The study of corrosion behavior of polyurethane/nanohydroxyapatite hybrid coating in aerated Hank solution at 25 °C by Potentiodinamic and Electrochemical Impedance techniques was realized. The nanohydroxyapatite (nHA) powders were synthesized by ultrasonic assisted co-precipitation wet chemical method and then mixed with pure polyurethane (PU) during the polymerization. Results were supported by SEM morphologic characterization. Results showed that good corrosion resistance of hybrid coating, showing small corrosion product layer formation. Corrosion mechanisms are affected by an increasing of polarization resistance, promoting decreasing in the corrosion rates. Diffusion of ionic species was the governing mechanism in the corrosion behavior of polyurethane/nanohydroxyapatite hybrid coating.