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Migraine headache is an extremely common and temporarily disabling headache disorder. Most studies on migraine prevalence have reported variation by age and gender. Prevalence is generally highest between the ages of 25 and 55, often with a peak in the late 30s and early 40s. Migraine was once considered to be a disease of the affluent. The American Migraine Study showed that migraine prevalence was lower in African-Americans than Asians. Familial aggregation of migraine has long been recognized and genetic studies have generally supported a role for both genetic and environmental risk factors in the etiology of migraine. The heterogeneity of familial hemiplegic migraine (FHM) underscores the likely heterogeneity of the more common types of migraine. Diagnosis of migraine is complicated by the episodic and heterogeneous nature of the illness. Population-based studies demonstrate that migraine is comorbid with depression, anxiety disorders, and manic depressive illness as well as epilepsy.
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