Ganoderma lucidum (a mushroom used in traditional Chinese medicine) compounds may attenuate ageing-related physiological changes and restore normal immunity. However, studies on the physiological effects of Ganoderma lucidum dry extract food supplements are few. Therefore, here, we aimed to investigate the effects of Ganoderma lucidum dry extract food supplement on the lymphocyte function of older women. This was a double-blind clinical trial (n 60) with a final 39 older volunteers, divided into two groups Ganoderma lucidum (n 23) and placebo (n 16). The Ganoderma lucidum group received 2000 mg/d of Ganoderma lucidum dry extract for 8 weeks. We used flow cytometry to determine the lymphocyte profile. CD4+ lymphocyte gene expression was evaluated by real-time polymerase chain reaction. We observed that in the Ganoderma lucidum group, concanavalin A stimulation increased lymphocyte proliferation. Further, we observed an increase in expression of Forkhead box P3, transforming growth factor-beta, IL-10, IL-6, retinoic acid receptor-related orphan receptor gamma, GATA-binding protein 3 and interferon gamma genes in the Ganoderma lucidum group. Furthermore, in the Ganoderma lucidum group, ionomycin and phorbol 12-myristate 13-acetate stimulation led to decrease in Th17+ cells and increase in Th2+ cells. Thus, in older women, Ganoderma lucidum regulates T lymphocyte function leading to a predominant anti-inflammatory action but does not induce T lymphocyte proliferation through CD28 signalling pathway.

It is well known that X-ray luminosity (Lx) originating from high mass X-ray binaries (HMXBs) is tightly correlated with the host galaxy’s star formation rate (SFR). We explore this connection using a sample representative of the star-formation activity in the local Universe (Star-Formation Reference Survey; SFRS) along with a comprehensive set of star-formation (radio, FIR, 24μm, 8 μm, Hα, UV, SED fitting) and stellar mass (K-band, 3.6 μm, SED fitting) indicators, and Chandra observations. We investigate the Lx–SFR and Lx– stellar mass (M*) scaling relations down to sub-galactic scales of ∼lkpc2. This way we extend these relations to extremely low SFR (∼10−6M⊙.yr−1) and M* (∼104M⊙). We also quantify their scatter and their dependence on the age of the local stellar populations as inferred from the different age sensitive SFR indicators. These results are particularly important for setting the benchmark for the formation of X-ray binaries in vigorous, but low SFR objects such as galaxies in the early Universe.

Nearby star-forming galaxies offer a unique environment to study the populations of young (<100 Myr) accreting binaries. These systems are tracers of past populations of massive stars that heavily affect their immediate environment and parent galaxies. Using a Chandra X-ray Visionary program, we investigate the young neutron-star binary population in the low metallicity of the Small Magellanic Cloud (SMC) by reaching quiescent X-ray luminosity levels (~few times 1032 erg/s). We present the first measurement of the formation efficiency of high-mass X-ray binaries (HMXBs) as a function of the age of their parent stellar populations by using 3 indicators: the number ratio of HMXBs to OB stars, to the SFR, and to the stellar mass produced during the specific star-formation burst they are associated with. In all cases, we find that the HMXB formation efficiency increases as a function of time up to ~40–60 Myr, and then gradually decreases.

Almost all confirmed optical counterparts of HMXBs in the SMC are OB stars with equatorial decretion disks (OBe). These sources emit strongly in Balmer lines and standout when imaged through narrow-band Hα imaging. The lack of secure counterparts for a significant fraction of the HMXBs motivated us to search for more. Using the catalogs for OB/OBe stars (Maravelias et al.2017) and for HMXBs (Haberl & Sturm 2016) we detect 70 optical counterparts (out of 104 covered by our survey). We provide the first identification of the optical counterpart to the source XTEJ0050-731. We verify that 17 previously uncertain optical counterparts are indeed the proper matches. Regarding 52 confirmed HMXBs (known optical counterparts with Hα emission), we detect 39 as OBe and another 13 as OB stars. This allows a direct estimation of the fraction of active OBe stars in HMXBs that show Hα emission at a given epoch to be at least ∼75% of their total HMXB population.

. The nature and evolution of ultraluminous X-ray sources (ULXs) is an open problem in astrophysics. They challenge our current understanding of stellar compact objects and accretion physics. The recent discovery of pulsar ULXs further demonstrates the importance of this intriguing and rare class of objects.

In order to overcome the difficulties of directly studying the optical associations of ULXs, we generally resort in statistical studies of the stellar properties of their host galaxies. We present the largest such study based on the combination of Chandra archival data with the most complete galaxy catalog of the Local Universe. Incorporating robust distances and stellar population parameters based on associated multi-wavelength information, and we explore the association of ULXs with galaxies in the (star formation rate, stellar mass, metallicity) space.

We confirm the known correlation with morphology, star formation rate and stellar mass, while we find an excess of ULXs in dwarf galaxies, indicating dependence on age and metallicity.

We use deep Chandra and HST data to uniquely classify the X-ray binary (XRB) populations in M81 on the basis of their donor stars and local stellar populations (into early-type main sequence, yellow giant, supergiant, low-mass, and globular cluster). First, we find that more massive, redder, and denser globular clusters are more likely to be associated with XRBs. Second, we find that the high-mass XRBs (HMXBs) overall have a steeper X-ray luminosity function (XLF) than the canonical star-forming galaxy XLF, though there is some evidence of variations in the slopes of the sub-populations. On the other hand, the XLF of the prototypical starburst M82 is described by the canonical powerlaw (αcum ∼ 0.6) down to LX ∼ 1036 erg s−1. We attribute variations in XLF slopes to different mass transfer modes (Roche-lobe overflow versus wind-fed systems).

We analyse the vertical distribution of High Mass X-ray Binaries (HMXBs) in NGC 55, the nearest edge-on galaxy to the Milky Way. Our analysis reveals significant spatial offsets of HMXBs from the star forming regions, greater than those observed in the SMC and the LMC but similar with the Milky Way. The spatial offsets can be explained by a momentum kick the X-ray binaries receive during the formation of the compact object. The difference between the scale height of the vertical distribution of HMXBs and the vertical distribution of star-forming activity is 0.48±0.04 kpc. The centre-of-mass velocity of the distribution of HMXBs in NGC 55 is moving at a velocity of 52.4±11.4 km s−1, greater than the corresponding velocity of HMXBs in the SMC and LMC, but consistent with velocities of Milky Way HMXBs.

The Small Magellanic Cloud (SMC) presents us with a unique opportunity to study in detail the effect of environmental processes (interaction with the LMC and the Milky Way) on its star formation history. With the 6.5m Magellan Telescope at the Las Campanas Observatory in Chile we have acquired deep B and I images in four 0.44 degree fields covering a large part of the main body of the SMC, yielding accurate photometry for 1,068,893 stars down to ~24th magnitude, with a spatial resolution of 0.201 arcsec/pixel. Colour-magnitude diagrams and luminosity functions (corrected for completeness) have been constructed, yielding significant new results that indicate at least two discrete star formation events around 2.7 and 4-5 Gyr ago.

SN 1987A has been observed with the Chandra X-ray Observatory over the entire course of the mission. We have re-analyzed the archival data by constructing an empirical point spread function and reconstructing high-resolution images using a Bayesian multi-scale image reconstruction algorithm. We are able to resolve structure in the equatorial ring of SN 1987A with unprecedented detail, at scales of $\approx \frac{1}{4}$ arcsec. We describe how the point spread function is constructed, and the reconstruction method, and explore the evolution of the inner ring at different epochs and passbands.