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5 results

  • 36B - There Is Value in Examining Sperm DNA Fragmentation

  • from Section VI - Male-factor Infertility
  • Edited by Roy Homburg, Adam H. Balen, Robert F. Casper
  • Book: 50 Big Debates in Reproductive Medicine
  • Published online: 25 November 2021
  • Print publication: 16 December 2021, pp 186-188

  • Summary

    One of the contemporary challenges in treating infertility is to identify those couples that will likely fail to conceive naturally or after assisted reproduction and will require more extensive interventions to achieve conception. The conventional sperm parameters (sperm concentration, motility, and morphology) provide us with information on the functionality of the seminiferous tubules and the reproductive tract. However, a major drawback of the semen analysis is that conventional sperm parameters are crude indicators of male fertility potential and the reference ranges for these parameters were set based on a population of fertile couples who succeeded in achieving a natural conception [1]. Moreover, these same parameters are not useful in predicting reproductive outcomes with assisted reproductive technologies. As such, there is a real need to identify markers that can accurately assess male fertility potential and help predict reproductive outcomes with assisted reproductive technologies

  • Chapter 11 - Evaluation of sperm function

  • Edited by Larry I. Lipshultz, Stuart S. Howards, University of Virginia, Craig S. Niederberger, University of Illinois, Chicago
  • Book: Infertility in the Male
  • Published online: 19 May 2010
  • Print publication: 24 September 2009, pp 177-198

  • Summary

    The Sertoli cell is implicated centrally in spermatogenesis, organogenesis, male phenotypic development, and the hypothalamic-pituitary-gonadal axis. The cytoskeletal architecture of the Sertoli cell, as in many other cells, consists of actin filaments, intermediate filaments, and microtubules. The interaction of adjoining Sertoli cells with each other and with the basement membrane is crucially important to the function of the Sertoli cell: tight junctions and adherens junctions between Sertoli cells allow for the creation of an immunologically privileged space within the seminiferous tubule. This barrier, created by Sertoli cells and the basement membrane, is known as the blood-testis barrier. This chapter provides a brief discussion spermiogenesis and spermiation. Sertoli cells in adult mammals exist as a terminally differentiated, postmitotic population. Regulation of the Sertoli cell in its function as "nurse cell" for developing spermatogenic cells is obviously multifaceted and complex.