading practices to identify facilitators and barriers to implementation among diverse hospitals. Methods: We conducted in-depth telephone interviews with a subset of ASP leaders from hospitals that participated in the 2020 prevalence study. We used purposive sampling to select 30 hospitals from 288 hospitals based on leading practices implemented, hospital size, and system membership. An experienced qualitative researcher (M.K.) not previously affiliated with the Joint Commission interviewed all participants using a semistructured interview guide. The framework method of analysis was used to review and organize data. We used the constant comparative approach to ensure that factors were not missed. Each transcript was reviewed by at least 2 researchers who compared coded findings in group discussion sessions. Two researchers independently identified key factors and combined findings following discussion and review. We focused on super factors that are relevant to implementing multiple leading practices. Results: ASP leaders from 30 hospitals were interviewed. Participating hospitals were evenly distributed across hospital size (10 small, 10 medium, 10 large) and membership in a health system (16 system, 14 nonsystem). At least 14, (46.7%) interviewees had pharmacist in their title; 11 (36.7%) had pharmacist-antimicrobial stewardship; and 5 (16.6%) had other titles (eg, infection preventionist). Super factors included ASP team capacity, ID expertise, having a physician champion, relationships with clinicians and relevant departments, structure of electronic health records, adequate software, and information technology resources. Small and rural nonsystem hospitals often lacked resources related to ID expertise, dedicated staff, and software tools, whereas hospitals that belong to a system benefit from centralized ID expertise and technical infrastructure provided. Conclusions: Specific factors related to personnel, relationships and IT resources have an outsized impact on implementing multiple leading antimicrobial stewardship practices in hospitals. Hospital ASPs could benefit by targeting resources toward these areas.

Funding: None

Disclosures: None

Philipsburgite has been redefined as the intermediate member of the goldhillite–philipsburgite–kipushite isomorphous series with the ideal formula Cu5Zn[(AsO4)(PO4)](OH)6⋅H2O due to the site-selective As–P substitution. The new mineral goldhillite, ideally Cu5Zn(AsO4)2(OH)6⋅H2O [or Cu5Zn(AsO4)(AsO4)(OH)6⋅H2O], is the arsenate end-member of this series. Goldhillite occurs on fracture surfaces in a rock comprised mostly of quartz with iron hydroxides in association with mixite, cornwallite and conichalcite. Goldhillite forms transparent, bright emerald-green, tabular crystals with vitreous lustre, flattened on {100}, up to 1 mm across and in rosettes up to 1.5 mm. The mineral is brittle with uneven fracture and perfect cleavage on {100}; the Mohs hardness is 3.5. The calculated density for the holotype is 4.199 g cm–3. The Raman spectrum is consistent with the presence of H2O-molecules, OH-groups, AsO4 tetrahedra and traces of PO4. Electron microprobe analyses of goldhillite (H2O content based on the crystal structure) provided: CuO 48.91, ZnO 13.18, As2O5 26.06, P2O5 3.25, H2O 8.97, total 100.37 wt.%. The empirical formula for goldhillite based on O = 15 apfu is (Cu4.69Zn1.23)Σ5.92(As0.86P0.18O4)2(OH)5.61⋅H2O. The crystal structures of goldhillite and philipsburgite were determined using single-crystal X-ray diffraction data and refined to R1 = 0.054 (for 2365 I > 2σI reflections) and 0.052 (for 2308 I > 2σI reflections), respectively. Goldhillite is monoclinic, P21/c, a = 12.3573(5), b = 9.2325(3), c = 10.7163(4) Å, β = 97.346(4)°, V = 1212.59(8) Å3 and Z = 4. Philipsburgite is monoclinic, P21/c, a = 12.3095(9), b = 9.2276(3), c = 10.7195(3) Å, β = 97.137(7)°, V = 1208.16(10) Å3 and Z = 4. The strongest lines of the powder X-ray diffraction pattern of goldhillite [d, Å (I, %)(hkl)] are: 4.09 (28)(300), 3.41 (23)(12$\bar{2}$, 221, 311), 2.57 (100)(132, 11$\bar{4}$, 20$\bar{4}$), 2.17 (18)(42$\bar{3}$, 332), 1.95 (22)(432) and 1.54 (20)(13$\bar{6}$, 060). Goldhillite is named after its type locality, the Gold Hill mine, Tooele County, Utah, USA.

Peter Neumann was a major figure in UK mathematics during a career spanning over 50 years. His parents, Bernhard and Hanna Neumann, were group theorists, so it was perhaps inevitable that Peter would become a specialist in the same area. A notable occurrence, and a sign of things to come, was the publication in 1962 of a joint paper with his parents which gave rise to the concept of an NNN group. There can be few instances in mathematics of three members of the same family co-authoring a paper. His parents spent many years in Australia and Peter maintained strong links with that country throughout his own professional life.

We determined the chemical composition of pine needles to monitor environmental contamination in an urban forest environment in the most industrialized part of southern Poland. The concentrations of radiocarbon (14C), trace elements (Cr, Co, Ni, Cu, Zn, Rb, Sr, Ba, Ce, Pb) and the Pb isotope composition were measured in needles from Pinus sylvestris L. growing in nine urban forests near five factories. The investigated young pine needles were collected in January 2013 and September 2013, respectively. 14C concentration was determined by liquid scintillation counter, trace elemental concentration and Pb isotope ratio were determined by ICP-MS and MC-ICP-MS, respectively. Analysis of trace metal pollution is based on the assumption that element concentrations in tree foliage represent element availability in the environment. Different space-time patterns of element accumulation in pine needles were observed. The variation in isotopic composition reflects a mix between different anthropogenic sources.

Stable carbon isotope ratios and radiocarbon (14C) concentrations in samples of pine wood (AD 1975–2012) from 3 sites, as well as needles (AD 2012–2014) collected from 15 sites, in a heavily urbanized area in proximity to heavy industrial factories in Poland were analyzed as bio-indicators of CO2 emissions. The sampling sites were located at different distances from point sources. The stable isotopic composition was determined using an isotope ratio mass spectrometer, and the 14C concentration was determined using a liquid scintillation counter and an accelerator mass spectrometer. Spatial and temporal variability of δ13C and Δ14C in tree ring cellulose and needles was noted in all regions. A negative correlation between δ13C tree ring cellulose and anthropogenic CO2 emissions has been observed. The ratio of δ13C in tree ring cellulose to δ13C in needles created in the same year is equal to 1.2 at the investigated sites.

The deep subsurface of other planetary bodies is of special interest for robotic and human exploration. The subsurface provides access to planetary interior processes, thus yielding insights into planetary formation and evolution. On Mars, the subsurface might harbour the most habitable conditions. In the context of human exploration, the subsurface can provide refugia for habitation from extreme surface conditions. We describe the fifth Mine Analogue Research (MINAR 5) programme at 1 km depth in the Boulby Mine, UK in collaboration with Spaceward Bound NASA and the Kalam Centre, India, to test instruments and methods for the robotic and human exploration of deep environments on the Moon and Mars. The geological context in Permian evaporites provides an analogue to evaporitic materials on other planetary bodies such as Mars. A wide range of sample acquisition instruments (NASA drills, Small Planetary Impulse Tool (SPLIT) robotic hammer, universal sampling bags), analytical instruments (Raman spectroscopy, Close-Up Imager, Minion DNA sequencing technology, methane stable isotope analysis, biomolecule and metabolic life detection instruments) and environmental monitoring equipment (passive air particle sampler, particle detectors and environmental monitoring equipment) was deployed in an integrated campaign. Investigations included studying the geochemical signatures of chloride and sulphate evaporitic minerals, testing methods for life detection and planetary protection around human-tended operations, and investigations on the radiation environment of the deep subsurface. The MINAR analogue activity occurs in an active mine, showing how the development of space exploration technology can be used to contribute to addressing immediate Earth-based challenges. During the campaign, in collaboration with European Space Agency (ESA), MINAR was used for astronaut familiarization with future exploration tools and techniques. The campaign was used to develop primary and secondary school and primary to secondary transition curriculum materials on-site during the campaign which was focused on a classroom extra vehicular activity simulation.

Children with chronic illness often experience difficulties at school, yet little is known about the impact of the child's illness on siblings’ school experiences. This study investigated parents’ perceptions of siblings’ school experiences and school support. We conducted semi-structured telephone interviews with 27 parents of children with a chronic illness who had a sibling or siblings (4–25 years), representing the experiences of 31 siblings. Interviews were audio-recorded, transcribed, and analysed using content analysis. Parents believed that 14 of 31 (45.2%) siblings had school difficulties related to the ill child, such as increased anxiety or stress at school, lack of attention from teachers, and changes in behaviour as a result of increased carer responsibilities. Parents identified increased absenteeism due to the ill child's hospitalisation and the impact of parent absences on sibling school functioning. Parents described general and psychological support from the school, and the importance of monitoring the sibling at school and focusing on their unique needs. Overall, our findings suggest the need for a school-based sibling support model that combines psycho-education for siblings and school personnel, individualised sibling psychological support, and shared school and parent responsibility in normalising the sibling experience and providing consistent support.

Objectives: This study examines the cost-effectiveness of the OPTI-SCRIPT intervention on potentially inappropriate prescribing in primary care.

Methods: Economic evaluation, using incremental cost-effectiveness and cost utility analyses, conducted alongside a cluster randomized controlled trial of twenty-one general practices and 196 patients, to compare a multifaceted intervention with usual practice in primary care in Ireland. Potentially inappropriate prescriptions (PIPs) were determined by a pharmacist. Incremental costs, PIPs, and quality-adjusted life-years (QALYs) at 12-month follow-up were estimated using multilevel regression. Uncertainty was explored using cost-effectiveness acceptability curves.

Results: The intervention was associated with a nonsignificant mean cost increase of €407 (95 percent CIs, −357–1170), a significant mean reduction in PIPs of 0.379 (95 percent CI, 0.092–0.666), and a nonsignificant mean increase in QALYs of 0.013 (95 percent CIs, −0.016–0.042). The incremental cost per PIP avoided was €1,269 (95 percent CI, −1400–6302) and the incremental cost per QALY gained was €30,535 (95 percent CI, −334,846–289,498). The probability of the intervention being cost-effective was 0.602 at a threshold value of €45,000 per QALY gained and was at least 0.845 at threshold values of €2,500 per PIP avoided and higher.

Conclusions: While the OPTI-SCRIPT intervention was effective in reducing potentially inappropriate prescribing in primary care in Ireland, our findings highlight the uncertainty with respect to its cost-effectiveness. Further studies are required to explore the health and economic implications of interventions targeting potentially inappropriate prescribing.