This is the first report on increasing yield and nutritional content of snake melon (Cucumis melo L. var. flexuosus) by exploiting intraspecific genetic variation of genetically diverse melons. Inbred snake melon ‘Punjab Long melon 1’ (PLM1) was hybridized with five genetically diverse inbred melons: KP 7 (var. momordica), AM 72 (var. acidulus), ‘Arya 1’ (var. chate), 04-02 (var. tibish) and ‘Punjab Wanga’ (unknown botanical variety). The parents and hybrids were evaluated at three locations for nine traits. Hybrids PLM1 × 04-02 and PLM1 × ‘Punjab Wanga’ exhibited significant (P0.05) heterosis for the number of marketable fruits per plant, and ascorbic acid and carotenoid contents of marketable fruits.