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Genome-wide association studies (GWAS) have consistently revealed that a variant of microRNA 137 (MIR137) shows a quite significant association with schizophrenia. Identifying the network of genes regulated by MIR137 could provide insights into the biological processes underlying schizophrenia. In addition, DLPFC functional connectivity, a robust correlate of MIR137, may provide plausible endophenotypes. However, the regulatory role of the MIR137 gene network in the disrupted functional connectivity remains unclear. Here, we tested the effects of the MIR137 regulated genes on the risk for schizophrenia and DLPFC functional connectivity.
To evaluate the additive effects of the MIR137 regulated genes (N = 1274), we calculated a MIR137 polygenic risk score (PRS) for schizophrenia and tested its association with the risk for schizophrenia in the genomic data of a Han Chinese population that included schizophrenia patients (N = 589) and normal controls (N = 575). We then investigated the association between MIR137 PRS and DLPFC functional connectivity in two independent young healthy cohorts (N = 356 and N = 314).
We found that the MIR137 PRS successfully captured the differences in genetic structure between the patients and controls, but the single gene MIR137 did not. We then consistently found that a higher MIR137 PRS was correlated with lower functional connectivities between the DLPFC and both the superior parietal cortex and the inferior temporal cortex in two independent cohorts.
The findings suggested that these two functional connectivities of the DLPFC could be important endophenotypes linking the MIR137-regulated genetic structure to schizophrenia.
Schizophrenia is a complex mental disorder with high heritability and polygenic inheritance. Multimodal neuroimaging studies have also indicated that abnormalities of brain structure and function are a plausible neurobiological characterisation of schizophrenia. However, the polygenic effects of schizophrenia on these imaging endophenotypes have not yet been fully elucidated.
To investigate the effects of polygenic risk for schizophrenia on the brain grey matter volume and functional connectivity, which are disrupted in schizophrenia.
Genomic and neuroimaging data from a large sample of Han Chinese patients with schizophrenia (N = 509) and healthy controls (N = 502) were included in this study. We examined grey matter volume and functional connectivity via structural and functional magnetic resonance imaging, respectively. Using the data from a recent meta-analysis of a genome-wide association study that comprised a large number of Chinese people, we calculated a polygenic risk score (PGRS) for each participant.
The imaging genetic analysis revealed that the individual PGRS showed a significantly negative correlation with the hippocampal grey matter volume and hippocampus–medial prefrontal cortex functional connectivity, both of which were lower in the people with schizophrenia than in the controls. We also found that the observed neuroimaging measures showed weak but similar changes in unaffected first-degree relatives of patients with schizophrenia.
These findings suggested that genetically influenced brain grey matter volume and functional connectivity may provide important clues for understanding the pathological mechanisms of schizophrenia and for the early diagnosis of schizophrenia.
We report the utility of whole-genome sequencing (WGS) conducted in a clinically relevant time frame (ie, sufficient for guiding management decision), in managing a Streptococcus pyogenes outbreak, and present a comparison of its performance with emm typing.
A 2,000-bed tertiary-care psychiatric hospital.
Active surveillance was conducted to identify new cases of S. pyogenes. WGS guided targeted epidemiological investigations, and infection control measures were implemented. Single-nucleotide polymorphism (SNP)–based genome phylogeny, emm typing, and multilocus sequence typing (MLST) were performed. We compared the ability of WGS and emm typing to correctly identify person-to-person transmission and to guide the management of the outbreak.
The study included 204 patients and 152 staff. We identified 35 patients and 2 staff members with S. pyogenes. WGS revealed polyclonal S. pyogenes infections with 3 genetically distinct phylogenetic clusters (C1–C3). Cluster C1 isolates were all emm type 4, sequence type 915 and had pairwise SNP differences of 0–5, which suggested recent person-to-person transmissions. Epidemiological investigation revealed that cluster C1 was mediated by dermal colonization and transmission of S. pyogenes in a male residential ward. Clusters C2 and C3 were genomically diverse, with pairwise SNP differences of 21–45 and 26–58, and emm 11 and mostly emm120, respectively. Clusters C2 and C3, which may have been considered person-to-person transmissions by emm typing, were shown by WGS to be unlikely by integrating pairwise SNP differences with epidemiology.
WGS had higher resolution than emm typing in identifying clusters with recent and ongoing person-to-person transmissions, which allowed implementation of targeted intervention to control the outbreak.
In this contribution, we have made use of the contemporary equation of states (EOSs) for the complete neutron star structure, and confronted them with one particular glitch constrain for the crustal moment of inertia (MOI). We find that with these EOSs, the radii of three millisecond pulsars selected by NICER: PSR J0437-4715, PSR J1614-2230, PSR J0751+1807, are all around 12.5 km. Also, a star with M ≲ 1.55M⊙ would fulfill the MOI calculation for glitch constrain with the latest neutron superfluidity density, and the glitch crisis might not be present.
Formation of a nanometer-scale oxide surface layer is common when a material is exposed to oxygen-containing environment. Employing aberration-corrected analytical transmission electron microscopy and using single crystal SnSe as an example, we show that for an alloy, a second thin amorphous layer can appear underneath the outmost oxide layer. This inner amorphous layer is not oxide based, but instead originates from solid-state amorphization of the base alloy when its free energy rises to above that of the metastable amorphous state; which is a result of the composition shift due to the preferential depletion of the oxidizing species, in our case, the outgoing Sn reacting with the oxygen atmosphere.
Fractures are important for shale-gas reservoirs with low matrix porosity because they increase the effective reservoir space and migration pathways for shale gas, thus favouring an increased volume of free gas and the adsorption of gases in shale reservoirs, and they increase the specific surface area of gas-bearing shales which improves the adsorption capacity. We discuss the characteristics and dominant factors of fracture development in a continental organic matter-rich shale reservoir bed in the Yanchang Formation based on observations and descriptions of fracture systems in outcrops, drilling cores, cast-thin sections and polished sections of black shale from the Upper Triassic Yanchang Formation in the SE Ordos Basin; detailed characteristics and parameters of fractures; analyses and tests of corresponding fracture segment samples; and the identification of fracture segments with normal logging. The results indicate that the mineral composition of the continental organic-matter-rich shale in the Yanchang Formation is clearly characterized by a low brittle mineral content and high clay mineral content relative to marine shale in the United States and China and Mesozoic continental shale in other basins. The total content of brittle minerals, such as quartz and feldspar, is c. 41%, with quartz and feldspar accounting for 22% and 19% respectively, and mainly occurring as plagioclase with small amounts of carbonate rocks. The total content of clay minerals is high at up to 52%, and mainly occurs as a mixed layer of illite-smectite (I/S) which accounts for more than 58% of the total clay mineral content. The Upper Triassic Yanchang Formation developed two groups of fracture (joint) systems: a NW–SE-trending system and near-E–W-trending system. Multiple types of fractures are observed, and they are mainly horizontal bedding seams and low-dip-angle structural fractures. Micro-fractures are primarily observed in or along organic matter bands. Shale fractures were mainly formed during Late Jurassic – late Early Cretaceous time under superimposed stress caused by regional WNW–ESE-trending horizontal compressive stress and deep burial effects. The extent of fracture development was mainly influenced by multiple factors (tectonic factors and non-tectonic factors) such as the lithology, rock mechanical properties, organic matter abundance and brittle mineral composition and content. Specifically, higher sand content has been observed to correspond to more rapid lithological changes and more extensive fracture development. In addition, higher organic matter content has been observed to correspond to greater fracture development, and higher quartz, feldspar and mixed-layer I/S contents have been observed to correspond to more extensive micro-fracture development. These results are consistent with the measured mechanical properties of the shale and silty shale, the observations of fractures in cores and thin-sections from more than 20 shale-gas drilling wells, and the registered anomalies from gas logging.
To investigate the presence of neuropsychiatric symptoms (NPS) and sub-syndromes in elderly community-dwelling Asians with varying severity of cognitive impairment.
Chinese and Malay participants (n = 613) from the Epidemiology of Dementia in Singapore (EDIS) Study aged ≥ 60 years underwent clinical examination, neuropsychological testing, and NPS assessment using the Neuropsychiatric Inventory (NPI). Diagnosis of no cognitive impairment (NCI), cognitive impairment-no dementia (CIND), including CIND-mild and CIND-moderate, and dementia were made using established criteria.
A significant increase in the numbers of NPS was observed accompanying with increasing severity of cognitive impairment (p < 0.001). Compared to those with NCI/CIND-mild, participants with CIND-moderate [Odds ratio (OR): 4.2, 95% confidence interval (CI): 1.8–10.0] or dementia [OR: 9.2, 95% CI: 2.3–36.0] were more likely to have two or more neuropsychiatric sub-syndromes. Participants with CIND-moderate were more likely to have hyperactivity [OR: 2.0, 95% CI: 1.0–3.8] and apathy [OR: 2.9, 95% CI: 1.0–8.4] sub-syndromes, whereas patients with dementia were more likely to have psychosis [OR: 6.9, 95% CI: 2.4–20.1], affective (OR: 8.7, 95% CI: 1.8–42.9), and hyperactivity (OR: 5.4, 95% CI: 1.8–16.1). Furthermore, executive dysfunction and visual memory impairment were associated with the presence of three neuropsychiatric sub-syndromes; whist language and visuomotor speed impairment were related to the presence of two sub-syndromes. By contrast, impairment in attention, verbal memory, and visuoconstruction were not associated with any of the sub-syndromes.
The presence of NPS and sub-syndromes increase with increasing severities of cognitive impairment, and different neuropsychiatric syndromes are associated with specific impairment on cognitive domains in community-dwelling Asian elderly.
Elevated bonding temperature for interconnection deteriorates the reliability of both the device and the interconnect; hence the imperative for developing low temperature bonding methods. This study investigates the feasibility of using self-assembled monolayers (SAMs) to assist direct gold-gold bonding. This involves a simple molecular self-assembly process whereby a monolayer of alkyl chains with a sulfur end group is attached to the gold surface prior to thermocompression bonding. Using this method, we have achieved gold to gold bonding at a bonding temperature below 100°C, a significant reduction compared to the conventional bonding temperatures of above 150 °C. We attribute this temperature reduction to two properties of SAMs - (1) surface passivation of the Au surface that precludes adsorption of surface contaminants, and (2) The easy displacement of SAMs through thermal desorption just before bonding occurs. This SAMs-assisted bonding mechanism is supported by X-ray photoelectron spectroscopy (XPS) and surface plasmon resonance (SPR) results.
A study on the comparison of porous TiO2-SiO2 mixed oxides synthesized variously via the “amine directed” method is reported. The amine capping groups were octylamine, dodecylamine, octyldecylamine, aniline, and isobutylamine. The mixed oxide is characterized by x-ray diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM), infrared spectroscopy (IR), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC) and Brunauer-Emmett-Teller analysis (BET). While XRD, SEM and TEM provide mainly (bulk) structural information on the mixed oxide preparations, BET (N2 physisorption) probes into their surface area and texture. IR evidence suggests that intimate chemical mixing of both oxides has occurred, while BET measurements show that high surface areas are attainable and that the mixed oxide is more thermally stable than pure (control) samples of TiO2.
In this paper, the material and electrical characteristics of Nickel-Silicon-Carbon (NiSi:C) films were investigated for the first time to ascertain the compatibility of NiSi:C contacts to silicon-carbon (Si:C) source/drain stressors. The incorporation of 1 atomic percent of carbon was found to increase both the Ni2Si-to-NiSi and NiSi-to-NiSi2 transformation temperatures. Our results show that the incorporation of carbon stabilizes the interfacial and surface morphology of NiSi:C films. We speculate that the incorporated carbon segregates into the NiSi:C grain boundaries and suppresses film agglomeration and NiSi-to-NiSi2 phase transformation. X-ray diffraction analysis further revealed that the formed NiSi:C films possessed a preferred orientation. Current-voltage measurements for NiSi and NiSi:C n+/p junctions exhibit similar cumulative distribution for junction leakage indicating that carbon incorporation does not have a detrimental impact on the n+/p junction integrity. Our results suggest that NiSi:C is a suitable self-aligned contact metal silicide to n-channel MOSFETs with SiC S/D stressors in a similar manner to the way in which NiSiGe is used for p-channel MOSFETs with SiGe S/D stressors.
Variations in fish communities of shallow lakes in the Yangtze basins were investigated from September 2007 to September 2009. Six lakes were chosen for comparative study of species composition and diversity in relation to environmental variations. Lake heterogeneity was described with environmental physico-chemical variables, using principal component analysis. Sixteen families, composed of 75 species of fish were found in the studied lakes, Cyprinidae being the dominant group. Fish species were divided by habitat preference and trophic guild: benthopelagic and herbivorous fish were the most common guilds in all lakes. Species diversity and richness were significantly higher in spring, while the evenness, expressed by equitability of Simpson’s index, was not significantly different among seasons. Species richness and diversity were significantly higher in vegetated lakes (e.g. Liangzihu Lake) than in non-vegetated lakes (e.g. Biandantang Lake), with the largest area (Liangzihu Lake) harbouring the largest species richness and the greatest diversity. The relationship between environmental variables and fish assemblage were analysed using canonical correspondence analysis (CCA). The dominant gradients describing species composition and abundance among the sampling sites were: total phosphorus, total nitrogen, chlorophyll a, transparency and water depth. Our study led to the following conclusions: 1) the water quality was better - i.e. high transparency, low total phosphorus (TP) and total nitrogen (TN) and chlorophyll a- in vegetated lakes than in unvegetated lakes; 2) vegetated lakes had higher fish diversity than unvegetated lakes; 3) fish relative abundance (CPUE: number of fish per fishing pass) was significantly related to water chemical parameters. Consequently, the details of the findings are useful and relevant for developing suitable conservation strategies to sustain the integrity of fish communities in these lakes.
Recent studies suggest that the underperformance of IPOs in the post-1970 sample may be a small sample effect or “Peso problem.” That is, IPO underperformance may result from observing too few star performers ex post than were expected ex ante. We develop a model of IPO performance that captures this intuition by allowing returns to be drawn from mixtures of outstanding, benchmark, or poor performing states. We estimate the model under the null of no ex ante average IPO underperformance and construct small sample distributions of various statistics measuring IPO relative performance. We find that small sample biases are extremely unlikely to account for the magnitude of the post-1970 IPO underperformance observed in data.
This study describes the current status of the small
fish community in Niushan Lake in China, and examines the spatial and
seasonal variations of the community in relation to key environmental
factors. Based on macrophyte cover conditions, the lake was divided into
three major habitat types: (1) Potamogeton maackianus habitat, (2) Potamogeton maackianus and Myriophyllum spicatum habitat, and (3)
uncovered or less-covered habitat. Fish were sampled quantitatively in the
three habitat types by block nets seasonally from September 2002 to August
2003. A total of 10 469 individuals from 27 fish species were caught, among
which 20 species were considered as small fishes. Rhodeus ocellatus, Paracheilognathus imberbis, Pseudorasbora parva, Micropercops swinhonis and Cultrichthys erythropterus were recognized
as dominant small fishes according to their abundance and occurrence. It was
noted that (1) small fishes predominated the total number of fish species in
the lake, which reflected to some degree the size diminution phenomenon of
fish resources; (2) many small fishes had plant detritus as their food item,
which was consistent with the abundance of macrophyte detritus in the lake
and implied the importance of detritus in supporting small fish secondary
production. Canonical correspondence analysis suggested that the spatial
distributions of most small fishes were associated with complex macrophyte
cover conditions. Macrophyte biomass was positively correlated with species
richness, diversity index and the catch per unit of effort (CPUE) of the fish community. Water depth had no
significant effects on species diversity and distribution of the small
fishes. Correspondence analysis revealed a higher occurrence of the small
fishes and higher abundance of individuals in summer and autumn. Seasonal
length-frequency distributions of several species indicated that more larval
and juvenile individuals appeared in spring and summer. This study provides
some baseline information which will be essential to long-term monitoring of
small fish communities in the Yangtze lakes.
The pH of the solution in contact with a hydrous zirconium oxide plays a dominant role in determining the crystal phase, tetragonal or monoclinic, in the calcined material. The substitution of low concentrations of hafnium for zirconium destabilizes the tetragonal phase so that only the monoclinic phase is formed; the amount of Hf required for destabilization depends upon the pH used for the preparation of the hydrous oxide. While this study has defined a phenomenon, the results do not permit a definition of the mechanism for it.
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