To send content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about sending content to .
To send content items to your Kindle, first ensure email@example.com
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about sending to your Kindle.
Note you can select to send to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
Kleine-Levin syndrome (KLS) is a rare neurological disorder primarily affecting young subjects. The first episode usually begins within a few hours, with patients becoming extremely tired, generally after an identifiable triggering event, such as a banal infection in most cases, alcohol intake, or a head trauma. The symptomatic periods involve hypersomnia, and cognitive, behavioral and psychological problems, and last from two days to several weeks. The most difficult differential diagnoses are psychiatric disorders (psychosis and depression), hence many patients are sent to the psychiatric department before the diagnosis of KLS is made. Recent methods of investigation such as SPECT indicate that the brain dysfunction could be larger than expected, and would encompass both cortical and subcortical (and especially thalamus and hypothalamus) areas. This general picture and the fluctuating symptoms in KLS are consistent with the possibility of an autoimmune mediation of the disorder.