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Excavation at the site of Bhagatrav yielded four layers of cultural deposits: the lowermost being the Sorath Harappan, the upper two are medieval, and layer three caps the Sorath Harappan layer. A horn-deity painted dish was found in a stratified context at the lowest level. The medieval deposit includes turquoise glazed and celadon wares, followed by an abundance of Monochrome Glazed Ware, which is otherwise known as Khambhat ware. The date of the Sorath Harappan layer of the site, the time and space of the horn-deity motif in the Harappan world, and the date of Khambhat ware have long been subjects of discussion. With the help of a series of absolute dating (radiocarbon and luminescence), this paper attempts to place the site, horn-deity motif, and the Khambhat ware in the cultural chronology of Gujarat.
To determine if systemic administration of low-molecular-weight heparin impacts venous compromise in loco-regional flap reconstruction for head and neck subsites.
Methods
This prospective study was conducted on patients who had developed features of venous compromise of the flap. The case group received low-molecular-weight heparin (dalteparin).
Results
Of the 73 patients who developed venous congestion, low-molecular-weight heparin was administered in 47 patients. In the low-molecular-weight heparin subset, 23 patients had either reversal or non-progression of venous compromise (48.9 per cent). Of the patients who had no response to low-molecular-weight heparin rescue, complete necrosis was seen in 4 and partial flap necrosis was observed in 19. The corresponding numbers in the control group were 13 and 12, respectively (odds ratio 23.9, p = 0.002). Additionally, the low-molecular-weight heparin arm had a lower incidence of partial or complete flap necrosis (p = 0.002).
Conclusion
Low-molecular-weight heparin salvage, when instituted early, is likely to result in a significant reduction in flap-related morbidity.
The present study uses Galinstan as a test fluid to investigate the shock-induced atomisation of a liquid metal droplet in a high-Weber-number regime $(We \sim 400\unicode{x2013}8000)$. Atomisation dynamics is examined for three test environments: oxidizing (Galinstan–air), inert (Galinstan–nitrogen) and conventional fluids (deionised water–air). Due to the readily oxidizing nature of liquid metals, their atomisation in an industrial scale system is generally carried out in inert atmosphere conditions. However, no previous study has considered gas-induced secondary atomisation of liquid metals in inert conditions. Due to experimental challenges associated with molten metals, laboratory scale models are generally tested for conventional fluids like deionised water, liquid fuels, etc. The translation of results obtained from conventional fluid to liquid metal atomisation is rarely explored. Here a direct multiscale spatial and temporal comparison is provided between the atomisation dynamics of conventional fluid and liquid metals under oxidizing and inert conditions. The liquid metal droplet undergoes breakup through the shear-induced entrainment mode for the studied range of Weber number values. The prevailing mechanism is explained based on the relative dominance of droplet deformation and Kelvin–Helmholtz wave formation. The study provides quantitative and qualitative similarities for the three test cases and explains the differences in morphology of fragmenting secondary droplets in the oxidizing test case (Galinstan–air) due to rapid oxidation of the fragmenting ligaments. A phenomenological framework is postulated for predicting the morphology of secondary droplets. The formation of flake-like secondary droplets in the Galinstan air test case is based on the oxidation rate of liquid metals and the properties of the oxide layer formed on the atomizing ligament surface.
Silicic magmatism, minor overall in the ∼65.5 Ma Deccan Traps continental flood basalt (CFB) province of India, was widespread in the Saurashtra region. We describe the physical volcanology of silicic volcanics and dykes exposed around Rajula–Savarkundla–Gariyadhar–Talaja towns in southeastern Saurashtra. The silicic volcanics conformably overlie basaltic lavas, suggesting rapid subaerial volcanism, and the sequence shows gentle tectonic dips (∼15°) towards the Arabian Sea. Rhyolites and dacites with preserved thicknesses of tens of metres show intense internal rheomorphic deformation, and a dacite shows a well-formed basal autobreccia. The rheomorphic rhyolites, and vitrophyres which often underlie them, lack vitroclasts (glass shards and pumice clasts). They have very similar mineral assemblages (quartz and alkali feldspar phenocrysts, and crystal cargoes dominated by calcic plagioclase and clinopyroxene or orthopyroxene, sometimes with olivine). The rheomorphic units are thus flood rhyolite and dacite lavas, apparently common in the northern-northwestern Deccan, and the vitrophyres their basal chilled parts. Tuffs (including crystal-vitric Plinian fallout ash) and eutaxitic ignimbrites formed from pyroclastic density currents; one tuff contains extraordinary numbers of lithophysae. Ridges of rhyolitic tuff breccias with pervasive secondary silicification and ferruginization represent pyroclastic eruptive fissures. The area thus records large-scale effusive and explosive silicic eruptions. Mafic and silicic dykes intrude the basaltic lavas and rarely the silicic volcanics. Mafic enclaves in several silicic dykes and some volcanics indicate magma mingling as a common phenomenon. The seaward-dipping volcanic units define a regional-scale flexure comparable to coastal flexures in CFB provinces worldwide, suggesting extensive block-faulting of this classical volcanic rifted margin.
Droplet atomization through aerobreakup is omnipresent in various natural and industrial processes. Atomization of Newtonian droplets is a well-studied area; however, non-Newtonian droplets have received less attention despite their being frequently encountered. By subjecting polymeric droplets of different concentrations to the induced airflow behind a moving shock wave, we explore the role of elasticity in modulating the aerobreakup of viscoelastic droplets. Three distinct modes of aerobreakup are identified for a wide range of Weber number $({\sim }10^2\unicode{x2013}10^4)$ and elasticity number $({\sim }10^{-4}\unicode{x2013}10^2)$ variation: these modes are vibrational, shear-induced entrainment and catastrophic breakup modes. Each mode is described as a three-stage process. Stage I is droplet deformation, stage II is the appearance and growth of hydrodynamic instabilities and stage III is the evolution of liquid mass morphology. It is observed that elasticity plays an insignificant role in the first two stages but a dominant role in the final stage. The results are described with the support of adequate mathematical analysis.
We investigate the interaction of an aqueous polymeric droplet with a tuneable continuous laser in an acoustically levitated environment. The effect of laser irradiation intensity and polymeric concentration on various spatio-temporal parameters is unearthed using high-speed shadowgraphy and theoretical scaling analysis. We observe four temporal phases: droplet evaporation, vapour bubble growth followed by membrane inflation, bubble/membrane rupture through hole nucleation and droplet breakup. During the initial droplet evaporation phase, concentration build-up at the droplet surface beyond a critical limit leads to the formation of a skin layer. It is revealed that, at a given location inside the droplet, hot spots occur, and the maximum temperature at the hot spots scales linearly with irradiation intensity until a bubble nucleates. The low-intensity laser interaction leads to symmetric membrane inflation that eventually forms holes at droplet poles and cracks on the shell surface. On the contrary, high intensity causes early bubble nucleation followed by asymmetric membrane inflation that eventually ruptures through multiple hole formation. Furthermore, the growth and rupture of the membrane is followed by a catastrophic breakup of the droplet. Two dominant atomization modes are reported at significantly high irradiation intensities: stable sheet collapse and unstable sheet breakup. The evolution of droplets into a stable/unstable sheet follows universally observed ligament and hole dynamics. A regime map is shown to describe the influence of polymer concentration and irradiation intensity on the strength and mode of droplet atomization.
Megalithic cultures of central India provide important links between the southern Neolithic-Chalcolithic cultures and the early Historical period (∼500 BC to ∼AD 700) and reveal knowledge of ancient traditions of early inhabitants. Scientific dating of these Megalithic burial sites is a challenging task due to scarcity of dateable material and alterations. Here, we present multiple accelerator mass spectrometry radiocarbon (AMS 14C) dates from equine tooth-enamel and organic food remains recovered from pots from Megalithic burials of the Vidarbha region. Using δ13CTOC and δ15N values of organic food remains recovered from pots, we deduced past-diet (palaeo-vegetation) that indicates C4 type of vegetation and thus arid climate during life-spans of these burials. We also analyzed stable δ13C and δ18O isotopes of equine tooth-enamel to investigate hydro-climatic conditions of Maharashtra (Vidarbha region). A total of 10 AMS 14C dates of tooth enamel provide a time range of AD 250–874 for two Megalithic burials. Two AMS 14C dates of organic food remains recovered from pots corroborated aforementioned time-range. The average δ13C and δ18O of equine tooth-enamel samples were −5.3 ± 2.1‰ and −2.9 ± 0.8‰, respectively, both significantly enriched compared to their modern counterparts (−13.7‰ ± 0.7 and −4.3‰ ± 1.1), indicating intense arid conditions in the past.
To see the neuromodulatory effects of adjunctive HD-tDCS on white matter connectivity by using Diffusion Tensor Imaging (DTI) in schizophrenia patients with Auditory Verbal Hallucinations (AVH)
Methods
This was a randomized, double blind, sham controlled study. 40 patients of schizophrenia with prominent auditory verbal hallucinations and 10 age sex matched healthy controls were selected. The patients were randomly assigned to 2 groups and were given active or sham adjunctive HDtDCS (Active Treatment = 10 sessions of 2 mA current applied for 20 minutes, twice daily for 5 days, at left temporo-parietal Junction (TPJ); Sham treatment = 10 sessions of 1 mA current, twice daily for 5 days was applied for 30 sec at left TPJ). Fractional anisotropy of left arcuate fasciculus by Diffusion tensor imaging was assessed and severity of schizophrenia symptoms and auditory hallucinations were rated on PANSS and PSYRATS-AH at baseline, after 1st week (i.e. end of HDtDCS sessions) and 4 weeks after the end of the HDtDCS sessions). Patients received stable dose of antipsychotics for the total study duration (equivalent to or more than 400 mg of chlorpromazine) to eliminate confounding bias. Fractional anisotropy of left arcuate fasciculus by Diffusion tensor imaging was assessed in healthy controls. DTI data were analysed by DSI Studio software. Statistical analysis was done by SPSS version 25.
Results
1. Both the patient groups were comparable with regard to socio-demographic variables and baseline clinical variables.
2. There was no significant difference in the values of Fractional Anisotropy in Left Arcuate Fasciculus among the patients and healthy controls at baseline.
3. The group receiving active adjunctive HDtDCS, showed significant improvement in the frequency domain of AVH over time, in time*group comparison by repeat measure ANOVA with Mauchly's test of sphericity and Greenhouse-Geisser correction [p = 0.011 and partial eta square = 0.129].
4. There was no significant difference in change in the Fractional anisotropy of the left arcuate fasciculus noted between the groups over time.
5. Application of HDtDCS was not associated with significant side effects, minor itching and mild burning sensation being the only reported side effects
Conclusion
Adjunctive active HD-tDCS to the left temporo-parietal junction showed a statistically significant improvement in frequency of auditory verbal hallucinations (AVH) in schizophrenia patients, when compared to sham stimulation.
For a locally compact metrisable group G, we study the action of
${\rm Aut}(G)$
on
${\rm Sub}_G$
, the set of closed subgroups of G endowed with the Chabauty topology. Given an automorphism T of G, we relate the distality of the T-action on
${\rm Sub}_G$
with that of the T-action on G under a certain condition. If G is a connected Lie group, we characterise the distality of the T-action on
${\rm Sub}_G$
in terms of compactness of the closed subgroup generated by T in
${\rm Aut}(G)$
under certain conditions on the center of G or on T as follows: G has no compact central subgroup of positive dimension or T is unipotent or T is contained in the connected component of the identity in
${\rm Aut}(G)$
. Moreover, we also show that a connected Lie group G acts distally on
${\rm Sub}_G$
if and only if G is either compact or it is isomorphic to a direct product of a compact group and a vector group. All the results on the Lie groups mentioned above hold for the action on
${\rm Sub}^a_G$
, a subset of
${\rm Sub}_G$
consisting of closed abelian subgroups of G.
The multiscale dynamics of a shock–droplet interaction is crucial in understanding the atomisation of droplets due to external airflow. The interaction phenomena are classified into wave dynamics (stage I) and droplet breakup dynamics (stage II). Stage I involves the formation of different wave structures after an incident shock impacts the droplet surface. These waves momentarily change the droplet's ambient conditions, while in later times they are mainly influenced by shock-induced airflow. Stage II involves induced airflow interaction with the droplet that leads to its deformation and breakup. Primarily, two modes of droplet breakup, i.e. shear-induced entrainment and Rayleigh–Taylor piercing (RTP) (based on the modes of surface instabilities) were observed for the studied range of Weber numbers $(We\sim 30\text{--}15\,000)$. A criterion for the transition between two breakup modes is obtained, which successfully explains the observation of RTP mode of droplet breakup at high Weber numbers $(We\sim 800)$. For $We > 1000$, the breakup dynamics is governed by the shear-induced surface waves. After formation, the Kelvin–Helmholtz waves travel on the droplet surface and merge to form a liquid sheet near the droplet equator. Henceforth, the liquid sheet undergoes breakup processes via nucleation of several holes. The breakup process is recurrent until the complete droplet disintegrates or external drag acting on the droplet is insufficient for further disintegration. At lower Weber numbers, the droplet undergoes complete deformation like a flattened disk, and a multibag mode of breakup based on RTP is observed.
Using Internet search volume for lottery to capture gambling sentiment shifts, we show that when the overall gambling sentiment is strong, investor demand for lottery stocks increases, these stocks earn positive short-run abnormal returns, managers are more likely to split stocks to cater to the increased demand for low-priced lottery stocks, and initial public offerings (IPOs) earn higher first day returns. Further, the sentiment-return relation is stronger among low institutional ownership firms, headquartered in regions where gambling is more acceptable and local bias is stronger. These results suggest that gambling sentiment has a spillover effect on the stock market.
One of the most challenging problems in biomedicine and genomics is the identification of disease biomarkers. In this study, proteomics data from seven major cancers were used to construct two weighted protein–protein interaction networks, i.e., one for the normal and another for the cancer conditions. We developed rigorous, yet mathematically simple, methodology based on the degeneracy at –1 eigenvalues to identify structural symmetry or motif structures in network. Utilizing eigenvectors corresponding to degenerate eigenvalues in the weighted adjacency matrix, we identified structural symmetry in underlying weighted protein–protein interaction networks constructed using seven cancer data. Functional assessment of proteins forming these structural symmetry exhibited the property of cancer hallmarks. Survival analysis refined further this protein list proposing BMI, MAPK11, DDIT4, CDKN2A, and FYN as putative multicancer biomarkers. The combined framework of networks and spectral graph theory developed here can be applied to identify symmetrical patterns in other disease networks to predict proteins as potential disease biomarkers.
Research on informed choice in modern contraceptive method acceptance by young married women is pertinent in the broader context of individual freedom and reproductive rights, especially in countries where women continue to have limited control over their reproductive and contraceptive choices. This study in India asked: (1) is young married women’s acceptance of specific modern contraceptive methods an informed choice? and (2) what are the enablers and barriers to informed choice? The study used data for currently married women aged 15–24 (N = 20,752) from the fourth round of the National Family Health Survey (NFHS-4) conducted in 2015–16. A Method Information Index (MII) was calculated as a measure of informed choice from the percentage of users who responded ‘yes’ to all three questions on: whether they were informed about methods other than the one they received, told about the method-specific side-effects, and advised what to do if they experienced side-effects. Binary logistic regression analysis was carried out to examine the adjusted effect of factors associated with the MII separately for female sterilization, the intrauterine device and the oral contraceptive pill, and a combined MII including all three methods plus injectables. One-fifth of the study women used any modern contraceptive method at the time of survey, of which only 36% had fully informed choice. The likelihood of being informed about the methods was significantly higher among those using the oral contraceptive pill (OR: 1.75, CI 1.58–1.94), IUD (OR: 2.23, CI 1.97–2.52) and injectables (OR: 1.37, CI 0.97–1.94) compared with those who were sterilized. Informed choice varied by region and the socioeconomic profile of the users. Inadequately informed choice violates the reproductive rights of young women and might result in higher post-use health problems, discontinuation of and unmet need for contraceptives, unintended pregnancies, induced abortions and regret, adversely affecting women’s health. Training of health/family planning workers in India about the importance of reproductive rights is urgently required to enhance informed contraceptive choice and improve the health of young married women.
Consider the action of $\operatorname{GL}(n,\mathbb{Q}_{p})$ on the $p$-adic unit sphere ${\mathcal{S}}_{n}$ arising from the linear action on $\mathbb{Q}_{p}^{n}\setminus \{0\}$. We show that for the action of a semigroup $\mathfrak{S}$ of $\operatorname{GL}(n,\mathbb{Q}_{p})$ on ${\mathcal{S}}_{n}$, the following are equivalent: (1) $\mathfrak{S}$ acts distally on ${\mathcal{S}}_{n}$; (2) the closure of the image of $\mathfrak{S}$ in $\operatorname{PGL}(n,\mathbb{Q}_{p})$ is a compact group. On ${\mathcal{S}}_{n}$, we consider the ‘affine’ maps $\overline{T}_{a}$ corresponding to $T$ in $\operatorname{GL}(n,\mathbb{Q}_{p})$ and a nonzero $a$ in $\mathbb{Q}_{p}^{n}$ satisfying $\Vert T^{-1}(a)\Vert _{p}<1$. We show that there exists a compact open subgroup $V$, which depends on $T$, such that $\overline{T}_{a}$ is distal for every nonzero $a\in V$ if and only if $T$ acts distally on ${\mathcal{S}}_{n}$. The dynamics of ‘affine’ maps on $p$-adic unit spheres is quite different from that on the real unit spheres.
This study shows that correlated trading by gambling-motivated investors generates excess return comovement among stocks with lottery features. Lottery-like stocks comove strongly with one another, and this return comovement is strongest among lottery stocks located in regions where investors exhibit stronger gambling propensity. Looking directly at investor trades, we find that investors with a greater propensity to gamble trade lottery-like stocks more actively and that those trades are more strongly correlated. Finally, we demonstrate that time variation in general gambling enthusiasm and income shocks from fluctuating economic conditions induce a systematic component in investors’ demand for lottery-like stocks.
Structural characterization, quantitative phase analysis, and morphological behavior of biomineralized deposits in human pancreas [pancreatic stones (PSs)] have been carried out using infrared (IR)-spectroscopy, scanning electron microscopy (SEM), powder x-ray diffraction, and thermogravimetry - differential scanning calorimetry (TG–DSC). The fourier transform infrared (FT-IR) spectra indicated that the primary composition of PSs was calcium carbonate. An x-ray powder diffraction phase quantification using the Rietveld method revealed that five of the pancreatic calculi were composed exclusively of calcite (CAL) and the remaining four contained small amounts of vaterite and aragonite in addition to the CAL phase. The crystallite size of CAL in the PSs study varied between 104(6) and 181(2) nm. The SEM images of pancreatic calculi showed a variety of crystal morphologies for biogenic CAL crystallites such as, thin plates, spherulites, prisms, and cylindrical laths. Thermogravimetric analysis of PS1 reveals that biogenic CAL is stable up to 910 K, above which temperature CAL transforms into calcium oxide.
This study examines whether state-level economic conditions affect the liquidity of local firms. We find that liquidity levels of local stocks are higher (lower) when the local economy has performed well (poorly). This relation is stronger when local financing constraints are more binding, the local information environment is more opaque, and local institutional ownership levels and trading intensity are higher. Overall the evidence supports the notion that the geographical segmentation of U.S. capital markets generates predictable patterns in local liquidity.
The major objectives of this study were to evaluate the existing pediatrics health care service provisions and utilizations of the public polyclinics in Barbados. Furthermore, the aim was to assess if the existing manpower resources were adequate.
Background
Barbados has a mixed health care system consisting of both a socialized and a private health care system. The Ministry of Health commissioned a needs assessment survey of the pediatrics primary health care at the public polyclinics.
Methods
Primary data were collected through interviews with the public primary health care providers. Secondary data were collected from the Barbados Census Data and Ministry of Health statistics. Data were analyzed to assess the pediatrics primary health care service utilization and adequacy of existing resources at the polyclinics.
Findings
In 2012, there were 62 934 visits from children <16 years of age to the public polyclinics in Barbados and this accounted for 39.1% of all visits (both adults and children) to the polyclinics. An overall 16.7% of the visits were from children less than five years old to the Well Child Clinic for immunization and for growth and development monitoring; 32% of all physician consultations at the polyclinics were for children <16 years. Utilization of health services by children at the polyclinics was 5245 visits/month. Given an expected monthly demand for 10 822 visits from children, the polyclinics serve 48.5% of the primary health care demand for children in Barbados.
Conclusions
The public polyclinics play a pivotal role in the pluralistic primary health care system in Barbados. They fulfill nearly half of all the primary care demand and more importantly provides for almost the entire immunization demand, and thereby ensuring high coverage.
The existing resources, if used optimally, would reduce the long consultation time observed in this setting, and thereby increase the capacity considerably.
We demonstrate that personal political preferences of corporate managers influence corporate policies. Specifically, Republican managers who are likely to have conservative personal ideologies adopt and maintain more conservative corporate policies. Those firms have lower levels of corporate debt, lower capital and research and development (R&D) expenditures, less risky investments, but higher profitability. Using the 9/11 terrorist attacks and Sept. 2008 Lehman Brothers bankruptcy as natural experiments, we demonstrate that investment policies of Republican managers became more conservative following these exogenous uncertainty-increasing events. Furthermore, around chief executive officer (CEO) turnovers, including CEO deaths, firm leverage policy becomes more conservative when managerial conservatism increases.