White kidney bean extract (WKBE) is a nutraceutical often advocated as an anti-obesity agent. The main proposed mechanism for these effects is alpha-amylase inhibition, thereby slowing carbohydrate digestion and absorption. Thus, it is possible that WKBE could impact the gut microbiota and modulate gut health. We investigated the effects of supplementing 20 healthy adults with WKBE for 1 week in a randomised, placebo-controlled crossover trial on the composition of the gut microbiota, gastrointestinal (GI) inflammation (faecal calprotectin), GI symptoms, and stool habits. We conducted in vitro experiments and used a gut model system to explore potential inhibition of alpha-amylase. We gained qualitative insight into participant experiences of using WKBE via focus groups. WKBE supplementation decreased the relative abundance of Bacteroidetes and increased that of Firmicutes, however, there were no significant differences in post-intervention gut microbiota measurements between the WKBE and control. There were no significant effects on GI inflammation or symptoms related to constipation, or stool consistency or frequency. Our in vitro and gut model system analyses showed no effects of WKBE on alpha-amylase activity. Our findings suggest that WKBE may modulate the gut microbiota in healthy adults, however, the underlying mechanism is unlikely due to active site inhibition of alpha-amylase.

To extend the molecular gas measurements to typical L* star-forming galaxies (SFGs) at z ∼ 1.5 − 3, we have observed CO emission for five strongly-lensed galaxies selected from the Herschel Lensing Survey. The combined sample of our L* SFGs with CO-detected SFGs at z >1 from the literature shows a large spread in star formation efficiency (SFE). We find that this spread in SFE is due to variations of several physical parameters, primarily the specific star formation rate, but also stellar mass and redshift. An increase of the molecular gas fraction (fgas) is observed from z ∼ 0.2 to z ∼ 1.2, followed by a quasi non-evolution toward higher redshifts, as found in earlier studies. We provide the first measure of fgas of z >1 SFGs at the low-stellar mass end between 109.4 < M∗/M⊙ < 109.9, which shows a clear fgas upturn.

We present near-infrared spectra of young radio quasars selected by cross-correlating the Wide-field Infrared Survey Explorer (WISE) all-sky survey catalog with the radio catalog [Faint Images of the Radio Sky at Twenty cm (FIRST) and NRAO VLA Sky Survey (NVSS)]. The objects have typical redshifts of z ≈ 2 and [O III] luminosities of 107 erg s−1 comparable to those of luminous quasars. The observed flux ratios of narrow emission lines indicate that these objects appear to be powered by active galactic nuclei. The [O III] line is broad, with full width at half maximum ~1300 to 2100 km s−1, significantly larger than that of ordinary quasars. These large line widths might be explained by jet-induced outflows.

Ultra-luminous infrared galaxies (LIR > 1012 L⊙) are locally rare, but appear to dominate the co-moving energy density at higher redshifts (z>2). Many of these are optically-faint, dust-obscured galaxies that have been identified by the detection of their thermal dust emission at sub-mm wavelengths. Multi-wavelength spectroscopic follow-up observations of these sub-mm galaxies (SMGs) have shown that they are massive (Mstellar ~ 1011 M⊙) objects undergoing intense star-formation (SFRs ~ 102−103 M⊙ yr−1) with a mean redshift of z ~ 2, coinciding with the epoch of peak quasar activity. The large fraction of AGNs in SMGs and the derived SMBH masses (M• < 108 M⊙) in these galaxies suggest that the submm phase may play an important role in the rapid growth of SMBHs. When both AGN and star-formation activity are present, long-slit spectroscopic techniques face difficulties in disentangling their contributions and may result in SFR and mass overestimates. We present an integral field view of the Hα emission in a sample of 3 SMGs at z~1.4–2.4 with the IFU instrument OSIRIS on Keck. Designed to be used with Laser Guide Star Adaptive Optics, OSIRIS allows a spatial resolution of up to 10× higher than what has been possible in previous seeing-limited studies of the ionized gas in these galaxies. Our main results are the following: (1) We detect multiple galactic-scale sub-components: the compact, broad Hα emission (FWHM >1000 km s−1) likely associated with an AGN, the more extended narrow-line Hα emission (FWHM ≲500 km s−1) of star-forming regions; the latter are dominated by multiple 1–2 kpc sized Hα-bright clumps, each contributing 1-25% of the total clump-integrated Hα emission. (2) We derive clump dynamical masses ~1–10×109M⊙, 1–2 orders of magnitude larger than the kpc-scaled stellar clumps uncovered in optically-selected z ~ 2 star-forming galaxies. (3) We determine high star-formation rate surface densities (ΣSFR~1–50 M⊙yr−1 kpc−2, after extinction correction), similar to local starbursts and luminous infrared galaxies. In contrast to these local environments, SMGs undergo such intense activity on significantly larger spatial scales as revealed by extended Hα emission over 4–16 kpc. (4) We find no evidence of ordered global motion as it would be found in a disk, but rather large velocity offsets (~ few × 100 km s−1) between the distinct stellar clumps. The merger interpretation is likely the most accurate scenario for the SMGs in our sample. However, the final test of whether an underlying disk structure is present will come from studies of the cold gas at the high spatial resolutions possible with ALMA.

We refer the reader to Menéndez-Delmestre et al. (2012) for more details.

Observations made using COBE, SCUBA, ISO and MAMBO have provided a reasonable working knowledge of both the intensity of the submm and far-infrared background radiation and the source counts of luminous high-redshift dusty galaxies. However, because there are uncertainties in the background intensity determinations, the samples of detected galaxies are small, and most importantly, their redshift distributions are very incomplete, details of the evolution of dusty galaxies remain unresolved. The next steps forward in the field will be the launches of SIRTF and ASTRO-F, the commissioning of SOFIA and new, more capable ground-based mm/submm-wave cameras - BOLOCAM, SHARC-II and SCUBA-II - the use of ultra-long duration balloon experiments, such as BLAST, the construction of ALMA and the arrival of FIRST, and ultimately the advent of space-borne far-infrared interferometers, such as SPECS. There are also exciting prospects for direct mm/submm-wave CO-line redshift surveys using wide-band spectrographs. Using these new facilities, the number of high-redshift dusty galaxies known will be increased dramatically. Spectroscopy using SIRTF, SOFIA and FIRST will probe the astrophysical processes within these sources in detail, hopefully addressing the open question of the fraction of the counts and background radiation that is generated by the formation of high-mass stars and by active galactic nuclei (AGNs). The spatial and spectral structure of distant dusty galaxies will finally be resolved in detail using ALMA and SPECS.