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This chapter explores the essential features of embryo transfer (ET) catheters that may have an impact on the success of in vitro fertilization (IVF) in an evidence-based approach. ET catheters can be subdivided mainly on the basis of the material they are made of and whether they are equipped with, or without, an introducing cannula that facilitates the transfer procedure. Despite the wide variations in the design of ET catheters, the main features that have been studied and found to have a possible influence on the success of ET procedure include flexibility, with or without outer sheath, and echodensity. A more recent systematic review and meta-analysis comparing soft catheters with hard (TDT) catheters demonstrated an increased chance of clinical pregnancy when soft ET catheters were used. The use of ultrasound guidance to facilitate ET has proven useful in women with a previously difficult transfer.