The Quran contains numerous references to evil and some of these indicate that the responsibility of some instances of evil, which I call self-inflicted evil, lies with human beings rather than God. This idea of evil leads to an exploration of two interconnected issues in philosophical and theological discussions, moral responsibility and desert, along with the related tension between freedom of action and divine determinism. The article delves into this tension as it appears from the Quran and prevailing standpoints in Islamic theology. I propose that the tension between freedom of action and divine determinism resists a satisfactory reconciliation, which ultimately affects the plausibility of the idea of evil as self-inflicted. I further propose that embracing the contradictions arising from verses expressing freedom and responsibility, on the one hand, and those indicating divine determinism, on the other, could be a viable approach for the theologian.