To send content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about sending content to .
To send content items to your Kindle, first ensure firstname.lastname@example.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about sending to your Kindle.
Note you can select to send to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
Schizophrenia and bipolar disorder are severe mental disorders with
overlapping genetic and clinical characteristics, including cognitive
impairments. An important question is whether these disorders also have
overlapping neuronal deficits.
To determine whether large-scale brain networks associated with working
memory, as measured with functional magnetic resonance imaging (fMRI),
are the same in both schizophrenia and bipolar disorder, and how they
differ from those in healthy individuals.
Patients with schizophrenia (n = 100) and bipolar
disorder (n = 100) and a healthy control group
(n = 100) performed a 2-back working memory task
while fMRI data were acquired. The imaging data were analysed using
independent component analysis to extract large-scale networks of
Similar working memory networks were activated in all groups. However, in
three out of nine networks related to the experimental task there was a
graded response difference in fMRI signal amplitudes, where patients with
schizophrenia showed greater activation than those with bipolar disorder,
who in turn showed more activation than healthy controls. Secondary
analysis of the patient groups showed that these activation patterns were
associated with history of psychosis and current elevated mood in bipolar
The same brain networks were related to working memory in schizophrenia,
bipolar disorder and controls. However, some key networks showed a graded
hyperactivation in the two patient groups, in line with a continuum of
neuronal abnormalities across psychotic disorders.
Email your librarian or administrator to recommend adding this to your organisation's collection.