The fatigue behavior of intermetallic compounds is reviewed. The effects of long range order, stoichiometry, test temperature and test environment on crack initiations high cycle fatigue lives and crack growth rates are emphasized. In the case of Ni3Al+B stoichiometry affects high cycle lives largely through the influence of aluminum on ductility and notch sensitivity. High cycle fatigue behavior of Fe3Al is dependent upon stoichiometry and temperature in a complex way which is connected with the formation of superlattice dislocations and with phase changes during high temperature exposure. Oxygen and hydrogen are shown to be detrimental to high cycle fatigue and crack growth in several compounds.