PET imaging is increasingly recognized as an important diagnostic tool to investigate patients with cognitive disturbances of possible neurodegenerative origin. PET with 2-[18F]fluoro-2-deoxy-D-glucose ([18F]FDG), assessing glucose metabolism, provides a measure of neurodegeneration and allows a precise differential diagnosis among the most common neurodegenerative diseases, such as Alzheimer’s disease, frontotemporal dementia or dementia with Lewy bodies. PET tracers specific for the pathological deposits characteristic of different neurodegenerative processes, namely amyloid and tau deposits typical of Alzheimer’s Disease, allow the visualization of these aggregates in vivo. [18F]FDG and amyloid PET imaging have reached a high level of clinical validity and are since 2022 investigations that can be offered to patients in standard clinical care in most of Canada.

This article will briefly review and summarize the current knowledge on these diagnostic tools, their integration into diagnostic algorithms as well as perspectives for future developments.

The boundaries of European integration and especially the relationship between European and German Constitutional Law have occupied the German Constitutional Court—the Bundesverfassungsgericht in Karlsruhe—time and again since its first Solange I Judgment of 1974. Practically all of these decisions—Solange II, Maastricht, Lisbon, and Honeywell to name just a few—have had a major impact not only on the national, but also on the European discourse regarding the future of the European Union. 14 January 2014 now marks the date of another “historic” decision in this sense, which, unsurprisingly, has already led to major discussions not only in Germany, but all over Europe. For the first time ever the Constitutional Court has initiated a referral to the European Court of Justice asking questions about the conformity of some of the highly disputed measures of the ECB taken to fight the crisis with Primary European Law. The reluctance of the Constitutional Court to comply with its duties under the TFEU and to accept the role of the ECJ as the final interpreter of European Law had been criticized for many years, not only after the Lisbon Decision of 2009. However, the Constitutional Court reacted to these critics in its Honeywell Decision of 2010 and, so it seemed, started to redefine its understanding of its relationship with the European judicial system. This redefining process has now found its temporary endpoint with this first referral, which therefore truly stands for a new era in the relationship between the Constitutional Court and the ECJ within the “European Network of Constitutional Courts.”

This article introduces the special issue on climate adaptation and institutions. Economic accounts of climate adaptation have stressed its collective action nature and the limitations of standard economic approaches to the matter. Governance accounts, on their part, have shown that adaptation does not always happen when it is expected. Against this background, institutional economics has the potential to shed light on those societal processes and collective mechanisms leading to and shaping adaptation (or the absence of it). The selection of articles contributing to this special issue shows that climate adaptation can indeed be explored successfully through institutional economics, and that doing so fits well within the institutional economics agenda. Some recommendations for future research are provided at the end.

Smouldering European debt crisis: overall public debt ratio as problem – Haircut as possible solution – Greece’s current creditors: public institutions (Member States and European Central Bank) – Insuring a sound budgetary policy as main goal of Article 125 TFEU – Consequences for a haircut by the Member States – The mandate of the European Central Bank and the prohibition of direct purchases of Member State bonds – Consequences for a haircut by the European Central Bank – Haircut as political question open for democratic debate

Public debt: relevance for funding of modern states – Keynesian revolution – Consequences of the financial crisis in Germany – Introduction of the debt brake and Fiscal Compact – The constitutional debt brake: structure and exceptions of the balanced budget rule, four deficiencies of the debt brake – The Fiscal Compact: historical background and structure of the balanced budget rule – Sufficient implementation of the balanced budget rule in Germany? – Constitutionality of the Fiscal Compact? – Austerity as the wrong answer for solving the current economic problems

We provide an overview of current techniques and typical applications of numerical bifurcation analysis in fluid dynamical problems. Many of these problems are characterized by high-dimensional dynamical systems which undergo transitions as parameters are changed. The computation of the critical conditions associated with these transitions, popularly referred to as ‘tipping points’, is important for understanding the transition mechanisms. We describe the two basic classes of methods of numerical bifurcation analysis, which differ in the explicit or implicit use of the Jacobian matrix of the dynamical system. The numerical challenges involved in both methods arementioned and possible solutions to current bottlenecks are given. To demonstrate that numerical bifurcation techniques are not restricted to relatively low-dimensional dynamical systems, we provide several examples of the application of the modern techniques to a diverse set of fluid mechanical problems.

We designed and produced pure cubic zirconia (ZrO2) ceramic1 coatings by an ion beam assisted deposition (IBAD) with nanostructures comparable to the size of proteins. Our ceramic coatings exhibit high hardness and a zero contact angle with serum. In contrast to hydroxyapatite (HA), nano-engineered zirconia films possess excellent adhesion to all orthopaedic materials. Cell adhesion and proliferation experiments were performed with a bona fide mesenchymal stromal cell line (OMA-AD). Our experimental results indicate that the nano-engineered cubic zirconia is superior in supporting growth, adhesion, and proliferation. Since cell attachment is mediated by adhesive proteins such as fibronectin (FN), to elucidate why cells attach more effectively to our nanostructures, we performed a comparative analysis of adsorption energies of FN fragment using quantum mechanical calculations and Monte Carlo (MC) simulation both on smooth and nanostructured surfaces. We have found that a FN fragment adsorbs significantly stronger on the nanostructured surface than on the smooth surface2.

Hebb's theory of cell assemblies is a precursor of the neural network approach used as an implicit hypothesis by most contemporary neuroscientists. Applying this model to language representation leads to demanding predictions about the organization of semantic categories. Other implications of a Hebbian approach to language representation, however, may prove problematic with respect to both neurolinguistic concepts and the results of neuroimaging studies.