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It is unclear whether olfactory deficits improve after remission in depressed patients. Therefore, we aimed to assess in drug-free patients the olfactory performance of patients with major depressive episodes (MDE) and its change after antidepressant treatment.
Methods
In the DEP-ARREST-CLIN study, 69 drug-free patients with a current MDE in the context of major depressive disorder (MDD) were assessed for their olfactory performances and depression severity, before and after 1 (M1) and 3 (M3) months of venlafaxine antidepressant treatment. They were compared to 32 age- and sex-matched healthy controls (HCs). Olfaction was assessed with a psychophysical test, the Sniffin’ Sticks test (Threshold: T score; Discrimination: D score; Identification: I score; total score: T + D + I = TDI score) and Pleasantness (pleasantness score: p score; neutral score: N score; unpleasantness score: U score).
Results
As compared to HCs, depressed patients had lower TDI olfactory scores [mean (s.d.) 30.0(4.5) v. 33.3(4.2), p < 0.001], T scores [5.6(2.6) v. 7.4(2.6), p < 0.01], p scores [7.5(3.0) v. 9.8(2.8), p < 0.001)] and higher N scores [3.5(2.6) v. 2.1(1.8), p < 0.01]. T, p and N scores at baseline were independent from depression and anhedonia severity. After venlafaxine treatment, significant increases of T scores [M1: 7.0(2.6) and M3: 6.8(3.1), p < 0.01] and p scores [M1: 8.1(3.0) and M3: 8.4(3.3), p < 0.05] were evidenced, in remitters only (T: p < 0.01; P: p < 0.01). Olfaction improvement was mediated by depression improvement.
Conclusions
The olfactory signature of MDE is restored after venlafaxine treatment. This olfaction improvement is mediated by depression improvement.
Mount Oku, in the Northwest Region of Cameroon, is known for its rodent diversity. It is located in an area with a high human population density (up to 400/km2), resulting in intense pressure on natural resources. Threats to biodiversity include overgrazing by cattle and goats in grassland areas and montane forests, firewood harvesting, agriculture, bee keeping, debarking of Prunus trees for medicinal uses, and bushmeat hunting. We used data from interviews with 106 local hunters to provide insights into rodent trapping in Oku village. Trapping took place primarily in closed canopy forest. The majority of hunters (88.8%) set at least 100 traps per week, with a mean of 38 rodents trapped per hunter per week. The two most captured species were the Vulnerable Hartwig's praomys Praomys hartwigi and the Endangered Mount Oku rat Lamottemys okuensis, both of which have declining populations. Rodents were harvested mainly for household consumption and/or local trade, but 65.1% of interviewees also used P. hartwigi for traditional medicine. Our findings suggest that rodent trapping in Oku village requires conservation attention, and that further quantitative studies are needed to assess its sustainability.
In mice, hepatic functions can be greatly affected by dietary trans-10, cis-12-conjugated linoleic acid (CLA). However, this phenomenon has been less documented in hamsters. In the present study, male hamsters were fed two doses of the trans-10, cis-12-CLA (0·5 and 1 %, w/w diet) or linoleic acid (0·5 %) for 6 weeks. The effects on the liver were examined by measuring the expression of thirty-six genes representing key metabolic pathways. CLA-responsive genes and their relationships with physiological outcomes were examined by a multivariate analysis procedure. Compared with control hamsters, those receiving either 0·5 or 1 % CLA exhibited similar fat loss (15–24 %; P ≤ 0·05) and liver enlargement (21–28 %; P ≤ 0·05), with no signs of steatosis. We also observed a dose-dependent increase in the transcription of genes involved in lipid breakdown and lipid harvesting from blood, and in genes related to the oxidative stress and inflammatory responses. These responsive genes varied in parallel with cell membrane lipids (R2 0·31–0·42) and to a lesser extent with liver enlargement (R2 0·22) (all P < 0·05). We conclude that in hamsters, liver enlargement induced by trans-10, cis-12-CLA is accompanied by an increased metabolic potential to process fatty acids from mobilised adipose stores. This elevated metabolic activity, comprised of anabolic pathways and their catabolic counterparts, can trigger inflammation and the oxidant stress defence pathways in a dose-dependent manner. These results provide novel insights into the mechanisms by which trans-10, cis-12-CLA affects pathways related to liver function.
With the spread of angiosperms some lineages of ants, originally ground-dwellers and predators, adapted to arboreal life. Ground-nesting worker ants probably constituted the first case of biotic plant protection through their predatory activity while foraging on plant foliage. Then, ants developed tight evolutionary bonds with plants varying from facultative diffuse relationships to obligatory specific associations, necessary to the survival of both partners. In diffuse relationships plants induce different ant species to patrol their foliage by producing energy-rich food rewards such as extra-floral nectar (EFN) and/or food bodies (FBs) (Dejean et al. 2007, Heil 2008, Heil & McKey 2003). First described by Janzen (1966), myrmecophytes, or plants that provide specialized plant-ants a nesting place in hollow structures called domatia, represent a good example of a strict association as, in return, they are protected from several kinds of enemies, particularly defoliating insects (Heil & McKey 2003, Hölldobler & Wilson 1990).
Fluorochrome marking of the gastropod Concholepas concholepas has shown that the prismatic units of the shell are built by superimposition of isochronic growth layers of about 2 μm. Fluorescent growth marks make it possible to establish the high periodicity of the cyclic biomineralization process at a standard growth rhythm of about 45 layers a day. Sulphated polysaccharides have been identified within the growth layers by using synchrotron radiation, whereas high resolution mapping enables the banding pattern of the mineral phase to be correlated with the layered distribution of polysaccharides. Atomic force microscopy has shown that the layers are made of nanograins densely packed in an organic component.
La topographie de surface est une caractéristique à prendre en considération au même titre que la composition chimique pour décrire la fonctionnalité d'une surface. Cette topographie peut être décrite par des paramètres de rugosité d'amplitude, de fréquence ou hybrides. L'évolution de deux paramètres d'amplitude Ra et Rt en fonction de la longueur d'évaluation est ici étudiée sur un acier inoxydable de type 316L dont la surface est obtenue par polissage pour différents grades de papier. Cette étude montre l'existence de trois régimes en fonction de l'échelle d'observation des valeurs de Ra et Rt. Un premier régime où l'endommagement des surfaces ne comporte pas de loi d'échelle entre les différents grades de papier. Un régime transitoire est aussi identifié et caractérisé par un paramètre d'évaluation appelé Cut-Off qui suit une loi logarithmique en fonction de la taille de grain du papier. Enfin un troisième régime où les paramètres de rugosité suivent une parfaite loi d'échelle prouve que pour ce régime les mécanismes d'endommagement sont identiques à des échelles différentes.
The Montréal area belongs to the St Lawrence Lowlands, a Cambrian Early Ordovician passive margin of the Iapetus Ocean, later covered by Appalachian Middle to Upper Ordovician foreland deposits. A structural and palaeostress analysis has been carried out in order to reconstruct its tectonic evolution. The structural map has been revised with new data. Palaeostresses are reconstructed based on inversion of fault slip data, and these results are independently corroborated by the microstructural study of calcite mechanical twinning. Field relationships are used to establish the relative chronology of fractures and to deduce the motion on regional faults. The reconstructed structural and tectonic evolution brings to light some relationships between structural inheritance and tectonic events that have affected the area since Early Palaeozoic times. An early NW–SE extension is responsible for N040-trending faults along the northern border of the St Lawrence Lowlands, and for N090- and N120-trending faults cross-cutting the Montréal area. This extension is followed by WNW–ESE and NNW compressions, which have induced reverse motion on pre-existing faults and generated strike-slip conjugate faults. Subsequent NE–SW and NNW–SSE-directed extensions have reactivated previous faults with normal to strike-slip motions. A late NE–SW compression is recorded in the Monteregian plutons. Compressions in WNW–ESE and NNW directions are consistent with Appalachian collisional tectonism, but N040- and N090-trending faults cross-cut Appalachian folds and foreland deposits. Although the early NW–SE extension is consistent with the collapse of the Iapetan margin in Early Palaeozoic times, most of the present geometry of the St Lawrence Lowlands could be attributed to Mesozoic tectonism, recorded as nearly N–S-directed extensional events.
Among the gastropods, some muricid shells are composed of an inner aragonitic crossed lamellar layer and a calcitic prismatic outer layer. The analysis of the structure and composition of the two layers of Concholepas shows that the crossed lamellar layer is similar to those of other Mollusc taxa. Sr, Mg and S contents are low in both layers. According to infrared spectrometry, the organic content of the outer calcitic layer is higher than that of the aragonitic crossed lamellar layer. The study of the nanostructure allows for the proposal of a new 3D interpretation of the fine structure of the crossed lamellar layer. The calcitic prismatic layer is compared with the outer calcitic prismatic layer of an archaeogastropod genus: Haliotis.
Data on the pollination biology of neotropical aroids are still scarce and concern only a few species (Beath 1999, Croat 1997, Gibernau et al. 1999, 2000; Mayo et al. 1997 and references cited therein). It appears from these studies that Anthurium, Monstera and Spathiphyllum are on the whole pollinated mainly by bees (but see Kraemer & Schmitt 1999), whereas Dieffenbachia, Homalomena, Syngonium, Philodendron and Xanthosoma are generally beetle-pollinated. Although araceous inflorescences may be visited by several insect taxa (Madison 1979), only a few are the legitimate pollinators for each species (Seres & Ramirez 1995, Valerio 1984, Young 1986).
Radio astronomy in the decameter to centimeter wavelength range is facing new challenges because of man made interferences due to increasing needs in telecommunications. At the Radioastronomy department of Paris Meudon Observatory, we have been working since four years on high dynamic range digital receivers based on Digital Signal Processors (DSP). The first achievement is a digital spectro- polarimeter devoted to spectroscopy of astrophysical radiation in decameter range, now in operation at the Nancay Decameter array. The block diagram of the receiver includes a high dynamic range analogue section followed by a 12 bits analogue to digital converter. The digital part makes use of high power, programmable digital circuits for signal processing, arranged in a dedicated parallel architecture, able to compute in real time the power spectrum and the correlation of the input signals. This receiver was also used, as spectrometer backend, at Nancay decimetric radiotelescope and has performed very well in the presence of very strong interferences. We are presently working on a new digital receiver with broader bandwidth. The objective is 2 × 25 MHz band with at least 60 dB dynamic range. This new receiver will use additional computation power in order to recognise and avoid man made interferences which corrupt the radio astronomical signal. At the Nancay Radioastronomy Observatory, we have started to develop a new digital configurable receiver with 8 times 25 MHz band and ten thousand channels. For low frequency radioastronomy, direct spectrum computation technique is really powerful and offers new capabilities for real time interferences excision. Fig. 1 shows pulsar observations in the presence of interference made with the DSP receiver on the UTR-2 radiotelescope. Fig. 2 shows the effect of satellite interfernce on OH observations made with the Nancay telescope. Fig. 3 shows the block diagram of the DSP system and demonstrates how offline excision of interference in the frequency time-domain enables recovery of the signal. The final spectrum had 960 minutes integration on and off source and took 8045 minutes of procession on a 450 MHz Pentium II.
In the model proposed by Findlay & Walker, the programming of saccadic eye movements is achieved by two parallel processes, one dedicated to the coding of saccade metrics (Where) and the other controlling saccade initiation (When). One outcome of the “winner-take-all” characteristics of the salience map, the main node of the model, is an independence between the metrics and the latency of saccades. We report on some observations, made in the head-unrestrained cat under pathological conditions, of a correlation between accuracy and latency of saccadic gaze shifts. To account for such a correlation, the link between metrics specification (Where) and saccade triggering (When) should be amended in the model.
P.V.D. tungsten films deposited on silicon wafers (covered or not with a P.E.C.V.D. silicon oxide, nitride or oxynitride sublayer) were submitted to bulge and blister tests. The mechanical equilibrium and geometry of the bulged tungsten membranes is compared to various models. From this analysis, values of the residual stresses and the Young's moduli in the films are derived, and found to be consistent with previous values deduced from curvature radius measurements or other mechanical test methods, as functions of the deposition conditions. Decohesion of the films from their substrates is easily observed on the W / SiO2 / Si membranes, and the film / sublayer interfacial fracture energy is estimated about 1 J/m2. This energy increases when the sublayer is changed from SiO2 to silicon oxi-nitride and to nitride. The W / Si membranes show a much stronger adhesion than the abovementioned ones and could not be debonded before bursting.
Films of silicon nitride are widely used in semiconductor technologies for very large scale integration (VLSI), thin film transistor (TFT), and solar cell applications. Current production technologies for silicon nitride use low pressure chemical vapor deposition (LPCVD) at temperatures > 700 °C or plasma enhanced chemical vapor deposition (PECVD) at temperatures below 450 °C. In this report, successful deposition of silicon nitride films by the low temperature thermal atmospheric pressure chemical vapor deposition (APCVD) method is described. Using a novel precursor tetraiodosilane (SiI4), deposition of silicon nitride has been achieved at temperature as low as 400 °C. Data pertaining to the dependence of film properties on deposition temperature are presented, along with a evaluation of the deposition rate, composition, chemical structure, and conformality of the resulting films.
Les quelques réflexions qui suivent sont faites à partir du livre de Pierre Bourdieu, Les Règles de l'art. Genèse et structure du champ littéraire. A partir de : en cela, elles répondent sans doute à l'un des voeux de l'ouvrage qui, dans ses énoncés volontiers programmatiques, tend à susciter des prolongements. A partir de et non pas sur : on ne traitera donc pas ici de son analyse de L'Éducation sentimentale et des débats qu'elle a, à juste titre, provoqués. Ni de ceux qu'a enclenchés le ton polémique exhibé par intervalles dans ce Livre.
We compared anthropometric indices in samples of elderly people aged 65 years and over living in two French areas. The samples were divided into four age-groups (65–69, 70–74, 75–79 and over 80 years). We observed interregional differences in women aged 65–69 years and in men aged 65–74 years. Weight and anthropometric variables related to body fat percentage and to muscle mass showed a decline with age as already reported by others. We established anthropometric percentile values according to sex in pooled subjects when no integrated difference was found. The 50th percentile of arm circumference, muscle arm circumference and triceps skinfold was higher, and the 50th percentile of body mass index was lower than the one reported for the same indices from an elderly Welsh population. Our results show that an interregional difference in anthropometric indices exists in the elderly. The differences which are observed between our results and those reported from a British population emphasize the importance of establishing local values for the elderly population.
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