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Hysterosalpingography allowed gynecologists and infertility specialists to study the uterine cavity, shape, and any abnormalities that could result from either congenital problems or acquired disease processes. Irregular uterine bleeding is not an uncommon phenomenon during reproductive period. Many of these cases are dysfunctional uterine bleeding that require endocrine evaluation as well as hematologic studies. Salpingography identifies a normal fallopian tube lumen or abnormalities related to iatrogenic factors such as tubal sterilization or pathology as a result of infection and various kinds of obstructive disease. Various pathological conditions have been identified in the isthmic portion of the fallopian tube with the use of hysterosalpingography. One of these conditions is salpingitis isthmica nodosa. Fallopian tube disease is the single most common cause of infertility and women routinely undergo hysterosalpingography in the course of the infertility work-up to evaluate this factor.